DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42233 and dcaf5

DIOPT Version :9

Sequence 1:	NP_651899.2	Gene:	CG42233 / 43754	FlyBaseID:	FBgn0250755	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001071020.1	Gene:	dcaf5 / 560257	ZFINID:	ZDB-GENE-060929-808	Length:	789	Species:	Danio rerio

Alignment Length:	784	Identity:	249/784 - (31%)
Similarity:	376/784 - (47%)	Gaps:	122/784 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 RNLRSLETRNLDVALSQRENILVAGH--LPSAIFRERLSAAQNLYQRNLTGHYGCVNALEFS-SG 107
            :..|....|:....||:|   .:.||  |.....|.|||...:||::::.||:|||||:||| :|
Zfish     2 KEARGCSMRSAVGFLSRR---TIDGHPQLKEEFQRRRLSGCSSLYKKDMLGHFGCVNAIEFSNNG 63

  Fly   108 GQFLASGGDDKRVLLWNIDRELVSKLGKPRSMNEKHASNIFCLGFDTQNSYIFSGGNDDLVIQHD 172
            ||:|.|||||:|||||::::.:.|: .||..:..:|.||||||.||:.|..:||||||:.||.||
Zfish    64 GQWLVSGGDDRRVLLWHMEKAIHSR-AKPMKLKGEHLSNIFCLAFDSTNKRVFSGGNDEQVILHD 127

  Fly   173 LETGKILNHFSHDGPVYGLSVDRISGHLLSVATEHGEILVYDLR-AGKSEPLAIAKFKTPFNAVE 236
            :|.|:.||.|.||..||||||..::.::.:.:::.|.:|::|.| ....||..:|.:.:.|::|.
Zfish   128 VERGETLNVFLHDDAVYGLSVSPVNDNVFASSSDDGRVLIWDTREPPHGEPFCLANYPSAFHSVM 192

  Fly   237 FHPLNGNFLATANAKRGAMLWDLRHHQQALCQYNYIPESPSCMSVRFNCNGTLLLTLHRRLPPIL 301
            |:|:....|||||:|.|..|||:|..:.:|.:|.......|.||||||..||.||.|.|||||:|
Zfish   193 FNPVEPRLLATANSKEGVGLWDIRKPRSSLLRYGGSLSLQSAMSVRFNSTGTQLLALRRRLPPVL 257

  Fly   302 YSPGAPEPVATFYHDEYFNSCTMKSCTFAGPQDELVVSGSDNFNMFIWRLEGVDLDEKNQWMETT 366
            |...:..|...|.:..||||||||||.|||.:|:.::||||:||:::||:            .|.
Zfish   258 YELHSRLPSFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRI------------PTD 310

  Fly   367 P-------------VILAGHRSIVNQVRYNRERCLLASSGVEKIIKLWSPFAQQGWEGSLTQAEA 418
            |             ::|.||||||||||:|....::.||||||:||:|||:.|   ..||...|.
Zfish   311 PEAGGAGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKVIKVWSPYKQ---PDSLGDLEG 372

  Fly   419 L-PYCTRALYR---------ESSDHVSQDFSARSTDEDQVMLAFFDTLVQHELESWSTVDNQNSS 473
            | ...:|:||.         .|...:|.|:.::|..||..|:||||:||:.|:|.||:..:.:.|
Zfish   373 LVEDKSRSLYTHEEYISLVLNSGTGLSHDYVSQSVQEDPRMMAFFDSLVRREIEGWSSDSDSDLS 437

  Fly   474 KSS-------THTSTCSEASSPTEEPSDEEDQDPQTDRNQNEENVQDQDIDTPNVSELSWQTYPN 531
            :.:       ...||.|..|:|....:      .....:.:.|:.....:..|:||. |.:|..:
Zfish   438 EGAILQLHARARRSTRSTRSTPRSPAA------VSAAHHSDSEHSSSSSLAGPDVSG-SERTDQD 495

  Fly   532 RIFYLIAKKRRSLLQLAVRGTSRH---PRNVDQLLQRLIGEQKQAATQARISDWLEETQRLFGDD 593
            |                 .|:.|:   || ....|..|:.|...::     ..||:...|    .
Zfish   496 R-----------------SGSQRNRARPR-ASAFLLDLVNEDSDSS-----GFWLDPMPR----P 533

  Fly   594 ELPTTSAEAAAREQRRRDGVLLCRNRRTQEFKIVETPKSRITQRTRKRKLRQLIQTTKHRRATG- 657
            ..|:....::........||....:..........:....:.:..|:.::||. ...:.||..|
Zfish   534 RSPSPRENSSLSSHASSAGVASSSSSSPSSSSSSSSSTDGVDEELRRSRMRQR-NAARWRRHIGF 597

  Fly   658 RPRTTEMDEGSASSDTG----ASYDSDEEETSSGD-----NNNNNSNERESVRTDDDGDNSSTTS 713
            .||.:.....||:..:.    :.:|.....:||||     .|........|..:|....:.....
Zfish   598 SPRDSAQTLHSATDSSNYPNISIHDQSSPSSSSGDEDRPFRNRGKQKPSPSHLSDRQSQSRCRRR 662

  Fly   714 LTSMEAQFSQAP----STSSSFLF---HQLESNNNSQH------------TSNQNHKALNGL--I 757
            :||..:.....|    .:.:.||.   .:||....|..            :|......:||.  |
Zfish   663 ITSSFSGAGDGPLERAKSRAGFLAESGEELERGRTSGEELSTVEDLNLTLSSRTTVAGVNGRPHI 727

  Fly   758 PDNC 761
            .:||
Zfish   728 DENC 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42233	NP_651899.2	WD40	<45..404	CDD:225201	165/374 (44%)
		WD40 repeat	56..91	CDD:293791	12/36 (33%)
		WD40	90..402	CDD:295369	149/326 (46%)
		WD40 repeat	100..142	CDD:293791	22/42 (52%)
		WD40 repeat	147..183	CDD:293791	21/35 (60%)
		WD40 repeat	191..225	CDD:293791	9/34 (26%)
		WD40 repeat	232..270	CDD:293791	16/37 (43%)
		WD40 repeat	278..371	CDD:293791	44/105 (42%)
		WD40 repeat	377..401	CDD:293791	14/23 (61%)
dcaf5	NP_001071020.1	WD40	47..396	CDD:225201	161/364 (44%)
		WD40	49..359	CDD:295369	149/322 (46%)
		WD40 repeat	103..138	CDD:293791	20/34 (59%)
		WD40 repeat	143..185	CDD:293791	13/41 (32%)
		WD40 repeat	190..227	CDD:293791	16/36 (44%)
		WD40 repeat	234..270	CDD:293791	19/35 (54%)
		WD40 repeat	278..327	CDD:293791	20/60 (33%)
		WD40 repeat	334..358	CDD:293791	14/23 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580148
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4227
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	347	1.000	Inparanoid score	I2277
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	1	1.000	-	-		FOG0008129
OrthoInspector	1	1.000	-	-		oto40161
orthoMCL	1	0.900	-	-		OOG6_107257
Panther	1	1.100	-	-	LDO	PTHR15574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3879
SonicParanoid	1	1.000	-	-		X6083
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.790