Protein Alignment Acf and ep300b

DIOPT Version :9

• Sequence 1: NP_536734.2
• Gene: Acf / 43751
• FlyBaseID: FBgn0027620
• Length: 1476
• Species: Drosophila melanogaster
• Sequence 2: XP_009297682.1
• Gene: ep300b / 565612
• ZFINID: ZDB-GENE-080403-15
• Length: 2646
• Species: Danio rerio
• Alignment Length: 1058
• Identity: 201/1058 - (18%)
• Similarity: 328/1058 - (31%)
• Gaps: 382/1058 - (36%)

  Fly   594 EPEKREALVEKLKKSIAELHAQSDQQHRKHELQMLKLHSQLFNFLVYLGMDRCYRKYYVLESM-- 656
            :||||:.:.::|   :..|||     |:.|..:......:..|      :..|.....||..|
Zfish   302 DPEKRKLIQQQL---VLLLHA-----HKCHRREQANGEVRQCN------LPHCRTMKNVLNHMTH 352

  Fly   657 ----PGIFVEHSPDSLDTCLEQPITNKSQIEIRQQSALPKN--RKDLRVYL-LKLYGDDEKKTKK 714
                ....|.|...|                 ||..:..||  |.|..|.| ||..||
Zfish   353 CQAGKSCQVAHCASS-----------------RQIISHWKNCTRHDCPVCLPLKSAGD------- 393

  Fly   715 KAKHSLENKENQEHRLNGSAEPM------DVESDSPEAPTHFELLMCSGDKRSCIVHDSRNGQRQ 773
                    |.||:..|.|:...|      .:....|.||.
Zfish   394 --------KRNQQSLLGGAGMAMGGPLGGSLPGGQPSAPN------------------------- 425

  Fly   774 RWAYIYKAEEIDELIKALNPNGL-REYELL-------------QELSV-----LRSL-------- 811
                |....:||       |:.: |.|..|             |:.||     :|||
Zfish   426 ----INPPSQID-------PSSIERAYAALGLTYQGNQASNQNQQTSVPGQPGMRSLNNMAGGNS 479

  Fly   812 -----------IEQHAKTCPVDLLSLENETMRKKFMAAMESETNRKYGEANFGL------PNG-- 857
                       ..||....|        :.|..:.|.| :|..|...|..|.|.      |:.
Zfish   480 MGVNGGVGAPMSNQHPGMLP--------DGMLHRNMTA-QSLMNDSSGVGNMGSAATATPPSAGM 535

  Fly   858 -----TDLNEVMRLHLVDRIIQFENDIY-TGDLGRLKVKDMEK---WRSDLLGGNYD-AQCKLQW 912
                 .|:.:.:|.|||.:::|   .|: |.|...||.:.||.   :...:.|..|: |..:.::
Zfish   536 RKSWHEDITQDLRNHLVHKLVQ---AIFPTPDPAALKDRRMENLVAYARKVEGDMYESANSRAEY 597

  Fly   913 -----GPGGKLEDEAGSDNESHETH-EEDDGALLGKYARKPYRDPGMYLAASADTKPLPDSDDEE 971
                 ....|::.|.   .|...|. ::.||         |:.||.:..|    |.|
Zfish   598 YHLLAEKIYKIQKEL---EEKRRTRLQKQDG---------PHSDPSLVQA----TGP-------- 638

  Fly   972 DQHTNAVSIPIAVHNMASALLQVEQAIGKRFLKEPYGMKKWDPKQEALKLACDSRLHQWEVSLME 1036
            .|..|.:..|..:.:..:.:.|..| :|   :::|.|.:...|      |...:.|:|  :|:..
Zfish   639 SQMVNRMQNPAGMPHSLNGMNQFGQ-VG---MQQPMGQRATPP------LPMGANLNQ--MSMQG 691

  Fly  1037 STSFAQVFLHLNI--LHDCIQWRRSTNK---------SLCKVCRRGSDPEKMLLCDEC------- 1083
            :...||.    |:  |.:.....:.|..         .|.:...:|:.|:..:.....
Zfish   692 TPRMAQP----NVPQLQNQYMQNQFTGTGAGLGQGAVGLNQPAGQGAMPQNQMPTPPSLSVHSPV 752

