Protein Alignment Acf and KAT2B

DIOPT Version :9

• Sequence 1: NP_536734.2
• Gene: Acf / 43751
• FlyBaseID: FBgn0027620
• Length: 1476
• Species: Drosophila melanogaster
• Sequence 2: NP_003875.3
• Gene: KAT2B / 8850
• HGNCID: 8638
• Length: 832
• Species: Homo sapiens
• Alignment Length: 1015
• Identity: 190/1015 - (18%)
• Similarity: 301/1015 - (29%)
• Gaps: 417/1015 - (41%)

  Fly   558 RQDLRALVVG--ENKR-----LAAVEINRKKLTQMHHLEVNGVEPEKREAL-----VEKLKKSIA 610
            |.||:.::|.  |:.|     |||         .:.||| |..|.|....|     ||.|...:
Human   122 RADLQQIIVSLTESCRSCSHALAA---------HVSHLE-NVSEEEMNRLLGIVLDVEYLFTCV- 175

  Fly   611 ELHAQSDQQHRKHELQMLKLHSQLFNFLVYLGMDRCYRKYYVLESMPGI--FVEHSPDSLDTCLE 673
                     |::.:....:::..||..|         ||..:....|.:  .:|..|......:|
Human   176 ---------HKEEDADTKQVYFYLFKLL---------RKSILQRGKPVVEGSLEKKPPFEKPSIE 222

  Fly   674 QPITNKSQIEIRQQSALPKNRKDLRVYLLKLYGDDEKKTKKKAKHSLENKENQEHRLNGSAEPMD 738
            |.:.|..|.:.   |.||...:...|.|.|::               .|:.|..|.
Human   223 QGVNNFVQYKF---SHLPAKERQTIVELAKMF---------------LNRINYWHL--------- 260

  Fly   739 VESDSPEAPTHFELLMCSGDKRSCIVHDSRNGQRQ---RW-AYIYKAEEIDELIKALNPNGLREY 799
                  |||:...|       ||  .:|..:|.::   || .|....:..|.|.:         |
Human   261 ------EAPSQRRL-------RS--PNDDISGYKENYTRWLCYCNVPQFCDSLPR---------Y 301

  Fly   800 ELLQEL--SVLRS--------LIEQHAKTCPVDLLSLENETM----RKKFMAAMESET---NRKY 847
            |..|..  ::|||        |:||..:  ..|.|.||..|:    ..||::.:|.|.   |...
Human   302 ETTQVFGRTLLRSVFTVMRRQLLEQARQ--EKDKLPLEKRTLILTHFPKFLSMLEEEVYSQNSPI 364

  Fly   848 GEANFGLPNGTDLNEVMRLHLVDRIIQFENDIYTGDLGRLKV----------------KDMEKWR 896
            .:.:|       |:...|               |..||...|                ..:|:..
Human   365 WDQDF-------LSASSR---------------TSQLGIQTVINPPPVAGTISYNSTSSSLEQPN 407

  Fly   897 SDLLGGNYDAQCKLQWGPGGKLEDEAGSDNESHETHEEDDGALLGKYARKP-------------- 947
            :    |:....||...|    ||...|...:..::|..::       |:||
Human   408 A----GSSSPACKASSG----LEANPGEKRKMTDSHVLEE-------AKKPRVMGDIPMELINEV 457

  Fly   948 ---YRDPGMYLAASADTKPLPDSDDEEDQHTNAVSIPIAVHNMASALLQVEQAIGKRFLKEPYGM 1009
               ..||...|....:......:.||..:......: |..|.:.::|   .|...|:.|....|:
Human   458 MSTITDPAAMLGPETNFLSAHSARDEAARLEERRGV-IEFHVVGNSL---NQKPNKKILMWLVGL 518

  Fly  1010 KK------------------WDPKQEALKLACDSRL------------HQWEVSLMESTSFAQV- 1043
            :.                  :|||.:.|.|..|.|:            ...|:.....||..||
Human   519 QNVFSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVK 583

  Fly  1044 ------FLHL---NILHDCIQWRRSTNKSLCKVCRRGSDPEKMLLCDECNAGTHMFCLKPKLRSV 1099
                  ..||   :|.||.:.:                    :...||
Human   584 GYGTHLMNHLKEYHIKHDILNF--------------------LTYADE----------------- 611

  Fly  1100 PPGNWYCNDCVKSLGLSNGQNEKDKKQATKKKRKFIVEEEDDEATDEEEEEKKDDDMTDEDAEHE 1164
                 |.....|..|.|        |:....|.|::...:|.|.
Human   612 -----YAIGYFKKQGFS--------KEIKIPKTKYVGYIKDYEG--------------------- 642

  Fly  1165 NEKHDEDVEDDESVTSTPSSSRVNGRILRRPRTRPTSRRLTSKEIEEHAQEDVDSGDVSDDASLT 1229
                           :|.....:|.||   |.|..:......|||.:...|
Human   643 ---------------ATLMGCELNPRI---PYTEFSVIIKKQKEIIKKLIE-------------- 675

  Fly  1230 AGEDTIEDESDEEKVCQ--KCFYDGGEIKCVQCRLFFHLECVHLKRPPRTDFVCKTCKPMPQRPR 1292
                  ..::...||..  .||.||  ::.:                           |:...|.
Human   676 ------RKQAQIRKVYPGLSCFKDG--VRQI---------------------------PIESIPG 705

  Fly  1293 RRHSNMNGDHDRDEEEPKAKRPRNSLRLSIDKTARPSNGNNNNNNNNSSVNNNNHRRSGRRTNEH 1357
            .|.:..     :...:.|:|.||:..:|
Human   706 IRETGW-----KPSGKEKSKEPRDPDQL------------------------------------- 728

  Fly  1358 MPLNSAALYDLLEQIMKHKAAWPFLRPVLTSEVPDYHQIIKTPMDLAKIKSKLNMGAYQLNEELL 1422
                .:.|..:|:|:..|::||||:.||..:|.|.|:::|:.||||..:..:|....|...:..:
Human   729 ----YSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFM 789

  Fly  1423 SDIQLVFRNCDLYNVEGNEIYDAGCQLERFVIDRCRDMQL 1462
            :|:|.||.||..||...:|.|.....||:|...:.::..|
Human   790 ADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGL 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503
		DDT	346..411	CDD:214726
		WHIM1	505..554	CDD:292246
		WHIM2	637..666	CDD:292247	5/30 (17%)
		WHIM3	775..813	CDD:292248	11/48 (23%)
		PHD_RSF1	1064..1109	CDD:277018	3/44 (7%)
		PHD	1244..1284	CDD:214584	5/41 (12%)
		Bromo_Acf1_like	1349..1463	CDD:99936	34/114 (30%)
KAT2B	NP_003875.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54
		PCAF_N	75..325	CDD:368925	61/282 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	395..436		8/48 (17%)
		COG5076	487..826	CDD:227408	92/526 (17%)
		Acetyl-CoA binding. /evidence=ECO:0000269|PubMed:10393169	574..576		0/1 (0%)
		Acetyl-CoA binding. /evidence=ECO:0000269|PubMed:10393169	581..587		2/5 (40%)
		Acetyl-CoA binding. /evidence=ECO:0000269|PubMed:10393169	612..615		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	706..725		5/23 (22%)
		Bromo_gcn5_like	727..826	CDD:99941	34/139 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158459
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740