DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42233 and Dcaf5

DIOPT Version :9

Sequence 1:	NP_651899.2	Gene:	CG42233 / 43754	FlyBaseID:	FBgn0250755	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001094188.1	Gene:	Dcaf5 / 314273	RGDID:	1306535	Length:	946	Species:	Rattus norvegicus

Alignment Length:	819	Identity:	259/819 - (31%)
Similarity:	390/819 - (47%)	Gaps:	202/819 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RKMSLWRNLRS----LETRNL--DVALSQRENILVAGHLPSAIFRERLSAAQNLYQRNLTGHYGC 98
            |:..|..::||    |..|.|  |..|:|            ...|.||...:|||:::|.||:||
  Rat     3 RRAGLGGSMRSVVGFLSQRGLHGDPLLTQ------------DFQRRRLRGCRNLYKKDLLGHFGC 55

  Fly    99 VNALEFS-SGGQFLASGGDDKRVLLWNIDRELVSKLGKPRSMNEKHASNIFCLGFDTQNSYIFSG 162
            |||:||| :|||:|.|||||:|||||::::.:.|:: ||..:..:|.||||||.|::.|:.:|||
  Rat    56 VNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRV-KPIQLKGEHHSNIFCLAFNSGNTKVFSG 119

  Fly   163 GNDDLVIQHDLETGKILNHFSHDGPVYGLSVDRISGHLLSVATEHGEILVYDLR-AGKSEPLAIA 226
            |||:.||.||:|:.:.|:.|:|:..||||||..::.::.:.:::.|.:|::|:| :...||..:|
  Rat   120 GNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPFCLA 184

  Fly   227 KFKTPFNAVEFHPLNGNFLATANAKRGAMLWDLRHHQQALCQYNYIPESPSCMSVRFNCNGTLLL 291
            .:.:.|::|.|:|:....|||||:|.|..|||:|..|.:|.:|.......|.||||||.|||.||
  Rat   185 NYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLL 249

  Fly   292 TLHRRLPPILYSPGAPEPVATFYHDEYFNSCTMKSCTFAGPQDELVVSGSDNFNMFIWRLEGVDL 356
            .|.|||||:||...:..||..|.:..||||||||||.|||.:|:.::||||:||:::|:   |..
  Rat   250 ALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWK---VPA 311

  Fly   357 DEK----NQWMETTPVILAGHRSIVNQVRYNRERCLLASSGVEKIIKLWSPFAQQGWEGSL---- 413
            |.:    .:.:....::|.||||||||||:|....::.|||||||||:|||:.|.|..|.|
  Rat   312 DPEAGGLGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRI 376

  Fly   414 --------TQAEALPYCTRALYRESSDHVSQDFSARSTDEDQVMLAFFDTLVQHELESWSTVDNQ 470
                    |..|.:     :|...|...:|.|::.:|..||..|:||||:||:.|:|.||:..:.
  Rat   377 EDDSRCLYTHEEYI-----SLVLNSGSGLSHDYANQSVQEDPRMMAFFDSLVRREIEGWSSDSDS 436

  Fly   471 NSSKS------------STHTSTCSEASSPTEEPSDEEDQDPQTDRNQNEENVQDQDIDTPNVSE 523
            :.|:|            |.:|.:.|.||.|...|                          |.|.|
  Rat   437 DLSESTILQLHAGVSERSGYTDSESSASLPRSPP--------------------------PTVDE 475

  Fly   524 LSWQTYPNRIFYLIAKKRRSLLQLAVRGTSRHPRNVDQLLQRLIGEQKQAATQARISDWLEETQR 588
            .:     :..|:|                               |..:...|.|.:|
  Rat   476 SA-----DNAFHL-------------------------------GPLRVTTTSAVVS-------- 496

  Fly   589 LFGDDELPTTSA--EAAAREQRRRDGVLLCRNRRTQEFKIVETPKSRITQRTRKRKLRQLIQTTK 651
                  .|.|..  :||:|:||      |...||.|:.:::.......::       ..:.:...
  Rat   497 ------TPATPTCEDAASRQQR------LSALRRYQDKRLLALSNESDSE-------ENVCEAEL 542

  Fly   652 HRRATGRPRTTEMDEGSASSDTGASYDSDEEETSSGDNNNNNSN-----------ERES------ 699
            ......|||:...::||:||.:..| ..||||.:....|....|           ||.:
  Rat   543 DTDLFPRPRSPSPEDGSSSSSSSTS-SEDEEELNQRRANTRQRNAMRRRQKTAREERPNAPVKST 606

  Fly   700 -------------VRTDD--DGDNSSTTSLTS-MEAQFSQAPSTSS-----------------SF 731
                         ::.||  ...|||....|| ::.|.|:||..::                 |:
  Rat   607 NTYIGEDNYDYPQIKVDDLSSSPNSSPERSTSTLDIQPSRAPPAANMESVERKIYKAYKWLRYSY 671

  Fly   732 LFHQLESNNNSQHTSNQNHKALNGLIPDNCNTESTASTS 770
            :.:   |||....||....:|..|....:.....|.|:|
  Rat   672 ISY---SNNKDGETSLVTEEADEGRAGTSHKDNPTPSSS 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42233	NP_651899.2	WD40	<45..404	CDD:225201	165/370 (45%)
		WD40 repeat	56..91	CDD:293791	10/36 (28%)
		WD40	90..402	CDD:295369	149/317 (47%)
		WD40 repeat	100..142	CDD:293791	22/42 (52%)
		WD40 repeat	147..183	CDD:293791	18/35 (51%)
		WD40 repeat	191..225	CDD:293791	9/34 (26%)
		WD40 repeat	232..270	CDD:293791	17/37 (46%)
		WD40 repeat	278..371	CDD:293791	45/96 (47%)
		WD40 repeat	377..401	CDD:293791	15/23 (65%)
Dcaf5	NP_001094188.1	WD40	49..361	CDD:421866	149/315 (47%)
		WD40 repeat	57..98	CDD:293791	22/41 (54%)
		WD40 repeat	104..139	CDD:293791	18/34 (53%)
		WD40 repeat	146..187	CDD:293791	12/40 (30%)
		WD40 repeat	191..228	CDD:293791	16/36 (44%)
		WD40 repeat	236..323	CDD:293791	45/89 (51%)
		WD40 repeat	336..360	CDD:293791	15/23 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4227
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008129
OrthoInspector	1	1.000	-	-		oto97070
orthoMCL	1	0.900	-	-		OOG6_107257
Panther	1	1.100	-	-	LDO	PTHR15574
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6083
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.700