DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Acf and PBRM1

DIOPT Version :9

Sequence 1:	NP_536734.2	Gene:	Acf / 43751	FlyBaseID:	FBgn0027620	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	XP_016862214.1	Gene:	PBRM1 / 55193	HGNCID:	30064	Length:	1734	Species:	Homo sapiens

Alignment Length:	804	Identity:	159/804 - (19%)
Similarity:	274/804 - (34%)	Gaps:	219/804 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   777 YIYKAEEIDELIKALNPNGLREYELLQELSVLRSLIEQHAKT------------CPV-DL-LSLE 827
            |...::.|| |:|......:.||:.:..|:....|:..:||:            |.: || |...
Human   106 YEVVSQPID-LMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTR 169

  Fly   828 NETMRKKFMAAMESETNRKYGEANFGL-------------PNGTDLNEVMRLHLVDRIIQFENDI 879
            ||.::|   ...:.|.:.:.|:.|.|.             .:...|.|::. .|::.|:     :
Human   170 NEFVQK---GEADDEDDDEDGQDNQGTVTEGKVLFSPHYQSSPAYLKEILE-QLLEAIV-----V 225

  Fly   880 YTGDLGRLKVKDMEKWRSDLLGGNYDAQCKLQWGP------GGKLEDEAGSDNESHETHEEDDGA 938
            .|...|||..:..:|..|.:...:|.|..|   .|      ..::::  ||....|...::.|
Human   226 ATNPSGRLISELFQKLPSKVQYPDYYAIIK---EPIDLKTIAQRIQN--GSYKSIHAMAKDID-- 283

  Fly   939 LLGKYARKPYRDPGMYLAASADT-KPLPDSDDEEDQHTNAVSIPIAVH---NMASALL------- 992
            ||.|.| |.|.:||..:...|:: |.:......|.:|.......:.:.   |:|:|.|
Human   284 LLAKNA-KTYNEPGSQVFKDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSK 347

  Fly   993 --------------QVEQAI-GKRFLKEPYGMKKWDPKQEALKLACDSRLHQWEVSLMESTSFAQ 1042
                          :.::|: |.|.......::.....:|...||. :|..:.|......|||..
Human   348 GSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAALAA-ARYEEGESEAESITSFMD 411

  Fly  1043 VFLHLNILHDCIQWRRSTNKSLCKVCRRGSD----------PEKMLLCD---ECNAGTHMFCLKP 1094
            |......|:|.:           :.||....          |.|....|   :......:..::.
Human   412 VSNPFYQLYDTV-----------RSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRT 465

  Fly  1095 KLRSVPPGNWYCNDCVKSLGLSNGQNEKDKKQATKK---KRKFIVEEEDDEATDEEEEEKKDDDM 1156
            ||::.........:|..:|...|.:.......|..|   |.:.:::.:..|....::.|..|..:
Human   466 KLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMI 530

  Fly  1157 TDEDAEHENEKHDEDVEDDESVTSTPSSSRVNGR---------ILRRPRTRPTSRRLTS------ 1206
            :...::..:.|...:..|.|.:.....||:.|.|         ::...|...:.|||..
Human   531 SSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKP 595

  Fly  1207 ------------------KEIEEHAQEDVDSGD--VSDDASL---------TAGEDTIEDESDEE 1242
                              |.||.:.:.|..:|:  :.:|..|         ..|.....|....|
Human   596 SKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE 660

  Fly  1243 KVCQKCFYDGGEIKCVQCRLFFHLECVHLKRPPRTDFVCKTCKPMPQRPRRRHSNMNGDHDRDEE 1307
            |:.::                        ||        |...|:|.             |.|..
Human   661 KLLKE------------------------KR--------KELGPLPD-------------DDDMA 680

  Fly  1308 EPKAKRPRNSLRLSIDKTARPSNGNNNNNNNNSSVNNNNHRRSGRRTNEHMPLNSAALYDLLEQI 1372
            .||.|..|.| .:|..|:...:......|....:|.|...:| |||               |..|
Human   681 SPKLKLSRKS-GISPKKSKYMTPMQQKLNEVYEAVKNYTDKR-GRR---------------LSAI 728

  Fly  1373 MKHKAAWPFLRPVLTSEVPDYHQIIKTPMDLAKIKSKLNMGAYQLNEELLSDIQLVFRNCDLYNV 1437
                    |||....||:|||:..||.|||:.||:|.:....||..:.::.|..::|.|...||.
Human   729 --------FLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNE 785

  Fly  1438 EGNEIYDAGCQLERFVIDRCRDMQ 1461
            ..:.||.....|.:.:::..||::
Human   786 PESLIYKDALVLHKVLLETRRDLE 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503
		DDT	346..411	CDD:214726
		WHIM1	505..554	CDD:292246
		WHIM2	637..666	CDD:292247
		WHIM3	775..813	CDD:292248	9/35 (26%)
		PHD_RSF1	1064..1109	CDD:277018	7/57 (12%)
		PHD	1244..1284	CDD:214584	3/39 (8%)
		Bromo_Acf1_like	1349..1463	CDD:99936	34/113 (30%)
PBRM1	XP_016862214.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900