DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FeCH and Fech

DIOPT Version :9

Sequence 1:	NP_524613.1	Gene:	FeCH / 43757	FlyBaseID:	FBgn0266268	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_032024.2	Gene:	Fech / 14151	MGIID:	95513	Length:	422	Species:	Mus musculus

Alignment Length:	354	Identity:	199/354 - (56%)
Similarity:	266/354 - (75%)	Gaps:	0/354 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 QKPKTAILMLNMGGPTHTDQVHDYLLRIMTDRDMIQLPVQSRLGPWIAQRRTPEVQKKYKEIGGG 89
            :||||.|||||||||....:|.|:|.|:..|||::.||:|::|.|:||:||||::|::|:.||||
Mouse    64 RKPKTGILMLNMGGPETLGEVQDFLQRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGG 128

  Fly    90 SPILKWTELQGQLMCEQLDRISPETAPHKHYVGFRYVNPLTENTLAEIEKDKPERVVLFSQYPQY 154
            |||..||..||:.|.:.||.:||.|||||:|:|||||:||||..:.|:|:|..||.:.|:|||||
Mouse   129 SPIKMWTSKQGEGMVKLLDELSPATAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQY 193

  Fly   155 SCATSGSSFNSIFTHYRSNNLPSDIKWSIIDRWGTHPLLIKTFAQRIRDELAKFVETKRNDVVIL 219
            ||:|:|||.|:|:.:|........:|||.||||.||||||:.||..|..||..|.|.||::||||
Mouse   194 SCSTTGSSLNAIYRYYNEVGQKPTMKWSTIDRWPTHPLLIQCFADHILKELNHFPEEKRSEVVIL 258

  Fly   220 FTAHSLPLKAVNRGDAYPSEIGASVHMVMQELGQTNPYSLAWQSKVGPLPWLAPATDDAIKGYVK 284
            |:|||||:..|||||.||.|:||:||.||::||..|||.|.|||||||:|||.|.||:||||..:
Mouse   259 FSAHSLPMSVVNRGDPYPQEVGATVHKVMEKLGYPNPYRLVWQSKVGPVPWLGPQTDEAIKGLCE 323

  Fly   285 QGLKNFILVPIAFVNEHIETLHELDIEYCDELAKEVGVEEIRRAATPNDHPLFIDALTNVVADHL 349
            :|.||.:||||||.::|||||:||||||...||::.|.|.||||.:.|.:|||..||.::|..|:
Mouse   324 RGRKNILLVPIAFTSDHIETLYELDIEYSQVLAQKCGAENIRRAESLNGNPLFSKALADLVHSHI 388

  Fly   350 KSQQAVNPKFLMRCPMCSNPKCRESKSWY 378
            :|.:..:.:..:.||:|.||.||::||::
Mouse   389 QSNKLCSTQLSLNCPLCVNPVCRKTKSFF 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FeCH	NP_524613.1	Ferrochelatase	29..349	CDD:279146	185/319 (58%)
		Ferrochelatase_N	29..190	CDD:239504	88/160 (55%)
		Ferrochelatase_C	195..332	CDD:238240	84/136 (62%)
Fech	NP_032024.2	Ferrochelatase	68..388	CDD:279146	185/319 (58%)
		Ferrochelatase_N	68..229	CDD:239504	88/160 (55%)
		Ferrochelatase_C	234..371	CDD:238240	84/136 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834541
Domainoid	1	1.000	391	1.000	Domainoid score	I776
eggNOG	1	0.900	-	-		E1_COG0276
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H113
Inparanoid	1	1.050	425	1.000	Inparanoid score	I1746
Isobase	1	0.950	-	0	Normalized mean entropy	S957
OMA	1	1.010	-	-		QHG62486
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004364
OrthoInspector	1	1.000	-	-		oto93433
orthoMCL	1	0.900	-	-		OOG6_101310
Panther	1	1.100	-	-	LDO	PTHR11108
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R558
SonicParanoid	1	1.000	-	-		X3086
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740