DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42233 and WDTC1

DIOPT Version :9

Sequence 1:	NP_651899.2	Gene:	CG42233 / 43754	FlyBaseID:	FBgn0250755	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_001263181.1	Gene:	WDTC1 / 23038	HGNCID:	29175	Length:	677	Species:	Homo sapiens

Alignment Length:	643	Identity:	124/643 - (19%)
Similarity:	182/643 - (28%)	Gaps:	316/643 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 KMSLWRNL--RSLETRNLDVALSQRENILVAGHLPSAIFRERLSAAQNLYQRNLTGHYGCVNALE 103
            |:::.|:|  |.::.|.   |||.....    |:.....| ||.     .:..|.||.||||.||
Human     3 KVNITRDLIRRQIKERG---ALSFERRY----HVTDPFIR-RLG-----LEAELQGHSGCVNCLE 54

  Fly   104 FSSGGQFLASGGDDKRVLLWNIDRELVSKLGKPRSMNEKHASNIFCLGF--DTQNSYIFSGGNDD 166
            ::..|..||||.||:..::|:   .|..|  |..||:..|.:|||.:.|  ...:..:.:|..|.
Human    55 WNEKGDLLASGSDDQHTIVWD---PLHHK--KLLSMHTGHTANIFSVKFLPHAGDRILITGAADS 114

  Fly   167 LVIQHDLETGKILNHF-SHDGPVYGLSVDRISGHLLSVATEHGEILVYDLRAGKSE--------- 221
            .|..|||...:.::.| .|...|..::...:..:....|.|.|.|..||||.....
Human   115 KVHVHDLTVKETIHMFGDHTNRVKRIATAPMWPNTFWSAAEDGLIRQYDLRENSKHSEVLIDLTE 179

  Fly   222 ---PLAIAKFKTPFNAVEFHPLNGNFLATANAKRGAMLWDLR---HHQQALCQ------------ 268
               .|..||..|      .:|.:.|.||...:.....|:|:|   :|::::.|
Human   180 YCGQLVEAKCLT------VNPQDNNCLAVGASGPFVRLYDIRMIHNHRKSMKQSPSAGVHTFCDR 238

  Fly   269 -----------------------YN---------YIPESPSCMSVRFNCNG-------------- 287
                                   ||         |:..||:...:..|..|
Human   239 QKPLPDGAAQYYVAGHLPVKLPDYNNRLRVLVATYVTFSPNGTELLVNMGGEQVYLFDLTYKQRP 303

  Fly   288 -TLLLT----------------------------LHR----------------RLPPI------- 300
             |.||.                            ||.                .|||.
Human   304 YTFLLPRKCHSSGEVQNGKMSTNGVSNGVSNGLHLHSNGFRLPESRGHVSPQVELPPYLERVKQQ 368

  Fly   301 ---------------LYS----------------------------------------------- 303
                           |||
Human   369 ANEAFACQQWTQAIQLYSKAVQRAPHNAMLYGNRAAAYMKRKWDGDHYDALRDCLKAISLNPCHL 433

  Fly   304 -------------------------------------------------------------PGAP 307
                                                                         ||..
Human   434 KAHFRLARCLFELKYVAEALECLDDFKGKFPEQAHSSACDALGRDITAALFSKNDGEEKKGPGGG 498

  Fly   308 EPV---------------------ATFYHDEYFNSCT----MKSCTFAGPQDELVVSGSDNFNMF 347
            .||                     :..|...|...|.    :|...|.|...:.:|||||:.:.|
Human   499 APVRLRSTSRKDSISEDEMVLRERSYDYQFRYCGHCNTTTDIKEANFFGSNAQYIVSGSDDGSFF 563

  Fly   348 IWRLEGVDLDEKNQWMETTPV--ILAGHRSIVNQVRYNRERCLLASSGVEKIIKLWSP 403
            ||        ||    |||.:  :|.|..||||.::.:...|.||:||::.:::||:|
Human   564 IW--------EK----ETTNLVRVLQGDESIVNCLQPHPSYCFLATSGIDPVVRLWNP 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42233	NP_651899.2	WD40	<45..404	CDD:225201	123/639 (19%)
		WD40 repeat	56..91	CDD:293791	7/34 (21%)
		WD40	90..402	CDD:295369	110/589 (19%)
		WD40 repeat	100..142	CDD:293791	16/41 (39%)
		WD40 repeat	147..183	CDD:293791	10/38 (26%)
		WD40 repeat	191..225	CDD:293791	9/45 (20%)
		WD40 repeat	232..270	CDD:293791	9/75 (12%)
		WD40 repeat	278..371	CDD:293791	36/308 (12%)
		WD40 repeat	377..401	CDD:293791	7/23 (30%)
WDTC1	NP_001263181.1	WD40	<34..163	CDD:421866	43/139 (31%)
		WD 1	45..84		19/43 (44%)
		WD40 repeat	51..88	CDD:293791	16/41 (39%)
		WD 2	88..129		11/40 (28%)
		WD40 repeat	93..131	CDD:293791	9/37 (24%)
		WD 3	132..172		10/39 (26%)
		WD40 repeat	138..178	CDD:293791	8/39 (21%)
		WD 4	182..222		12/45 (27%)
		WD40 repeat	232..271	CDD:293791	2/38 (5%)
		WD 5	265..305		5/39 (13%)
		TPR 1	362..395		3/32 (9%)
		TPR repeat	366..390	CDD:276809	3/23 (13%)
		PLN03088	368..>438	CDD:215568	3/69 (4%)
		TPR repeat	395..428	CDD:276809	0/32 (0%)
		TPR 2	397..432		0/34 (0%)
		TPR repeat	433..457	CDD:276809	0/23 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	487..509		4/21 (19%)
		WD 6	535..575		16/51 (31%)
		WD40 repeat	537..577	CDD:293791	16/51 (31%)
		WD40	<546..>626	CDD:421866	28/76 (37%)
		WD 7	578..617		13/32 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920