DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42233 and dcaf5

DIOPT Version :9

Sequence 1:	NP_651899.2	Gene:	CG42233 / 43754	FlyBaseID:	FBgn0250755	Length:	773	Species:	Drosophila melanogaster
Sequence 2:	XP_002935378.2	Gene:	dcaf5 / 100497059	XenbaseID:	XB-GENE-1002936	Length:	936	Species:	Xenopus tropicalis

Alignment Length:	824	Identity:	272/824 - (33%)
Similarity:	406/824 - (49%)	Gaps:	150/824 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 RERLSAAQNLYQRNLTGHYGCVNALEFS-SGGQFLASGGDDKRVLLWNIDRELVSKLGKPRSMNE 141
            |.||.|.:|||:::|.||||||||:||| :||..|.|||||:|||||::::.:.|| .||..:..
Frog    33 RRRLQACRNLYKKDLLGHYGCVNAIEFSNNGGNMLVSGGDDRRVLLWHLEQAIHSK-AKPIQLKG 96

  Fly   142 KHASNIFCLGFDTQNSYIFSGGNDDLVIQHDLETGKILNHFSHDGPVYGLSVDRISGHLLSVATE 206
            :|.||||||.|::.|:.:||||||:.||.||:|:|:.|:.|:|:..||||||..::.::.:.:::
Frog    97 EHHSNIFCLAFNSCNTRVFSGGNDEQVILHDVESGETLDVFAHEEAVYGLSVSPVNDNVFASSSD 161

  Fly   207 HGEILVYDLR-AGKSEPLAIAKFKTPFNAVEFHPLNGNFLATANAKRGAMLWDLRHHQQALCQYN 270
            .|.:|::|:| :.:.:|..:|.:.:.|::|.|:|:....|||||:|.|..|||:|....:|.:|.
Frog   162 DGRVLIWDIRESPQGDPFCLAHYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPHSSLLRYG 226

  Fly   271 YIPESPSCMSVRFNCNGTLLLTLHRRLPPILYSPGAPEPVATFYHDEYFNSCTMKSCTFAGPQDE 335
            ......|.||||||.:||.||.|.|||||:||...:..|:..|.:..||||||||||.|||.:|:
Frog   227 GNLSLQSAMSVRFNSSGTQLLALRRRLPPVLYDIHSRLPIFQFDNQGYFNSCTMKSCCFAGDRDQ 291

  Fly   336 LVVSGSDNFNMFIWRL-EGVDLDEKNQWMETTPVILAGHRSIVNQVRYNRERCLLASSGVEKIIK 399
            .::||||:||:::||: ...:.....:.:....:||.||||||||||:|.|..::.|||||||||
Frog   292 YILSGSDDFNLYMWRIPSSPEAGGAGRVVNGAFMILKGHRSIVNQVRFNPETYMICSSGVEKIIK 356

  Fly   400 LWSPFAQQGWEGSLT-QAEALPYCTRALYR---------ESSDHVSQDFSARSTDEDQVMLAFFD 454
            :|||:.|....|.|. |.|.   .:|.||.         .|...:|.|::.:|..||..|:||||
Frog   357 IWSPYRQPSCNGDLDGQVED---DSRCLYTHEEYIGLVLNSGSGLSHDYANQSVQEDPRMMAFFD 418

  Fly   455 TLVQHELESWSTVDNQNS---------SKSSTHTSTCSEAS---SPTEEPSDEEDQDPQTDRNQN 507
            :||:.|:|.||:..:.:|         |:.|.::.:.|..|   ||...|.:.::.....|..::
Frog   419 SLVRREIEGWSSDSDSDSTILQLHPGVSERSAYSDSVSSTSLPPSPVATPGESDEAATAGDSQRS 483

  Fly   508 EEN-------------------VQDQDIDT--------PNVSELSWQTYP-NRIFYLIAKKRRSL 544
            .|:                   .||:.:.|        .|.:|...:|.| :|......::.||.
Frog   484 AESPPTRSELSSHQLRMLALRKYQDKRLATMSNNTDSDDNATETEAETEPFSRPRSPSPEEERSS 548

  Fly   545 -----LQLAVRGTSRHPRNVDQLLQRLIGEQKQAATQARISDWLEETQRLFGDD--ELP------ 596
                 ..|..|..|...||..:..|::..|:|..|..       :.|..:.|:|  |.|
Frog   549 SSDEESNLNDRRASMRQRNALRHQQKIQREKKAKAKS-------QSTPSVVGEDVYEYPQITVDE 606

  Fly   597 -TTSAEAAAR-----EQRRRDGVLLCRNRRTQEFKIVETPK----------------SRITQRT- 638
             :||||::..     |..|:..  ||.:..:.|.||.:..|                |.:..|.
Frog   607 QSTSAESSPERRSPSEVERKSS--LCSDIDSVERKIYKAYKWLQYSYISYSKGKEGESSLNGRES 669

  Fly   639 ---------RKRKLRQLIQTTKHRRATGRPRTTEMDEGSASSDTGASYDSDEEETSSG------- 687
                     |...|..|::|......|.:...|...||..|.  ....||.:|..||.
Frog   670 EDGRPGTSGRSSVLPPLLETESSNETTSQESKTPSSEGLHSQ--SVHKDSSQENLSSSPGYHSGK 732

  Fly   688 ----DNNNNNSNERESVRTDDDGDNSSTTSLTSMEAQFSQAPSTSSSFLFHQLESN---NNSQHT 745
                ::..|:|::..||.:.     |.|..|....|.  :..:..|...|.|.||:   .||||.
Frog   733 PLWLEDLENSSHDTASVESP-----SETKKLNGASAH--KELTVCSEDYFSQCESSMTLKNSQHQ 790

  Fly   746 S---NQNHKALNGLIP-------DNC------NTESTASTSSSM 773
            .   ||...:.....|       |||      .||...:.:|.|
Frog   791 QQIINQQTPSSTKESPTWFKGSIDNCLGSGNSETEGEEADNSCM 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42233	NP_651899.2	WD40	<45..404	CDD:225201	157/328 (48%)
		WD40 repeat	56..91	CDD:293791	7/12 (58%)
		WD40	90..402	CDD:295369	148/314 (47%)
		WD40 repeat	100..142	CDD:293791	22/42 (52%)
		WD40 repeat	147..183	CDD:293791	19/35 (54%)
		WD40 repeat	191..225	CDD:293791	8/34 (24%)
		WD40 repeat	232..270	CDD:293791	16/37 (43%)
		WD40 repeat	278..371	CDD:293791	43/93 (46%)
		WD40 repeat	377..401	CDD:293791	16/23 (70%)
dcaf5	XP_002935378.2	WD40	47..359	CDD:392136	148/312 (47%)
		WD40 repeat	103..138	CDD:293791	18/34 (53%)
		WD40 repeat	143..185	CDD:293791	12/41 (29%)
		WD40 repeat	190..220	CDD:293791	14/29 (48%)
		WD40 repeat	227..270	CDD:293791	20/42 (48%)
		WD40 repeat	278..327	CDD:293791	18/48 (38%)
		WD40 repeat	334..358	CDD:293791	16/23 (70%)
		DMP1	<605..756	CDD:369294	33/159 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11643
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2133
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008129
OrthoInspector	1	1.000	-	-		oto103760
Panther	1	1.100	-	-	LDO	PTHR15574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6083
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060