DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42233 and dcaf6

DIOPT Version :9

Sequence 1:	NP_651899.2	Gene:	CG42233 / 43754	FlyBaseID:	FBgn0250755	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	XP_005167897.1	Gene:	dcaf6 / 564498	ZFINID:	ZDB-GENE-090206-2	Length:	988	Species:	Danio rerio

Alignment Length:	825	Identity:	164/825 - (19%)
Similarity:	288/825 - (34%)	Gaps:	235/825 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 RERLSAAQNLYQRNLTGHYGCVNALEFSSGGQFLASGGDDKRVLLWN-IDRELVSKLGKPRSMNE 141
            |.:|.|..|:       |.||||.:.::..|:::.||.||..:::.| .:|::.:      ::..
Zfish    37 RLKLEAVLNV-------HDGCVNTISWNDTGEYILSGSDDTNLVITNPYNRKVKT------TIRS 88

  Fly   142 KHASNIFCLGF--DTQNSYIFSGGNDDLVIQHDLETGKILN---HFS-HDGPVYGLSVDRISGHL 200
            .|.:|||...|  .|.:..|.|...|.::.....|..:.:|   .|: |.|..|.:.......:.
Zfish    89 GHRANIFSAKFMPHTNDQQIVSCSGDGIIFYTHTEKSQEINRQCQFTCHYGTAYEIMTVPNDPYT 153

  Fly   201 LSVATEHGEILVYDLRAGKS------EPLAIAKFKTPFNAVEFHPLNGNFLATANAKRGAMLWDL 259
            .....|.|.:..:|||...|      :...:...:....::...||...:||...:.....::|
Zfish   154 FLSCGEDGTVRWFDLRMKTSCTKEDCKDDILINCRRAATSISICPLVPYYLAVGCSDSSVRIYD- 217

  Fly   260 RHHQQALCQYNYIPESPSCMSVRFNCNGTLLLTLHRRLPPILYSPGAPEPVATFYHDEYFNSCTM 324
            |.........||:....:.|.|||                      .|..::|       .||.:
Zfish   218 RRMLGTRATGNYMGRGTTGMCVRF----------------------VPAHLST-------KSCRV 253

  Fly   325 KSCTFAGPQDELVVSGSDNFNMFIW--------RLEGVDLDEKNQ--------------WMETTP 367
            .|..::....|::||.|.:: ::::        .|:|...:.:.:              |.:|.|
Zfish   254 TSLCYSEDGQEVLVSYSSDY-IYLFDPKDDQARELKGPSEERREELRQPPVKRLRLRGDWSDTGP 317

  Fly   368 VILAGHRSIVNQVRYNRERCLLASSGV------EKIIKLWSPFAQQGWEGSLTQAEALPYCTRAL 426
                  |:   :....|||....|..|      ..::..|...|.:. :.|..:.:..|..|.|
Zfish   318 ------RA---RPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEA-QSSRARPQTRPRGTAA- 371

  Fly   427 YRESSDHVSQDFSARSTDEDQVMLAFFDTLVQHELESWS-------------------TVDNQNS 472
                   .::..|:.:|.:.||........|. |||:.:                   :|.:.:|
Zfish   372 -------QAEGTSSETTAQAQVSSGVAAEGVM-ELETPTINPLPTPPAPAPPSEPLPKSVSSSSS 428

  Fly   473 SKSSTHTSTCSEASSPTEE-PSDEEDQDPQTD-RNQNEENVQDQDIDTPNVS-----ELSWQTY- 529
            ..|||.|:....:||..|. .|......|.|: ::|.|.........||:.:     |.:...|
Zfish   429 GSSSTVTAPPPSSSSSMESATSSSLLSSPDTEQKSQGEVTPTPSATPTPSATPTASREAALSEYG 493

  Fly   530 PNRI-FYLIAKKRRSLLQLA------------VRGTSRHPRNVDQLL------QRLIGEQKQAAT 575
            |:|: ..|:.::.:.||.|:            |..||....:..|..      ..::.:|.::.|
Zfish   494 PHRLPVSLVCRRLQRLLLLSDPPGQGRRTMPNVPMTSSSESSAQQATAAADSPSSVVNKQLRSMT 558

  Fly   576 QARISDWLEETQ----------RLFGD-------------DELPTTSAEAAAREQRRRDGVLLCR 617
                   |||.|          |:.||             :.:|:|||.:..
Zfish   559 -------LEEEQGVKSSGEAAVRVIGDQSTGVTEASPETTESVPSTSAPSLG------------- 603

  Fly   618 NRRTQEFKI-VETPKSRITQRTRKRKLRQLIQTTKHRRATGRPRTT----EMDEGS-----ASSD 672
               |....| |.||.......|.:..|      :.|....|...:|    ..||.|     |.|.
Zfish   604 ---TSPGNISVSTPSGSGRSGTAEPVL------SLHYSTEGTTTSTIKLDFTDEWSSPASGAKSS 659

  Fly   673 TGASYDSDEEETSSGDN--NNNNSNERESVRTDDDGDN-SSTTSLTSMEAQFSQA--------PS 726
            :|.....:.||:.|.:.  .:.:|:..:|..|.|.|.. ||:|....:.::.|.|        ||
Zfish   660 SGGQKSGELEESQSREEPPGHKSSSSSKSEPTPDGGQTASSSTEKPGISSKNSSASAPAPPGDPS 724

  Fly   727 TSSSFLFHQLESNNNSQHTSNQNHKALNGLIPDNCNTESTASTSS 771
            |:            ::.|.|.:...|.:..:.:.|.|...|.|:|
Zfish   725 TT------------DTGHPSEELQTAASEQLSEQCRTSENAGTAS 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42233	NP_651899.2	WD40	<45..404	CDD:225201	70/366 (19%)
		WD40 repeat	56..91	CDD:293791	4/12 (33%)
		WD40	90..402	CDD:295369	65/352 (18%)
		WD40 repeat	100..142	CDD:293791	8/42 (19%)
		WD40 repeat	147..183	CDD:293791	9/40 (23%)
		WD40 repeat	191..225	CDD:293791	6/39 (15%)
		WD40 repeat	232..270	CDD:293791	6/37 (16%)
		WD40 repeat	278..371	CDD:293791	18/114 (16%)
		WD40 repeat	377..401	CDD:293791	5/29 (17%)
dcaf6	XP_005167897.1	WD40	<39..>284	CDD:225201	57/288 (20%)
		WD40	40..>283	CDD:295369	57/286 (20%)
		WD40 repeat	52..89	CDD:293791	8/42 (19%)
		WD40 repeat	94..135	CDD:293791	9/40 (23%)
		WD40 repeat	145..178	CDD:293791	6/32 (19%)
		WD40 repeat	185..230	CDD:293791	7/45 (16%)
		WD40 repeat	253..279	CDD:293791	5/26 (19%)
		WD40	<833..919	CDD:295369
		WD40	<833..>919	CDD:225201
		WD40 repeat	894..920	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920