DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42233 and wdtc1

DIOPT Version :9

Sequence 1:	NP_651899.2	Gene:	CG42233 / 43754	FlyBaseID:	FBgn0250755	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001124078.1	Gene:	wdtc1 / 570606	ZFINID:	ZDB-GENE-030131-3224	Length:	674	Species:	Danio rerio

Alignment Length:	718	Identity:	145/718 - (20%)
Similarity:	209/718 - (29%)	Gaps:	335/718 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LWRNLRSLETRNLDVALSQRENILVAGHLPSAIFRERLSAAQNLYQRNLTGHYGCVNALEFSSGG 108
            |.|.:|  |.|.||.   ||..     |:... |.:||.     .:..|.||.||||.||::..|
Zfish    17 LHRQIR--ENRALDF---QRHY-----HVTDP-FIKRLG-----LEAELQGHSGCVNCLEWNEKG 65

  Fly   109 QFLASGGDDKRVLLWNIDRELVSKLGKPRSMNEKHASNIFCLGF--DTQNSYIFSGGNDDLVIQH 171
            ..||||.||:..::|:..|.  |||   .:|:..||:|||.:.|  .:.:..:.:|..|..|..|
Zfish    66 DLLASGSDDQHAIIWDPFRH--SKL---ITMHTGHAANIFSVKFLPHSDDRILITGAADTKVHVH 125

  Fly   172 DLETGKILNHFS-HDGPVYGLSVDRISGHLLSVATEHGEILVYDLR-AGKSEPLAIAKFKTPFNA 234
            |:...:.::.|| |...|..::...:..:....|.|.|.|..|||| :.|...:.|...:.....
Zfish   126 DVTAKETIHMFSDHTNRVKRIATAPMWPNTFWSAAEDGLIRQYDLRESSKRSDVLIDLTEYCGQL 190

  Fly   235 VE-----FHPLNGNFLATANAKRGAMLWDLR---HHQQALCQ----------------------- 268
            ||     .:|.:.|:||.........|:|:|   :|:::|.|
Zfish   191 VEAKCLAVNPRDNNYLAVGANGPFVRLYDIRMIHNHRKSLSQSSSAGVHTFCDKRKSIPDGAGQY 255

  Fly   269 ------------YN---------YIPESPSCMSVRFNCNGTLL----LTLHRR------------ 296
                        ||         |:..||....:..|..|..:    ||..:|
Zfish   256 YVAGHLPVKLPDYNNRLRVLVATYVTFSPDGTELLVNMGGEQVYLFDLTFKQRPYTFLLPKKCHS 320

  Fly   297 ------------------LP-----------------PI-----------------------LYS 303
                              ||                 |:                       |||
Zfish   321 STDVQNGKTTNGVSNGIHLPASRLKLAKVSSSGSGDLPLHLERIKQRANDAFARQQWTQAIQLYS 385

  Fly   304 PGAPE--PVATFY---------------------------------------------------- 314
            .|..|  |.|..|
Zfish   386 LGIHEAGPNAMLYGNRAAAYMKRKWDGDHYDALRDCLKALSLNPGHLKAHFRLARCLFELKYVAE 450

  Fly   315 ------------------------------------------------------------HDE-- 317
                                                                        .||
Zfish   451 ALECLNDFKGKFPEQAHSSACDALDKDIKAALFSKTDASDDKKGNSSIRFHNFSRKESIPEDEIV 515

  Fly   318 -----------YFNSCT----MKSCTFAGPQDELVVSGSDNFNMFIWRLEGVDLDEKNQWMETTP 367
                       |...|.    :|...|.|.:.:.:|||||:.:.|||..|..:|..
Zfish   516 LRERSFDYKHRYCGHCNTTTDIKEANFFGSKGQYIVSGSDDGSFFIWEKETTNLVR--------- 571

  Fly   368 VILAGHRSIVNQVRYNRERCLLASSGVEKIIKLWSPFAQQGWEGSLTQAEALPYCTRALYR--ES 430
             ||.|..||||.::.:...|.||:||::.:::||||               .|.|.....|  |.
Zfish   572 -ILQGDESIVNCLQPHPGHCFLATSGIDPVVRLWSP---------------RPECENENGRVVED 620

  Fly   431 SDHVSQDFSAR-STDEDQVMLAFFDTLVQHELESWSTVDNQNSSKSSTHTSTCSEASSPTEEPSD 494
            .:..:|....| :.|..:|||......:                         |..||...|.||
Zfish   621 MEGAAQANQRRMNADPLEVMLLNMGYRI-------------------------SGLSSRGAEGSD 660

  Fly   495 EED 497
            |||
Zfish   661 EED 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42233	NP_651899.2	WD40	<45..404	CDD:225201	124/619 (20%)
		WD40 repeat	56..91	CDD:293791	8/34 (24%)
		WD40	90..402	CDD:295369	110/572 (19%)
		WD40 repeat	100..142	CDD:293791	16/41 (39%)
		WD40 repeat	147..183	CDD:293791	8/37 (22%)
		WD40 repeat	191..225	CDD:293791	9/34 (26%)
		WD40 repeat	232..270	CDD:293791	12/80 (15%)
		WD40 repeat	278..371	CDD:293791	34/297 (11%)
		WD40 repeat	377..401	CDD:293791	7/23 (30%)
wdtc1	NP_001124078.1	WD40	<45..169	CDD:295369	41/128 (32%)
		WD40	48..>324	CDD:225201	69/280 (25%)
		WD40 repeat	57..93	CDD:293791	16/40 (40%)
		WD40 repeat	99..137	CDD:293791	8/37 (22%)
		WD40 repeat	143..184	CDD:293791	11/40 (28%)
		WD40 repeat	191..218	CDD:293791	6/26 (23%)
		WD40 repeat	238..277	CDD:293791	2/38 (5%)
		WD40 repeat	278..315	CDD:293791	8/36 (22%)
		TPR_11	365..429	CDD:290150	8/63 (13%)
		TPR repeat	365..389	CDD:276809	4/23 (17%)
		TPR repeat	394..427	CDD:276809	2/32 (6%)
		TPR_1	395..431	CDD:278916	2/35 (6%)
		TPR_16	401..466	CDD:290168	0/64 (0%)
		TPR repeat	432..456	CDD:276809	0/23 (0%)
		WD40	522..>605	CDD:295369	28/92 (30%)
		WD40 repeat	534..574	CDD:293791	14/49 (29%)
		WD40	<541..>605	CDD:225201	25/73 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920