DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acf and RSC1

DIOPT Version :9

Sequence 1:	NP_536734.2	Gene:	Acf / 43751	FlyBaseID:	FBgn0027620	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	NP_011570.1	Gene:	RSC1 / 852947	SGDID:	S000003288	Length:	928	Species:	Saccharomyces cerevisiae

Alignment Length:	1025	Identity:	177/1025 - (17%)
Similarity:	304/1025 - (29%)	Gaps:	373/1025 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   586 HHLEVNGVE--------PEKRE-----------ALVEKLKKSIAELHAQSDQQHRKHELQMLKLH 631
            |..:.||:|        |.|:|           ..:..|||.:.  |..|.|.......|:
Yeast    22 HLKDENGIEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRLP--HYTSPQDFVNDFAQI---- 80

  Fly   632 SQLFNFLVYLGMDRCYRKYYV-LES------------------------MPGIFVEH-SPDSLDT 670
              .:|.:.|...|....||.: |||                        :|.||.|. .|..|.:
Yeast    81 --PWNAMTYNAKDSVIYKYAILLESFIKGKIVHNIRKHYPEVTYPSLGRIPEIFAESMQPSDLSS 143

  Fly   671 CLEQPITNKSQIEIRQQSALPKNRKDLRVYLLKLYGDDEKKTKKKAKHSLENKENQEHRLNGSAE 735
               .||..:   |..:::.|   ..::::...||   |...|::|       ..||::|:.
Yeast   144 ---NPINTQ---ENDEKAGL---NPEMKMAFAKL---DSSITERK-------PTNQDYRMQ---- 185

  Fly   736 PMDVESDSPEAPTHFELL----MCS-----GDKRSCIVHDSRNGQRQR-----WAYIYKAEEIDE 786
                :.:||..|||...:    :.|     ........|...:.:|.|     ..|:.:.:.|
Yeast   186 ----QKNSPAFPTHSASITPQPLASPTPVVNYANITSAHPKTHVRRGRPPVIDLPYVLRIKNI-- 244

  Fly   787 LIKALNPNGLREYELLQELSVLRSLIEQHAKT---C-------------------PVDLLSLENE 829
                              |.::|..::|:.||   |                   |:.|:.:..:
Yeast   245 ------------------LKMMRREVDQNNKTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKK 291

  Fly   830 TMRKKFMAAMESETNRKYGEANFGLPNGTDLNEVMRLHLVD----RIIQFE-------------- 876
            ...:|:......|.:.:....||.|....|.:.::|..|::    |:::.|
Yeast   292 VKSRKYRNFHTFEEDFQLMLTNFKLYYSQDQSNIIRAQLLEKNFNRLVRIELSKPDEDYLPEGEL 356

  Fly   877 -------------------------NDI---YTGDLGRL-KVKDMEKW--------------RSD 898
                                     |||   ..|.:.|| ...|..||              |.|
Yeast   357 RYPLDDVEINDEKYQIGDWVLLHNPNDINKPIVGQIFRLWSTTDGNKWLNACWYFRPEQTVHRVD 421

  Fly   899 LL--------GGNY--------DAQC------KLQWG-PGGKLEDEAGSDNESHETHEEDDGALL 940
            .|        .|.|        ..:|      :.|.| |..|:.   |........:.|.|
Yeast   422 RLFYKNEVMKTGQYRDHPIQDIKGKCYVIHFTRFQRGDPSTKVN---GPQFVCEFRYNESD---- 479

  Fly   941 GKYARKPYRDPGMYLAASADTKPLPDSDDEEDQHTNAVSIPIAVHNMASALLQVEQAIGKRFLKE 1005
                 |.:.....:.|.      ||:...::|:.|    ||:.               |::|.|.
Yeast   480 -----KVFNKIRTWKAC------LPEELRDQDEPT----IPVN---------------GRKFFKY 514

  Fly  1006 PYGMKKWDPKQEALKLACDSRLHQWEVSLMESTSFAQVFLHLNILHDCIQWRRSTNKSLCKVCRR 1070
            |..:....|....|.   |......|.:.........|:|...:..|.: ...||:....:...|
Yeast   515 PSPIADLLPANATLN---DKVPEPTEGAPTAPPLVGAVYLGPKLERDDL-GEYSTSDDCPRYIIR 575

  Fly  1071 GSDPEK---------MLLCDECNAGT----------HMFCLKPKLRSVPPGNWYC---------- 1106
            .:||.:         .::.|.....:          .:..|| :.:|:|..|:..
Yeast   576 PNDPPEEGKIDYETGTIITDTLTTSSMPRVNSSSTIRLPTLK-QTKSIPSSNFRSSSNTPLLHQN 639

  Fly  1107 -NDCVKSLGLSNGQNEKDKKQATKKKRKF----IVEEEDDEATDEEEEEKKDDDMTDEDAEHENE 1166
             |.....|.|.|..|......:.....||    ::|:   .:..:....||...::....:....
Yeast   640 FNQTSNFLKLENMNNSSHNLLSHPSVPKFQSPSLLEQ---SSRSKYHSAKKQTQLSSTAPKKPAS 701

  Fly  1167 K-------------HDEDVEDDESVTSTPSSSRVNGRILRRPRTRPTSRRLTSKEIEEHAQEDVD 1218
            |             |......:..|...|.:..|...:.:..||..::.|.:...: ::||   :
Yeast   702 KSFTLSSMINTLTAHTSKYNFNHIVIEAPGAFVVPVPMEKNIRTIQSTERFSRSNL-KNAQ---N 762

  Fly  1219 SGDVSDDASLTAGEDTIEDESDEEKVCQKCFYDGGEIKCVQCRLFFHLECVHLKRPPRTDFVCKT 1283
            .|:.:.:...||.|..|..:....|:.::....|.:                |.|.|...:.||.
Yeast   763 LGNTAINDINTANEQIIWFKGPGVKITERVIDSGND----------------LVRVPLNRWFCKN 811

  Fly  1284 CKPMPQRPRRRHSNMNGDHDRDEEEP----------KAKRPRNSLRLSIDKTARPSNGNNNNNNN 1338
                    :||..:.. |.:.|..||          ....|..||.|.:|....||:.|::|..:
Yeast   812 --------KRRKLDYE-DIEEDVMEPPNDFSEDMIANIFNPPPSLNLDMDLNLSPSSNNSSNFMD 867

  Fly  1339 NSSV----------------NNNNHRRSGRRTNEHMP------LNSAALY 1366
            .|::                .:.|.........|.:|      |||:|.|
Yeast   868 LSTIASGDNDGKECDTAEESEDENEDTEDEHEIEDIPTTSAFGLNSSAEY 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503
		DDT	346..411	CDD:214726
		WHIM1	505..554	CDD:292246
		WHIM2	637..666	CDD:292247	11/54 (20%)
		WHIM3	775..813	CDD:292248	4/37 (11%)
		PHD_RSF1	1064..1109	CDD:277018	10/74 (14%)
		PHD	1244..1284	CDD:214584	6/39 (15%)
		Bromo_Acf1_like	1349..1463	CDD:99936	7/24 (29%)
RSC1	NP_011570.1	Bromo_Rsc1_2_I	8..113	CDD:99952	22/98 (22%)
RSC1	NP_011570.1	COG5076	115..463	CDD:227408	65/394 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900