DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42233 and Dcaf8

DIOPT Version :9

Sequence 1:	NP_651899.2	Gene:	CG42233 / 43754	FlyBaseID:	FBgn0250755	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001014253.1	Gene:	Dcaf8 / 364050	RGDID:	1308513	Length:	591	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	130/557 - (23%)
Similarity:	206/557 - (36%)	Gaps:	177/557 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VQRK-------PGDGARKMSLWRNLRSLETRNLDVALSQRENILVAGHLPSAIFRERLSAAQNLY 88
            ||||       ..|..|.:..|   .|.||..|.....|.        ||:...||..|:|:.:|
  Rat   112 VQRKRASRDQDSSDDERALEDW---VSSETTALPRPRWQA--------LPALRERELGSSARFVY 165

  Fly    89 --------------QRNLTGHYGCVNALEFSSGGQFLASGGDDKRVLLWN-IDRELVSKLGKPRS 138
                          |..|.||.||||.|.|:..|.:||||.||.:|::|: :.|:.|      ..
  Rat   166 EACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPV------LD 224

  Fly   139 MNEKHASNIFCLGFDTQNSYIFSGGNDDLVI---------------QHDLETGKILNHFSHDGPV 188
            ....|.||:|      |..::.:.|:..|.:               |....|.::.   .|.|..
  Rat   225 FESGHKSNVF------QAKFLPNSGDSTLAMCARDGQVRVAELSATQCCKNTKRVA---QHKGAS 280

  Fly   189 YGLSVDRISGHLLSVATEHGEILVYDLRAGK-SEPLAIAK---FKTPFNAVEFHPLNGNFLATAN 249
            :.|:::..|......|.|...:...|||..: :..|.:.|   .|.....:..:|.|.:..|...
  Rat   281 HKLALEPDSPCTFLSAGEDAVVFTIDLRQDRPASKLVVTKEKEKKVGLYTIYVNPANTHQFAVGG 345

  Fly   250 AKRGAMLWDLRHHQQALCQYNYIPESPSCMSVRFNCNGTLLLTLHRRLPP--------------I 300
            ..:...::|.|.          |.|:.:        ||.|     ::..|              :
  Rat   346 RDQFVRIYDQRK----------IDENEN--------NGVL-----KKFCPHHLVNSESKANITCL 387

  Fly   301 LYSPGAPEPVATFYHDE---------------------YFNSCTMKSCTFAGPQDELVVSGSDNF 344
            :||....|.:|: |:||                     :.|:.|:|...|.||:.|.||||||..
  Rat   388 VYSHDGTELLAS-YNDEDIYLFNSSHSDGAQYIKRYKGHRNNATVKGVNFYGPKSEFVVSGSDCG 451

  Fly   345 NMFIWRLEGVDLDEKN-----QWMETTPVILAGHR-SIVNQVRYNRERCLLASSGVEKIIKLWSP 403
            ::|:|        ||:     |:||       |.: .:||.:..:....:||:||::..:|:|:|
  Rat   452 HIFLW--------EKSSCQIIQFME-------GDKGGVVNCLEPHPHLPVLATSGLDHDVKIWAP 501

  Fly   404 FAQQGWEGSLTQAEALPYCTRALYRESSDHVSQDFSARSTDEDQVMLAFFDTLVQHELESWSTVD 468
            .|:...|  ||..:              |.:.:  :.|..|||.  |...|....|.|  |..:.
  Rat   502 TAEASTE--LTGLK--------------DVIKK--NKRERDEDS--LHHTDLFDSHML--WFLMH 544

  Fly   469 NQNSSKSSTH--------TSTCSEASSPTEEPSDEED 497
            :....:....        |...|:.|..:.:.||||:
  Rat   545 HLRQRRHHRRWREPGVGATDADSDESPSSSDTSDEEE 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42233	NP_651899.2	WD40	<45..404	CDD:225201	102/433 (24%)
		WD40 repeat	56..91	CDD:293791	10/48 (21%)
		WD40	90..402	CDD:295369	87/372 (23%)
		WD40 repeat	100..142	CDD:293791	14/42 (33%)
		WD40 repeat	147..183	CDD:293791	6/50 (12%)
		WD40 repeat	191..225	CDD:293791	8/34 (24%)
		WD40 repeat	232..270	CDD:293791	5/37 (14%)
		WD40 repeat	278..371	CDD:293791	31/132 (23%)
		WD40 repeat	377..401	CDD:293791	7/23 (30%)
Dcaf8	NP_001014253.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..140		10/30 (33%)
		Nuclear export signal. /evidence=ECO:0000250\|UniProtKB:Q5TAQ9	39..50
		WD40	183..500	CDD:295369	87/370 (24%)
		WD40	183..>499	CDD:225201	87/369 (24%)
		WD 1	185..224		19/44 (43%)
		WD40 repeat	192..228	CDD:293791	13/41 (32%)
		WD 2	228..269		8/46 (17%)
		WD40 repeat	234..275	CDD:293791	6/49 (12%)
		WD 3	275..315		9/39 (23%)
		WD40 repeat	280..321	CDD:293791	8/40 (20%)
		WD 4	323..363		8/49 (16%)
		WD40 repeat	329..377	CDD:293791	11/70 (16%)
		WD 5	379..418		7/39 (18%)
		WD40 repeat	384..423	CDD:293791	7/39 (18%)
		WD 6	426..466		17/47 (36%)
		WD40 repeat	431..468	CDD:293791	16/44 (36%)
		WD 7	470..509		11/40 (28%)
		WD40 repeat	475..499	CDD:293791	7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	552..591		7/30 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920