DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acf and BDF1

DIOPT Version :9

Sequence 1:	NP_536734.2	Gene:	Acf / 43751	FlyBaseID:	FBgn0027620	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	NP_013503.1	Gene:	BDF1 / 851115	SGDID:	S000004391	Length:	686	Species:	Saccharomyces cerevisiae

Alignment Length:	471	Identity:	100/471 - (21%)
Similarity:	159/471 - (33%)	Gaps:	157/471 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1073 DPEKMLLCDECNAGTHMFCLKPK-----LRSVPPGNWYCNDCVKSLGL-SNGQN--------EKD 1123
            ||...|..:|..|...:...|.:     |.|.|.|  ...:.::...| :||:|        .:|
Yeast    34 DPSNGLAEEENPANNQLHLKKARLDGDALTSSPAG--LAENGIEGATLAANGENGYNATGSGAED 96

  Fly  1124 KKQATKKKRKFIVEEEDDEATDEEEEEKKDDDMTDEDAEHENEKHDEDVEDDESVTSTPSSSRVN 1188
            ::|..||       ||..:.|.:|:.:             ||.|.:..:|    |...|:.:
Yeast    97 EQQGLKK-------EEGGQGTKQEDLD-------------ENSKQELPME----VPKEPAPA--- 134

  Fly  1189 GRILRRPRTRPTSRRLTSKEIEEHAQ--------------------EDVD--------------- 1218
                  |...|....|....|.:|.|                    :.||
Yeast   135 ------PPPEPDMNNLPQNPIPKHQQKHALLAIKAVKRLKDARPFLQPVDPVKLDIPFYFNYIKR 193

  Fly  1219 SGDVSD-DASLTAGEDTIEDESDEE---KVCQKCFYDGGE------IKCVQCRLFFHLECVHLKR 1273
            ..|:|. :..|..|...:.::..|:   .|.....::|..      .:.:|.....|:    |..
Yeast   194 PMDLSTIERKLNVGAYEVPEQITEDFNLMVNNSIKFNGPNAGISQMARNIQASFEKHM----LNM 254

  Fly  1274 PPRTDFVCKTCKPMPQRPR------------RRHSNMNGDHDRDEEEPKAK--RPRNSLRLSIDK 1324
            |      .|...|:..:.|            ||....||...|....||:|  .|..|
Yeast   255 P------AKDAPPVIAKGRRSSAQEDAPIVIRRAQTHNGRPKRTIHPPKSKDIYPYES------- 306

  Fly  1325 TARPSNGNNNNNNNNSSVNNNNHRRSGRRTNEHMPLNSAALYDLLEQIMKHKA-AWPFLRPV--L 1386
             .:|.:                     :|..:.|....:.|.:|:.:  ||.: .:|||.||  :
Yeast   307 -KKPKS---------------------KRLQQAMKFCQSVLKELMAK--KHASYNYPFLEPVDPV 347

  Fly  1387 TSEVPDYHQIIKTPMDLAKIKSKLNMGAYQLNEELLSDIQLVFRNCDLYNVEGNEIYDAGCQLER 1451
            :..:|.|...:|.||||..|..|||...||..|:...|::|||:||..:|.:|..:...|.:||.
Yeast   348 SMNLPTYFDYVKEPMDLGTIAKKLNDWQYQTMEDFERDVRLVFKNCYTFNPDGTIVNMMGHRLEE 412

  Fly  1452 FVIDRCRDMQLPFRPS 1467
            ....:..|     ||:
Yeast   413 VFNSKWAD-----RPN 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503
		DDT	346..411	CDD:214726
		WHIM1	505..554	CDD:292246
		WHIM2	637..666	CDD:292247
		WHIM3	775..813	CDD:292248
		PHD_RSF1	1064..1109	CDD:277018	10/40 (25%)
		PHD	1244..1284	CDD:214584	7/45 (16%)
		Bromo_Acf1_like	1349..1463	CDD:99936	37/116 (32%)
BDF1	NP_013503.1	COG5076	1..373	CDD:227408	82/414 (20%)
		Bromodomain	<339..417	CDD:413371	30/77 (39%)
		PTZ00108	<386..647	CDD:240271	13/43 (30%)
		BET	527..589	CDD:407211
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345968
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740