DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42233 and R11D1.1

DIOPT Version :9

Sequence 1:	NP_651899.2	Gene:	CG42233 / 43754	FlyBaseID:	FBgn0250755	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	NP_506171.2	Gene:	R11D1.1 / 179738	WormBaseID:	WBGene00011242	Length:	622	Species:	Caenorhabditis elegans

Alignment Length:	725	Identity:	180/725 - (24%)
Similarity:	280/725 - (38%)	Gaps:	215/725 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 NLDVALS--------------QRENILVAGHLPSAI------FRERLSAAQNLYQRNLTGHYGCV 99
            |:|:.:|              |||    .|.:.|.:      |:.|     ...|:::..|.||:
Worm    14 NMDIEISKSTNNQFKIESFLCQRE----IGSVKSVVKTFRPDFQHR-----PFCQKDVREHTGCI 69

  Fly   100 NALEFSSGGQFLASGGDDKRVLLWNIDRELVSKLGKPRS-MNEKHASNIFCLGFDTQNSYIFSGG 163
            |||:||...:||||||||....:||:|..:|.|..||.. |...|.||||.|.||.:|.:::||.
Worm    70 NALQFSHNDRFLASGGDDMHGRVWNVDELMVRKTPKPIGVMEHPHRSNIFSLEFDLENRFLYSGE 134

  Fly   164 NDDLVIQHDLETGK---ILNHFSHDGPVYGLSVDRISGHLLSVATEHGEILVYDLRAGKSEPLAI 225
            ....||:||:||.:   :.|..::.|.||.:. ...:.:.|.|.|....:...|.| .:..|:::
Worm   135 RWGTVIKHDIETKQSIYVANENNNRGDVYHMD-QHPTDNTLIVVTRAKLVSFIDNR-DRQNPISL 197

  Fly   226 ---AKFKTPFNAVEFHPLNGNFLATANAKRGAMLWDLRHHQQALCQ---YNYIP-ESPSCMSVRF 283
               |.....|...||||.....:...:...|..::|.|...:.:.|   :..:| |:...|...:
Worm   198 VLPANSGKNFYTAEFHPETPALILVNSETGGPNVFDRRMQARPVYQRSMFKGLPQENTEWMGSLW 262

  Fly   284 NCNGTLLLTLHRRLPP-----------ILYSPGAPEPVATFYHDEYFNSCTMKSCTFAGPQDELV 337
            :.:|...:::.|...|           :|.|...|        :.|.|..|:||.||.  .|..|
Worm   263 SPSGNQFMSIRRGKCPLYFDFISQRCFVLKSDHNP--------NGYCNIKTIKSMTFI--DDYTV 317

  Fly   338 VSGSDNFNMFIWRLE-----------GVDLDE--KNQWMETTPVILAGHRSIVNQVRYNRERCLL 389
            .:|||::.:.||:|.           |.|.:|  ...::|....:|.||||:.||||:::...||
Worm   318 ATGSDHWGIHIWKLPRANDSYGFTQIGHDEEEMPSEIFIEKELTVLRGHRSVPNQVRFSQHNNLL 382

  Fly   390 ASSGVEKIIKLWSPFAQQGWEGSLTQAEALPYCTRALYRESSDHVSQDFSA-----RSTDEDQVM 449
            .|||||...||||       :..|..:..||:       |...|.:.|.||     |..:|.:|:
Worm   383 VSSGVENSFKLWS-------DHRLPWSYDLPF-------ERRPHGTYDLSAEEECLREMEERRVV 433

  Fly   450 LAFFDTLVQHELES---WSTV---DNQNSSKSSTHTSTCSEASSPTEEPSDEEDQDPQTDRNQNE 508
            ....|  :..|::.   |..:   |.:.:....|     .|...|.....||||.:..:  :::.
Worm   434 EDALD--LNGEMDGRACWRDIFGGDARTAEDRDT-----LEMFDPRGHGDDEEDVEESS--SEDS 489

  Fly   509 ENVQDQDIDTPNVSELSWQTYPNRIFYLIAKKRRSLLQLAVRGTSRHPRNVDQLLQRLIGEQKQA 573
            :::.|.:.|            .|..|    ::||..|||.|            ||||.
Worm   490 DDMMDNEAD------------DNHYF----RRRRGPLQLFV------------LLQRA------- 519

  Fly   574 ATQARISDWLEETQRLFGDDELPTTSAEAAAREQRRRDGVLLCRNRRTQEFKIVETPKSRITQRT 638
                             |::.|        ||.....|||   .|...:|.         ...|.
Worm   520 -----------------GEEHL--------ARMLEEHDGV---ENDLLEEL---------FNMRR 547

  Fly   639 RKRKLRQLIQTTKHRRATGRPRTTEMDEGSASSDTGASYDSDEEETSSGDNNNNNSNERESVRTD 703
            |.|                       :|.|...|:|          ..|:|.:.|.||.:::.:.
Worm   548 RFR-----------------------EESSDEDDSG----------DDGENGDENDNENDNIESS 579

  Fly   704 DDGDNSSTTS 713
            ....:||..|
Worm   580 SSNSDSSDAS 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42233	NP_651899.2	WD40	<45..404	CDD:225201	120/403 (30%)
		WD40 repeat	56..91	CDD:293791	10/54 (19%)
		WD40	90..402	CDD:295369	107/346 (31%)
		WD40 repeat	100..142	CDD:293791	21/42 (50%)
		WD40 repeat	147..183	CDD:293791	15/38 (39%)
		WD40 repeat	191..225	CDD:293791	6/33 (18%)
		WD40 repeat	232..270	CDD:293791	9/40 (23%)
		WD40 repeat	278..371	CDD:293791	26/116 (22%)
		WD40 repeat	377..401	CDD:293791	12/23 (52%)
R11D1.1	NP_506171.2	WD40	39..399	CDD:225201	114/383 (30%)
		WD40	58..395	CDD:295369	108/348 (31%)
		WD40 repeat	69..111	CDD:293791	20/41 (49%)
		WD40 repeat	118..152	CDD:293791	14/33 (42%)
		WD40 repeat	230..293	CDD:293791	10/62 (16%)
		WD40 repeat	306..343	CDD:293791	12/38 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158955
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	143	1.000	Inparanoid score	I3046
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270484at2759
OrthoFinder	1	1.000	-	-		FOG0008129
OrthoInspector	1	1.000	-	-		oto20446
orthoMCL	1	0.900	-	-		OOG6_107257
Panther	1	1.100	-	-	LDO	PTHR15574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3879
SonicParanoid	1	1.000	-	-		X6083
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.930