DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir100a and Ir40a

DIOPT Version :9

Sequence 1:	NP_651898.2	Gene:	Ir100a / 43753	FlyBaseID:	FBgn0039879	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	728	Identity:	136/728 - (18%)
Similarity:	252/728 - (34%)	Gaps:	195/728 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LQLIMLALVGGTLGQANNTD--------HKQVLTSIV-KQLEGGLELHLRTSEDGGNDLVQFLMQ 60
            |.|..|||..|...:..|..        |:....|:| .|.|...: |:..:..|.|:.:..::.
  Fly    51 LALPSLALSDGVCQKERNVYLDDFLQRLHRSNYKSVVFSQTELFFQ-HIEENLQGANECISLILD 114

  Fly    61 EKSSIIISAKQEEVPSRAKIMRHHFFIFDGVHQMQEIRTSLFNTDGFYILALENNTIEDDVLLME 125
            |.:.::.|.....:..|..:    |..:.|.......|...|......::....
  Fly   115 EPNQLLNSLHDRHLGHRLSL----FIFYWGARWPPSSRVIRFREPLRVVVVTRP----------- 164

  Fly   126 FAADVWLQHGHSRIYYVQ---LSKKSVLLFNPF------LQRLVVVQDSKTYSRIYKDLEGYHLR 181
                   :....||||.|   .|...:.|.|.:      |||:.::   .|...:|.:.:|...|
  Fly   165 -------RKKAFRIYYNQARPCSDSQLQLVNWYDGDNLGLQRIPLL---PTALSVYANFKGRTFR 219

  Fly   182 IYIF-----------------DSVYSSVIGDGENKVLSVTGADAKLAKTVARQLNFTADFVWPDD 229
            :.:|                 |..::|:....:.||....|.|.:|...:::.:||...::....
  Fly   220 VPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTGGRDHRLLMLLSKHMNFRFKYIEAPG 284

  Fly   230 EFFG------GRLANGEYSGGVGRAHRGEVDIIFAGFFIKDY-----LTTHIQFSAAVYMDELCL 283
            ...|      |:.:|..::||:|....|:.|     ||:.|.     ....|:||.....|....
  Fly   285 RTQGSMRSEDGKDSNDSFTGGIGLLQSGQAD-----FFLGDVGLSWERRKAIEFSFFTLADSGAF 344

  Fly   284 YVKKAQRIPQSILPLFAVHMDVWLCFLLVGLLGALVWLILRAVNLILGIEGVPDGSRA----TRI 344
            .....:|:.:::..:.....|:|         ..|:..|:.:..:..||..:|...|.    :.:
  Fly   345 ATHAPRRLNEALAIMRPFKQDIW---------PHLILTIIFSGPIFYGIIALPYIWRRRWANSDV 400

  Fly   345 SYFGAARRIFVD-TWVIWVRVNVGRFPP------------------FHSERIFVASLC------- 383
            .:.|   .:::. |::..:...:.:..|                  :.:.|:|:...|
  Fly   401 EHLG---ELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGY 462

  Fly   384 ---LVSVIFGALLESSLATVY--------IRPLYYRDVNTLRELD----ESGQPIYIKHPAFKDD 433
               .:::::.......||.||        .||.....:|||:.|.    ..|..:|::..:...:
  Fly   463 RAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSSLE 527

  Fly   434 LFYGHNSEVYRRL--------------------DAKMMLVAEGEERLIEMVSKRGGFAGVTR--S 476
            :. .:.:|::|:|                    :|.:.|:|||.|....:..:...|..|.:  |
  Fly   528 ML-ENGTELFRQLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGS 591

  Fly   477 ASLQLSDIRYVMTKKVHKIPECPKNYHIAYVLPRPSPYLEEVNRIVLRLVAGGIVGLWTG----- 536
            .:.|||...|.....|.....|              |:|..:|.::::|...||:...|.
  Fly   592 NNFQLSQKLYTRYSAVAVQIGC--------------PFLGSLNNVLMQLFESGILDKMTAAEYAK 642

  Fly   537 -----EAKERAKWSIQ--------RFPEYLAELDVGRWKVLTLSDVQLAFYALTIGCLLSAIVCM 588
                 ||....|.|:|        |...|    |......|.|..:|.||.||.:|.|.:.::.:
  Fly   643 QYQEVEATRIYKGSVQAKNSEAYSRTESY----DSTVISPLNLRMLQGAFIALGVGSLAAGVILL 703

  Fly   589 AEILLGR--QRRL 599
            .||:..:  |.||
  Fly   704 LEIVFIKLDQARL 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir100a	NP_651898.2	Periplasmic_Binding_Protein_Type_2	210..>255	CDD:304360	10/50 (20%)
Ir100a	NP_651898.2	Lig_chan	<439..580	CDD:278489	40/180 (22%)
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	25/126 (20%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	21/107 (20%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	30/155 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42643
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100