DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FeCH and fech

DIOPT Version :9

Sequence 1:	NP_524613.1	Gene:	FeCH / 43757	FlyBaseID:	FBgn0266268	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_571706.1	Gene:	fech / 58215	ZFINID:	ZDB-GENE-000928-1	Length:	409	Species:	Danio rerio

Alignment Length:	354	Identity:	203/354 - (57%)
Similarity:	269/354 - (75%)	Gaps:	0/354 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 QKPKTAILMLNMGGPTHTDQVHDYLLRIMTDRDMIQLPVQSRLGPWIAQRRTPEVQKKYKEIGGG 89
            :||||.|||||||||...:.|||:|||:..|.|.:|||||::|||:||:||||::|::|.:||||
Zfish    51 RKPKTGILMLNMGGPEKLEDVHDFLLRLFMDTDFMQLPVQNKLGPFIAKRRTPKIQEQYSKIGGG 115

  Fly    90 SPILKWTELQGQLMCEQLDRISPETAPHKHYVGFRYVNPLTENTLAEIEKDKPERVVLFSQYPQY 154
            |||..||.:||:.|.:.||.:.|:|||||.|:|||||:||||..:..:|||..||.|.|:|||||
Zfish   116 SPIKAWTTMQGEGMVKLLDEMCPDTAPHKFYIGFRYVHPLTEEAIELMEKDGVERAVAFTQYPQY 180

  Fly   155 SCATSGSSFNSIFTHYRSNNLPSDIKWSIIDRWGTHPLLIKTFAQRIRDELAKFVETKRNDVVIL 219
            ||:|:|||.|:|:.:|.:......::||:||||.||||||:.||:.:|:||.||...||:|||||
Zfish   181 SCSTTGSSLNAIYRYYSNRADRPKMRWSVIDRWPTHPLLIECFAEHVRNELDKFPVEKRDDVVIL 245

  Fly   220 FTAHSLPLKAVNRGDAYPSEIGASVHMVMQELGQTNPYSLAWQSKVGPLPWLAPATDDAIKGYVK 284
            |:||||||..|||||.||.|:||:|..||..||..|||.|.|||||||:.||.|.||:.|||..:
Zfish   246 FSAHSLPLSVVNRGDPYPQEVGATVQRVMDRLGHCNPYRLVWQSKVGPMAWLGPQTDEVIKGLCQ 310

  Fly   285 QGLKNFILVPIAFVNEHIETLHELDIEYCDELAKEVGVEEIRRAATPNDHPLFIDALTNVVADHL 349
            :|.:|.:||||||.::||||||||||||...|.:|||||.||||.:.|.:|||..||.::|..||
Zfish   311 RGKRNLLLVPIAFTSDHIETLHELDIEYSQVLGEEVGVENIRRAESLNGNPLFFRALADLVQSHL 375

  Fly   350 KSQQAVNPKFLMRCPMCSNPKCRESKSWY 378
            :|.::.:.:..:|||:|.||.|.::|:::
Zfish   376 QSNESCSRQLTLRCPLCVNPTCAQTKAFF 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FeCH	NP_524613.1	Ferrochelatase	29..349	CDD:279146	189/319 (59%)
		Ferrochelatase_N	29..190	CDD:239504	91/160 (57%)
		Ferrochelatase_C	195..332	CDD:238240	85/136 (63%)
fech	NP_571706.1	Ferrochelatase	55..375	CDD:279146	189/319 (59%)
		Ferrochelatase_N	55..216	CDD:239504	91/160 (57%)
		Ferrochelatase_C	221..358	CDD:238240	85/136 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577511
Domainoid	1	1.000	408	1.000	Domainoid score	I665
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H113
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1621
OMA	1	1.010	-	-		QHG62486
OrthoDB	1	1.010	-	-		D1003638at2759
OrthoFinder	1	1.000	-	-		FOG0004364
OrthoInspector	1	1.000	-	-		oto38769
orthoMCL	1	0.900	-	-		OOG6_101310
Panther	1	1.100	-	-	LDO	PTHR11108
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R558
SonicParanoid	1	1.000	-	-		X3086
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.900