DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acf and nej

DIOPT Version :9

Sequence 1:	NP_536734.2	Gene:	Acf / 43751	FlyBaseID:	FBgn0027620	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster

Alignment Length:	862	Identity:	150/862 - (17%)
Similarity:	253/862 - (29%)	Gaps:	365/862 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   827 ENETMRKKFM-AAMESETNRKYGEANFGLPNGTDLNEVMRLHLVDRIIQFENDIYTGD--LGRLK 888
            :::.::|:|| .:.....:....:.:.|...|.::|.       |.....:.:|.|.|  .|.:|
  Fly  1568 QDDDIKKEFMDDSCGGNNDSSQMDCSTGGGKGKNVNN-------DGTSMIKMEIKTEDGLDGEVK 1625

  Fly   889 VKDMEKWRSDLLGGNYDAQCKLQWGPGGKLEDEAGSDNESHETHEEDDGALLGKYARKPYRDPGM 953
            :| .|....|..||:...:   ..|.||......|..:..:..|  |.||..|....||
  Fly  1626 IK-TEAMDVDEAGGSTAGE---HHGEGGGGSGVGGGKDNINGAH--DGGATGGAVDIKP------ 1678

  Fly   954 YLAASADTKPL------PDSDDEEDQ-HTNAVSIPIAVHNMASALLQVE------------QAIG 999
                ..:||||      |::.|::.: ..|...:..|:......|.:.|            ||:|
  Fly  1679 ----KTETKPLVPEPLAPNAGDKKKKCQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALG 1739

  Fly  1000 ----KRFLKEPYGM---------------------------KKW--------------------- 1012
                ...:|:|..:                           ..|
  Fly  1740 IPDYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFE 1804

  Fly  1013 ---DPKQEALKLAC-----------------------DSRLHQWEVSLMESTSFAQVFLHLNILH 1051
               ||..:||...|                       |::.:.::.||.|
  Fly  1805 AEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNSLKE--------------- 1854

  Fly  1052 DCIQWRRSTNK-SLCKVC---------RRGSDP----------------------EKMLLCDECN 1084
                :..::|: :.|:.|         ..|.||                      |..:.|.||.
  Fly  1855 ----YGVASNRYTYCQKCFNDIQGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLELEPFVNCQECG 1915

  Fly  1085 AGTHMFCLKPKLRSVPPGNWYCNDCVKSLGLSNGQNEKDKKQATKKKRKFIVEEEDDEATDEEEE 1149
            ...|..|:. .|.|:.||.:.|::|:|            ||.:.:|:.||..:...........|
  Fly  1916 RKQHQICVL-WLDSIWPGGFVCDNCLK------------KKNSKRKENKFNAKRLPTTKLGVYIE 1967

  Fly  1150 EKKDDDMTDEDAEHENEKHDEDV-EDDESVTSTPSSSR---VNGRILRRPRTRPTSRRLTSKEIE 1210
            .:.::.:..::| ...|.|...| ..|:.|...|...|   ..|.::.....|       :|.:
  Fly  1968 TRVNNFLKKKEA-GAGEVHIRVVSSSDKCVEVKPGMRRRFVEQGEMMNEFPYR-------AKAL- 2023

  Fly  1211 EHAQEDVDSGDVSDDASLTAGEDTIEDESDEEKVCQKCFYD------GGEIKCVQCRLFF--HLE 1267
             .|.|:||..||                         ||:.      |.|......|..:  :|:
  Fly  2024 -FAFEEVDGIDV-------------------------CFFGMHVQEYGSECPAPNTRRVYIAYLD 2062

  Fly  1268 CVHLKRPP--RT-----------DFV------------CKTCK---------------PMPQRPR 1292
            .||..||.  ||           |:|            |...:               |.|:|.:
  Fly  2063 SVHFFRPRQYRTAVYHEILLGYMDYVKQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQ 2127

  Fly  1293 RRHSNM----------------------------------NGDH------------DRDEEEPK- 1310
            ..:..|                                  .||.            |::|||.:
  Fly  2128 EWYKKMLDKGMIERIIQDYKDILKQAMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRK 2192

  Fly  1311 ----AKRPRNSLRLSIDKTARPSNGNNNNNNNNSSVNNNN--HRRSGRRTNEHMPLN--SAALYD 1367
                |:....:...||::.....:|...........|.:.  .|::.:::|||...|  |..:|.
  Fly  2193 QAEAAEAAAAANLFSIEENEVSGDGKKKGQKKAKKSNKSKAAQRKNSKKSNEHQSGNDLSTKIYA 2257

  Fly  1368 LLEQIMKHKAAWPFLR-----------------PVLTSEVPDYHQIIKTPMDLAKIK-------- 1407
            .:|   |||..:..:|                 |:||.::.|......|   ||:.|
  Fly  2258 TME---KHKEVFFVIRLHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLT---LARDKHFEFSSLR 2316

  Fly  1408 ----SKLNMGAYQLNEE 1420
                |.|:| .|:|:.:
  Fly  2317 RAQFSTLSM-LYELHNQ 2332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503
		DDT	346..411	CDD:214726
		WHIM1	505..554	CDD:292246
		WHIM2	637..666	CDD:292247
		WHIM3	775..813	CDD:292248
		PHD_RSF1	1064..1109	CDD:277018	16/75 (21%)
		PHD	1244..1284	CDD:214584	15/72 (21%)
		Bromo_Acf1_like	1349..1463	CDD:99936	24/103 (23%)
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354
		Bromo_cbp_like	1705..1812	CDD:99927	11/106 (10%)
		RING_CBP-p300	1824..1906	CDD:276805	10/100 (10%)
		PHD_CBP_p300	1908..1939	CDD:277032	10/31 (32%)
		HAT_KAT11	1970..2283	CDD:285432	59/350 (17%)
		ZZ_CBP	2339..2379	CDD:239077
		ZnF_TAZ	2404..2476	CDD:214717
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900