DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42233 and DCAF5

DIOPT Version :9

Sequence 1:	NP_651899.2	Gene:	CG42233 / 43754	FlyBaseID:	FBgn0250755	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	XP_006720360.1	Gene:	DCAF5 / 8816	HGNCID:	20224	Length:	977	Species:	Homo sapiens

Alignment Length:	972	Identity:	278/972 - (28%)
Similarity:	421/972 - (43%)	Gaps:	283/972 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RKMSLWRNLRS----LETRNL--DVALSQRENILVAGHLPSAIFRERLSAAQNLYQRNLTGHYGC 98
            |:..|..::||    |..|.|  |..|:|            ...|.||...:|||:::|.||:||
Human     3 RRAGLGGSMRSVVGFLSQRGLHGDPLLTQ------------DFQRRRLRGCRNLYKKDLLGHFGC 55

  Fly    99 VNALEFS-SGGQFLASGGDDKRVLLWNIDRELVSKLGKPRSMNEKHASNIFCLGFDTQNSYIFSG 162
            |||:||| :|||:|.|||||:|||||::::.:.|:: ||..:..:|.||||||.|::.|:.:|||
Human    56 VNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRV-KPIQLKGEHHSNIFCLAFNSGNTKVFSG 119

  Fly   163 GNDDLVIQHDLETGKILNHFSHDGPVYGLSVDRISGHLLSVATEHGEILVYDLR-AGKSEPLAIA 226
            |||:.||.||:|:.:.|:.|:|:..||||||..::.::.:.:::.|.:|::|:| :...||..:|
Human   120 GNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPFCLA 184

  Fly   227 KFKTPFNAVEFHPLNGNFLATANAKRGAMLWDLRHHQQALCQYNYIPESPSCMSVRFNCNGTLLL 291
            .:.:.|::|.|:|:....|||||:|.|..|||:|..|.:|.:|.......|.||||||.|||.||
Human   185 NYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLL 249

  Fly   292 TLHRRLPPILYSPGAPEPVATFYHDEYFNSCTMKSCTFAGPQDE--------------------- 335
            .|.|||||:||...:..||..|.:..||||||||||.|||.:|:
Human   250 ALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQKPEAEGKVIFFRLCLATKPIF 314

  Fly   336 --------------LVVSGSDNFNMFIWRLE------GVDLDEKNQWMETTPVILAGHRSIVNQV 380
                          .::||||:||:::||:.      |:.......:|     :|.|||||||||
Human   315 MDLRRPRTKTSSQHYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFM-----VLKGHRSIVNQV 374

  Fly   381 RYNRERCLLASSGVEKIIKLWSPFAQQGWEGSL------------TQAEALPYCTRALYRESSDH 433
            |:|....::.|||||||||:|||:.|.|..|.|            |..|.:     :|...|...
Human   375 RFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEEYI-----SLVLNSGSG 434

  Fly   434 VSQDFSARSTDEDQVMLAFFDTLVQHELESWSTVDNQNSSKS------------STHTSTCSEAS 486
            :|.|::.:|..||..|:||||:||:.|:|.||:..:.:.|:|            |.:|.:.|.||
Human   435 LSHDYANQSVQEDPRMMAFFDSLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSAS 499

  Fly   487 SPTEEPS--DE----------------------------ED--------------QDPQ----TD 503
            .|...|.  ||                            ||              ||.:    ::
Human   500 LPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPTCEDAASRQQRLSALRRYQDKRLLALSN 564

  Fly   504 RNQNEENVQDQDIDT--------PNVSELSWQTYPNRIFYLIAKKRRSLLQLAVRGTSRHPRNVD 560
            .:.:||||.:.::||        |:..:.|..:..       :.......:|..|..|...||..
Human   565 ESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSS-------SSSSEDEEELNERRASTWQRNAM 622

  Fly   561 QLLQRLIGEQKQAATQARISDWLEETQRLFGDDEL-------------PTTSAEAAAREQRRRDG 612
            :..|:...|.|.:|.       ::.|....|:|..             ||:|.|       |...
Human   623 RRRQKTTREDKPSAP-------IKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPE-------RSTS 673

  Fly   613 VLLCRNRRTQEFKIVETPKSRITQRTRKRKLRQLIQTTKHRRAT---------GRPRTTEMDEGS 668
            .|..:..|......:|:.:.:|.:..:..:...:..:......|         ||..|:..|..:
Human   674 TLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKDNPA 738

  Fly   669 ASSD------------------TGASYDSDEEET----SSGDNNNNNSN------ERESVRTDDD 705
            .||.                  .|.|.|:.:|||    |:|..:.::|:      |..|..|.:.
Human   739 PSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNS 803

  Fly   706 GD----------NSSTTSLTSMEAQFSQAPSTSSSFL----------------FHQLE----SNN 740
            |.          |....|..:.|......|..|.|.|                ...||    ::|
Human   804 GSVEHPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHN 868

  Fly   741 NSQ--------HTSNQN--------------------HKALNG--LIPDNCNTESTASTSSS 772
            |.:        |.:.||                    :.:|.|  |..|.|.:|....|.::
Human   869 NGRLHPRPPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSLTGTLLHKDCCGSEMACETPNA 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42233	NP_651899.2	WD40	<45..404	CDD:225201	166/407 (41%)
		WD40 repeat	56..91	CDD:293791	10/36 (28%)
		WD40	90..402	CDD:295369	150/354 (42%)
		WD40 repeat	100..142	CDD:293791	22/42 (52%)
		WD40 repeat	147..183	CDD:293791	18/35 (51%)
		WD40 repeat	191..225	CDD:293791	9/34 (26%)
		WD40 repeat	232..270	CDD:293791	17/37 (46%)
		WD40 repeat	278..371	CDD:293791	46/133 (35%)
		WD40 repeat	377..401	CDD:293791	15/23 (65%)
DCAF5	XP_006720360.1	WD40	16..>396	CDD:225201	162/397 (41%)
		WD40	49..396	CDD:295369	150/352 (43%)
		WD40 repeat	57..98	CDD:293791	22/41 (54%)
		WD40 repeat	104..139	CDD:293791	18/34 (53%)
		WD40 repeat	146..187	CDD:293791	12/40 (30%)
		WD40 repeat	191..228	CDD:293791	16/36 (44%)
		WD40 repeat	280..358	CDD:293791	19/77 (25%)
		WD40 repeat	371..395	CDD:293791	15/23 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146519
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4227
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008129
OrthoInspector	1	1.000	-	-		oto89952
orthoMCL	1	0.900	-	-		OOG6_107257
Panther	1	1.100	-	-	LDO	PTHR15574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3879
SonicParanoid	1	1.000	-	-		X6083
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.730