DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42233 and Dcaf5

DIOPT Version :9

Sequence 1:	NP_651899.2	Gene:	CG42233 / 43754	FlyBaseID:	FBgn0250755	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_796241.3	Gene:	Dcaf5 / 320808	MGIID:	2444785	Length:	946	Species:	Mus musculus

Alignment Length:	796	Identity:	263/796 - (33%)
Similarity:	392/796 - (49%)	Gaps:	156/796 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RKMSLWRNLRS----LETRNL--DVALSQRENILVAGHLPSAIFRERLSAAQNLYQRNLTGHYGC 98
            |:..|..::||    |..|.|  |..|:|            ...|.||...:|||:::|.||:||
Mouse     3 RRAGLGGSMRSVVGFLSQRGLHGDPLLTQ------------DFQRRRLRGCRNLYKKDLLGHFGC 55

  Fly    99 VNALEFS-SGGQFLASGGDDKRVLLWNIDRELVSKLGKPRSMNEKHASNIFCLGFDTQNSYIFSG 162
            |||:||| :|||:|.|||||:|||||::::.:.|:: ||..:..:|.||||||.|::.|:.:|||
Mouse    56 VNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRV-KPIQLKGEHHSNIFCLAFNSGNTKVFSG 119

  Fly   163 GNDDLVIQHDLETGKILNHFSHDGPVYGLSVDRISGHLLSVATEHGEILVYDLR-AGKSEPLAIA 226
            |||:.||.||:|:.:.|:.|:|:..||||||..::.::.:.:::.|.:|::|:| :...||..:|
Mouse   120 GNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPFCLA 184

  Fly   227 KFKTPFNAVEFHPLNGNFLATANAKRGAMLWDLRHHQQALCQYNYIPESPSCMSVRFNCNGTLLL 291
            .:.:.|::|.|:|:....|||||:|.|..|||:|..|.:|.:|.......|.||||||.|||.||
Mouse   185 NYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLL 249

  Fly   292 TLHRRLPPILYSPGAPEPVATFYHDEYFNSCTMKSCTFAGPQDELVVSGSDNFNMFIWRLE---- 352
            .|.|||||:||...:..||..|.:..||||||||||.|||.:|:.::||||:||:::|::.
Mouse   250 ALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWKIPADPE 314

  Fly   353 --GVDLDEKNQWMETTPVILAGHRSIVNQVRYNRERCLLASSGVEKIIKLWSPFAQQGWEGSL-- 413
              |:.......:|     :|.||||||||||:|....::.|||||||||:|||:.|.|..|.|
Mouse   315 AGGIGRVVNGAFM-----VLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDG 374

  Fly   414 ----------TQAEALPYCTRALYRESSDHVSQDFSARSTDEDQVMLAFFDTLVQHELESWSTVD 468
                      |..|.:     :|...|...:|.|::.:|..||..|:||||:||:.|:|.||:..
Mouse   375 RIEDDSRCLYTHEEYI-----SLVLNSGSGLSHDYANQSVQEDPRMMAFFDSLVRREIEGWSSDS 434

  Fly   469 NQNSSKS------------STHTSTCSEASSPTEEPSDEEDQDPQTDRN-QNEENVQDQDIDTPN 520
            :.:.|:|            |.:|.:.|.||.|...|       |..|.: .|..::....:.|.|
Mouse   435 DSDLSESTILQLHAGVSERSGYTDSESSASLPRSPP-------PTVDESADNAFHLGPLRVTTTN 492

  Fly   521 VSELSWQTYPNRIFYLIAKKRRSLLQLAVRGTSRHPRNVDQLLQRLIGEQKQAATQARISDWLEE 585
                                       ||..|...|...|           .::.|.|:|
Mouse   493 ---------------------------AVASTPATPTCED-----------ASSRQQRLS----- 514

  Fly   586 TQRLFGDDELPTTSAEAAARE---QRRRDGVLLCRNRRTQEFKIVETPKSRITQRTRKRKLRQLI 647
            ..|.:.|..|...|.|:.:.|   :...|..|..|.|.........:|.|. |....:.:|.|..
Mouse   515 ALRRYQDKRLLALSNESDSEENVCEAELDTDLFPRPRSPSPEDGSSSPSSS-TSSEDEEELNQRR 578

  Fly   648 QTTKHRRATGRPRTTEMDE---GSASSDTGASYDSDEEETSSGDNNNNNSNERESVRTDD---DG 706
            .||:.|.|..|.:.|..||   |.|.|          ..|..|::|    .:...::.||   ..
Mouse   579 ATTRQRNAMRRRQKTARDERPTGPAKS----------TNTYIGEDN----YDYPQIKVDDLSPSP 629

  Fly   707 DNSSTTSLTSMEAQFSQAPSTSS-----------------SFLFHQLESNNNSQHTSNQNHKALN 754
            |:|...|.::::.|.|:||..::                 |::.:   |||....||....:|..
Mouse   630 DSSPERSASTLDVQPSRAPPAANMESVERKIYKAYKWLRCSYISY---SNNKDGETSLMAEEADE 691

  Fly   755 GLIPDNCNTESTASTS 770
            |....:.....|.|:|
Mouse   692 GRAGTSHKDNPTPSSS 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42233	NP_651899.2	WD40	<45..404	CDD:225201	165/372 (44%)
		WD40 repeat	56..91	CDD:293791	10/36 (28%)
		WD40	90..402	CDD:295369	149/319 (47%)
		WD40 repeat	100..142	CDD:293791	22/42 (52%)
		WD40 repeat	147..183	CDD:293791	18/35 (51%)
		WD40 repeat	191..225	CDD:293791	9/34 (26%)
		WD40 repeat	232..270	CDD:293791	17/37 (46%)
		WD40 repeat	278..371	CDD:293791	45/98 (46%)
		WD40 repeat	377..401	CDD:293791	15/23 (65%)
Dcaf5	NP_796241.3	WD40	16..>361	CDD:225201	161/362 (44%)
		WD40	49..361	CDD:295369	149/317 (47%)
		WD 1	51..91		25/39 (64%)
		WD40 repeat	57..98	CDD:293791	22/41 (54%)
		WD 2	99..139		21/39 (54%)
		WD40 repeat	104..139	CDD:293791	18/34 (53%)
		WD 3	140..180		11/39 (28%)
		WD40 repeat	146..187	CDD:293791	12/40 (30%)
		WD 4	185..225		16/39 (41%)
		WD40 repeat	191..228	CDD:293791	16/36 (44%)
		WD40 repeat	236..323	CDD:293791	44/86 (51%)
		WD 5	277..317		20/39 (51%)
		WD 6	331..370		25/38 (66%)
		WD40 repeat	336..360	CDD:293791	15/23 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..478		9/35 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	527..656		35/143 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..860		10/33 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..946
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836620
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4227
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	359	1.000	Inparanoid score	I2203
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008129
OrthoInspector	1	1.000	-	-		oto93528
orthoMCL	1	0.900	-	-		OOG6_107257
Panther	1	1.100	-	-	LDO	PTHR15574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3879
SonicParanoid	1	1.000	-	-		X6083
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.780