DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acf and RSC4

DIOPT Version :9

Sequence 1:	NP_536734.2	Gene:	Acf / 43751	FlyBaseID:	FBgn0027620	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	NP_012933.4	Gene:	RSC4 / 853877	SGDID:	S000001716	Length:	625	Species:	Saccharomyces cerevisiae

Alignment Length:	705	Identity:	132/705 - (18%)
Similarity:	254/705 - (36%)	Gaps:	176/705 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 VQAKKNATYTVLGVKLDKNMP--EPLNGIYEDTDNLVYRLRPNKGDPSAELDLPFRQLRRSRMEF 189
            |:.:|.||......:..|.:|  .|.|  .|.|.::.|....|   |.:||.|.         ::
Yeast     3 VKKRKLATEAGGSDERPKYLPGKHPKN--QEKTPHVDYNAPLN---PKSELFLD---------DW 53

  Fly   190 NLENLSMFIKSNVSRVDGLLRPKPEAYKQYVTDPGVNFSTIFIGKMPR-YSPAKIKKPDGKKQST 253
            ::...:.||...   :|.|:....:.:|.::..|...|...:..|:.: .|..:||..|.:.:..
Yeast    54 HIPKFNRFISFT---LDVLIDKYKDIFKDFIKLPSRKFHPQYYYKIQQPMSINEIKSRDYEYEDG 115

  Fly   254 LNKYIVAGEATAAKSKAKAKSDAKSLAEELERVKREKEAKLIELEKQKA-----------EKKA- 306
            .:.:::..|......:|..:.|:..:...::.|      .|||.|..||           |.||
Yeast   116 PSNFLLDVELLTKNCQAYNEYDSLIVKNSMQVV------MLIEFEVLKAKNLKRNYLINSEVKAK 174

  Fly   307 ------QLIERVENECNLLL------QKTDD--------LERTDQKVLPRYRQIVTLLPEHLLGD 351
                  :|::..|.:.|..|      :..||        :|..|:..||.|.:||
Yeast   175 LLHYLNKLVDATEKKINQALLGASSPKNLDDKVKLSEPFMELVDKDELPEYYEIV---------- 229

  Fly   352 AFMMREFMHTYTGLLSGIEVFRQNLSFYEMTRALTAREIAGPLSDILLVLLGT-VFDLQKEEEEE 415
                    |:...|    .:.:|||...:.::      |...:.|:|||.... :|:      :.
Yeast   230 --------HSPMAL----SIVKQNLEIGQYSK------IYDFIIDMLLVFQNAHIFN------DP 270

  Fly   416 CAVTYLDRAAQTQEPYWSMAQAAKSHLYAKRHFS--FKVNE-----LPLDALTLSEVLRLHLLG- 472
            .|:.|.|  |.|...|:       ::|..|..|.  ..:||     |..|.......|.:...|
Yeast   271 SALIYKD--ATTLTNYF-------NYLIQKEFFPELQDLNERGEINLEFDKFEFENYLAIGGGGP 326

  Fly   473 --SGAF--------VNEKAERWRVMYRNGYSSKEDPGLELRLEHSHILRILKNHSVYQLKFKDIM 527
              :||.        :..::.|..::.:..|......||......|   .:.:::.:....||.::
Yeast   327 AAAGALAISALDNDIEPESNREDLIDQADYDFNHFEGLGNGYNRS---LLTEDYLLNPNNFKKLI 388

  Fly   528 LLIRCLMSQIMTYSGTINLIEERMEQTAKARQDLRALVVGENKRLAAVEINRKKLTQMHHLEVNG 592
            .....:.|::                              :|:|....:|.:....:..||::
Yeast   389 AKPETVQSEV------------------------------KNERSTTSDIEKTNSLESEHLKI-- 421

  Fly   593 VEPEKREALVEKLKKSIAELHAQSDQQHRKHEL-QML------KLHSQLFNFLVYLGMDRCYRKY 650
                .:..:::.::|.:..|..|...:::.::| |.:      .|:||....|  ||......:.
Yeast   422 ----PKYNVIKSMQKEMQSLSEQHTMEYKPYKLIQQIYIFSSKNLYSQATKPL--LGSRPSCNQN 480

  Fly   651 YVLESMPGIFVEHSPDSLDTCLEQPITNKSQIEIRQQSALPKNRKDLRVYLLKLYGDDEKKTKKK 715
            :|.....|..:..:.::....| ||:    |..:..||.|..:.||... ||.:..:..|.....
Yeast   481 WVEYIFNGNELSQNENAFSFML-QPM----QTFLTLQSHLTSSLKDTET-LLTINKEPVKSRTSN 539

  Fly   716 AKHSLENKENQEHRLNGSAEPMDVESDSPEAPTHFELLMCSGDKRSCI--VHDSR 768
            ...:|...:.||:.:.|:....|:|:.:.....:.:::....|||:.|  :.|.|
Yeast   540 VNSNLSQPQQQENDVIGNDTKQDIENLTIGGGNNNDIVGNDNDKRNNITEIFDIR 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503
		DDT	346..411	CDD:214726	11/65 (17%)
		WHIM1	505..554	CDD:292246	4/48 (8%)
		WHIM2	637..666	CDD:292247	5/28 (18%)
		WHIM3	775..813	CDD:292248
		PHD_RSF1	1064..1109	CDD:277018
		PHD	1244..1284	CDD:214584
		Bromo_Acf1_like	1349..1463	CDD:99936
RSC4	NP_012933.4	COG5076	40..423	CDD:227408	84/485 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900