DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG42233 and DCAF8

DIOPT Version :9

Sequence 1:NP_651899.2 Gene:CG42233 / 43754 FlyBaseID:FBgn0250755 Length:773 Species:Drosophila melanogaster
Sequence 2:NP_056541.2 Gene:DCAF8 / 50717 HGNCID:24891 Length:597 Species:Homo sapiens


Alignment Length:569 Identity:132/569 - (23%)
Similarity:211/569 - (37%) Gaps:186/569 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 VQRK-------PGDGARKMSLWRNLRSLETRNLDVALSQRENILVAGHLPSAIFRERLSAAQNLY 88
            ||||       ..|..|.:..|   .|.||..|.....|.        ||:...||..|:|:.:|
Human   118 VQRKRANRDQDSSDDERALEDW---VSSETSALPRPRWQA--------LPALRERELGSSARFVY 171

  Fly    89 --------------QRNLTGHYGCVNALEFSSGGQFLASGGDDKRVLLWN-IDRELVSKLGKPRS 138
                          |..|.||.||||.|.|:..|.:||||.||.:|::|: :.|:.|      ..
Human   172 EACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPV------LD 230

  Fly   139 MNEKHASNIFCLGFDTQNSYIFSGGNDDLVI---------------QHDLETGKILNHFSHDGPV 188
            ....|.||:|      |..::.:.|:..|.:               |....|.::.   .|.|..
Human   231 FESGHKSNVF------QAKFLPNSGDSTLAMCARDGQVRVAELSATQCCKNTKRVA---QHKGAS 286

  Fly   189 YGLSVDRISGHLLSVATEHGEILVYDLRAGK-SEPLAIAK---FKTPFNAVEFHPLNGNFLATAN 249
            :.|:::..|......|.|...:...|||..: :..|.:.|   .|.....:..:|.|.:..|...
Human   287 HKLALEPDSPCTFLSAGEDAVVFTIDLRQDRPASKLVVTKEKEKKVGLYTIYVNPANTHQFAVGG 351

  Fly   250 AKRGAMLWDLRHHQQ--------ALCQYNYIPESPSCMSVRFNCNGTLLLTLHRRLPPILYSPGA 306
            ..:...::|.|...:        ..|.::.: .|.|  .....|              ::||...
Human   352 RDQFVRIYDQRKIDENENNGVLKKFCPHHLV-NSES--KANITC--------------LVYSHDG 399

  Fly   307 PEPVATFYHDE---------------------YFNSCTMKSCTFAGPQDELVVSGSDNFNMFIWR 350
            .|.:|: |:||                     :.|:.|:|...|.||:.|.||||||..::|:| 
Human   400 TELLAS-YNDEDIYLFNSSHSDGAQYVKRYKGHRNNATVKGVNFYGPKSEFVVSGSDCGHIFLW- 462

  Fly   351 LEGVDLDEKN-----QWMETTPVILAGHR-SIVNQVRYNRERCLLASSGVEKIIKLWSPFAQQGW 409
                   ||:     |:||       |.: .:||.:..:....:||:||::..:|:|:|.|:...
Human   463 -------EKSSCQIIQFME-------GDKGGVVNCLEPHPHLPVLATSGLDHDVKIWAPTAEAST 513

  Fly   410 EGSLTQAEALPYCTRALYRESSDHVSQDFSARSTDEDQV-MLAFFDT----LVQHELES------ 463
            |  ||..:              |.:.:  :.|..|||.: ....||:    .:.|.|..      
Human   514 E--LTGLK--------------DVIKK--NKRERDEDSLHQTDLFDSHMLWFLMHHLRQRRHHRR 560

  Fly   464 W------STVDNQNSSKSSTHTSTCSEASSPTEEPSDEEDQDPQTDRNQ 506
            |      :|..:.:.|.||:.||              :|::.|  ||.|
Human   561 WREPGVGATDADSDESPSSSDTS--------------DEEEGP--DRVQ 593

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42233NP_651899.2 WD40 <45..404 CDD:225201 100/427 (23%)
WD40 repeat 56..91 CDD:293791 10/48 (21%)
WD40 90..402 CDD:295369 85/366 (23%)
WD40 repeat 100..142 CDD:293791 14/42 (33%)
WD40 repeat 147..183 CDD:293791 6/50 (12%)
WD40 repeat 191..225 CDD:293791 8/34 (24%)
WD40 repeat 232..270 CDD:293791 6/45 (13%)
WD40 repeat 278..371 CDD:293791 28/118 (24%)
WD40 repeat 377..401 CDD:293791 7/23 (30%)
DCAF8NP_056541.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..147 10/31 (32%)
Nuclear export signal. /evidence=ECO:0000269|PubMed:22500989 39..50
Nuclear localization signal. /evidence=ECO:0000269|PubMed:22500989 114..122 3/3 (100%)
WD40 189..506 CDD:392136 85/364 (23%)
WD 1 191..230 19/44 (43%)
WD40 repeat 198..234 CDD:293791 13/41 (32%)
WD 2 234..275 8/46 (17%)
WD40 repeat 240..281 CDD:293791 6/49 (12%)
WD 3 281..321 9/39 (23%)
WD40 repeat 286..327 CDD:293791 8/40 (20%)
WD 4 329..369 6/39 (15%)
WD40 repeat 335..383 CDD:293791 6/48 (13%)
WD 5 385..424 9/55 (16%)
WD40 repeat 390..429 CDD:293791 8/53 (15%)
WD 6 432..472 17/47 (36%)
WD40 repeat 437..474 CDD:293791 16/44 (36%)
WD 7 476..515 11/40 (28%)
WD40 repeat 481..505 CDD:293791 7/23 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 558..597 12/52 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1270484at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

Return to query results.
Submit another query.