  Fly  1084 ----------------------------NAGTHMFCLKPKLR-----------------SVP--- 1100
                                        ..|.|..|  |.||                 ..|
Zfish   753 AQSQSSVPVSGAAAGPQGPPSNHPPPAPQPGLHTHC--PPLRQNSPSPARSLTPTPAPHQTPPQL 815

  Fly  1101 PGNW----YCNDCVKSLGLSNGQNEKDKKQATKKKRKFIVEEEDDEATDEEEEEKKDDDMTDEDA 1161
            |||.    :..:...::.....|.....:....:|...:.::..........:......:..::|
Zfish   816 PGNQTPQPHTPNSSTTMAPPASQLPPMAQGVASEKSSQLQQQSHGGGATGGPQTGLASSVPSQNA 880

  Fly  1162 E------HE--NEKHDEDVEDDESVTSTPSSSRVNGRILRRPRTRPTSRRLTSK-EIEEHAQEDV 1217
            .      |.  ::|....|:...|..::.||:..:.::.....|.|    |.|| |:::..:|:.
Zfish   881 HGLCTHPHSPLSQKSSATVDGQASTPASVSSADPSSQLTSSEPTAP----LDSKTEVKQQDEEEE 941

  Fly  1218 DSGDVSDDASLTAGEDTIEDESDEEKVCQKCFYDGGEIKCVQCRLFFHLECVHLKRPPRTDFVCK 1282
            :..:..|.||........|.:|:|:.          |||               |..|..| .||
Zfish   942 NENETEDKASGKMAAMQTEIKSEEKP----------EIK---------------KEEPAGD-ECK 980

  Fly  1283 TCKPMPQRPRRRHSNMNGDHDRDEE---EPKAKRPRNSLRLSIDKTARPSNGNNNNNNNNSSVNN 1344
            | :||         ..:...|:..|   |||.:....:                     ||:..|
Zfish   981 T-EPM---------ETSTAEDKKPEVKTEPKEEEVAGA---------------------NSTPAN 1014

  Fly  1345 NNHRRSGRRTNEHMPLNSAALYDLLEQIMKHKAAWPFLRPV-----------LTSEVP--DYHQI 1396
            ...::...:.:|   |..|.:..|.....:...:.||.:||           .||...  ||..|
Zfish  1015 TQSKKKEFKPDE---LRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPVRIRTSNKTNLDYFDI 1076

  Fly  1397 IKTPMDLAKIKSKLNMGAYQLNEELLSDIQLVFRNCDLYNVEGNEIYDAGCQLERFV-------- 1453
            :|.|:||:.||.||:.|.||...:.:.|:.|:|.|..|||.:.:.:|....:|....
Zfish  1077 VKNPIDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKYCSKLAEVFEQEIDPVM 1141

  Fly  1454 --IDRCRDMQLPFRPSDM 1469
              :..|...:|.|.|..:
Zfish  1142 QELGYCCGRKLEFSPQTL 1159

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503
		DDT	346..411	CDD:214726
		WHIM1	505..554	CDD:292246
		WHIM2	637..666	CDD:292247	6/34 (18%)
		WHIM3	775..813	CDD:292248	13/75 (17%)
		PHD_RSF1	1064..1109	CDD:277018	13/103 (13%)
		PHD	1244..1284	CDD:214584	8/39 (21%)
		Bromo_Acf1_like	1349..1463	CDD:99936	34/136 (25%)
ep300b	XP_009297682.1	zf-TAZ	318..385	CDD:280324	18/94 (19%)
		KIX	534..614	CDD:280354	18/85 (21%)
		Bromo_cbp_like	1024..1142	CDD:99927	33/120 (28%)
		RING_CBP-p300	1154..1236	CDD:276805	2/6 (33%)
		PHD_SF	1237..1271	CDD:304600
		HAT_KAT11	1300..1607	CDD:285432
		ZZ_CBP	1663..1703	CDD:239077
		ZnF_TAZ	1724..1802	CDD:214717
		Creb_binding	<2164..2231	CDD:286163

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900