DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rift and SLC52A2

DIOPT Version :9

Sequence 1:	NP_651901.3	Gene:	Rift / 43756	FlyBaseID:	FBgn0039882	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001240744.1	Gene:	SLC52A2 / 79581	HGNCID:	30224	Length:	445	Species:	Homo sapiens

Alignment Length:	429	Identity:	156/429 - (36%)
Similarity:	229/429 - (53%)	Gaps:	41/429 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 RSWLVDVLAIFFGIGTWLGVNGTFIQLPLLVDEAPEGWSLPSYLSVMVQIGNLGPLLYTAIQKYS 136
            |..|..:|...||:|:|..|||.:::||::|.|.|||||||||:||:|.:||||.|:.|..::.:
Human     8 RPVLTHLLVALFGMGSWAAVNGIWVELPVVVKELPEGWSLPSYVSVLVALGNLGLLVVTLWRRLA 72

  Fly   137 PKKLNDGWTIHGVLLVGAISCLLTAFFYNQTASVAGTDHSLALFLLTCFTALNACTSSVLFMPYM 201
            |.| ::...|..|.::|.:...|.|..::..|.|||..||:|...|....||..|.|:|.|:|::
Human    73 PGK-DEQVPIRVVQVLGMVGTALLASLWHHVAPVAGQLHSVAFLALAFVLALACCASNVTFLPFL 136

  Fly   202 GRFKEQYMVTYFIGEGLSGLLPSVTALIQGIGESGDC--VLVNVTESGEEVYALRKTPP-----R 259
            .....:::.::|:|:|||.|||.|.||:||:|.. :|  ..:|.|..          ||     |
Human   137 SHLPPRFLRSFFLGQGLSALLPCVLALVQGVGRL-ECPPAPINGTPG----------PPLDFLER 190

  Fly   260 FDTRVFFLILFALMV---LAYVGYALL----NSLPL-------------ARREYAQVT-VSEGNK 303
            |....||..|.||:|   .|:.|..||    .|:|.             |..|..:.: :.|...
Human   191 FPASTFFWALTALLVASAAAFQGLLLLLPPPPSVPTGELGSGLQVGAPGAEEEVEESSPLQEPPS 255

  Fly   304 YVYGEADN-QPKAEKLSKGQYTYLLLLIGAISLFSNGMFGSIQSYSSAPYGSQAYHLAATLSVIA 367
            ...|.... .|||.:|...:...||.|:.|.:..:||:..::||:|..|||..|||||..|...|
Human   256 QAAGTTPGPDPKAYQLLSARSACLLGLLAATNALTNGVLPAVQSFSCLPYGRLAYHLAVVLGSAA 320

  Fly   368 NPVACFMAMFLHFTSLRIITVLSILAGLLTSYVFTTAALSPLPPLHDQTVGAVLVVTAWTLLVGI 432
            ||:|||:||.:...||..:..||:|......|:...|.|||.|||...:.|.||||.:|.|.:|:
Human   321 NPLACFLAMGVLCRSLAGLGGLSLLGVFCGGYLMALAVLSPCPPLVGTSAGVVLVVLSWVLCLGV 385

  Fly   433 VSYTKLGITTVMRAQGGQSLVWVGAITQLGSAIGAVAIF 471
            .||.|:..::::...|..:|:..|...|:||.:||||:|
Human   386 FSYVKVAASSLLHGGGRPALLAAGVAIQVGSLLGAVAMF 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rift	NP_651901.3	DUF1011	320..418	CDD:283816	39/97 (40%)
SLC52A2	NP_001240744.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..264		4/35 (11%)
SLC52A2	NP_001240744.1	DUF1011	273..371	CDD:310675	39/97 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148948
Domainoid	1	1.000	79	1.000	Domainoid score	I8664
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52392
OrthoDB	1	1.010	-	-		D356719at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12929
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3974
SonicParanoid	1	1.000	-	-		X1135
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.950