DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Acf and Cecr2

DIOPT Version :9

Sequence 1:	NP_536734.2	Gene:	Acf / 43751	FlyBaseID:	FBgn0027620	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	NP_001355635.1	Gene:	Cecr2 / 330409	MGIID:	1923799	Length:	1453	Species:	Mus musculus

Alignment Length:	585	Identity:	130/585 - (22%)
Similarity:	215/585 - (36%)	Gaps:	167/585 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   964 LPDSDDEEDQ---HTNAVSIPIAVHNMASALLQ----------------VEQAIGKRFLKEPYGM 1009
            |||.:.||.:   |.:.|..   :.::.:.|||                :|..|..|
Mouse    36 LPDFEIEELEAALHRDDVEF---ISDLIACLLQGCYQRRDITPQTFHSYLEDIINYR-------- 89

  Fly  1010 KKWDPKQEALKLACDSRLHQWEVSLMESTSFAQVFL--HLNILHDCIQWRRSTNK--SLCKVCRR 1070
              |:             |.:.:.:.:...||..:.|  .:.|||....:|...:.  .|.|
Mouse    90 --WE-------------LEEGKPNPLREASFQDLPLRTRVEILHRLCDYRLDADDVFDLLK---- 135

  Fly  1071 GSDPEKMLL--CDECNA--------GTHMFCLKPKLRSVPPGNW-YCNDCVKSLGLSNGQNEKDK 1124
            |.|.:.:.:  ..|.|:        ||.|:...| ::....|.. .|.:..:...:||...:..|
Mouse   136 GLDADSLRVEPLGEDNSGALYWYFYGTRMYKEDP-VQGRSNGELSLCRESERQKNVSNVPGKTGK 199

  Fly  1125 KQATKKKRKFIVEEEDDEATDEEEEEKKDDDM-------------------TDEDAEHENEKHDE 1170
            ::....|||.:  :|:..:::::||.....|:                   |:|:.....|...|
Mouse   200 RRGRPPKRKKL--QEEIISSEKQEENSLTSDLQTRNGSRGPGQGTWWLLCQTEEEWRQVTESFRE 262

  Fly  1171 DVEDDE-------SVTSTPSSSRVNGRILRRP-RTRPTSRRLTSKEIEEHAQEDVDSGDVSDDAS 1227
            .....|       |....|....:..:..:|| ||:|   .|..:.:.:|.  .:.|..:.:...
Mouse   263 RTSLRERQLYKLLSEDFLPEICNMIAQKGKRPQRTKP---ELQHRFMSDHL--SIKSIKLEETPM 322

  Fly  1228 LTAGEDTIEDESDEEK----VCQKCFYDGGEIKCVQCRLFFHLECVHLKRPPRTDFVCKTCKPMP 1288
            ||..|.....|.:||:    ..||                                  |..:.|.
Mouse   323 LTKIEKQKRREEEEERQLLLAVQK----------------------------------KEQEQML 353

  Fly  1289 QRPRRRHSNMNGDHDRDEEEPKA---KRPRNSLR------LSIDKTARPSNGNNNNNNNNSSVNN 1344
            :..|:|..         ||:.||   :..|..||      |:..|...|         ..|.::.
Mouse   354 KEERKREM---------EEKVKAVEDRAKRRKLREERAWLLAQGKELPP---------ELSHLDL 400

  Fly  1345 NNHRRSGRRTNEHMPLNS--AALYDLLEQIMKHKAAWPFLRPVLTSEVPDYHQIIKTPMDLAKIK 1407
            |:..|.|::|.:...|:.  .|:|.:|:.:..||.:||||.||..|..|:|:||||.|||::.::
Mouse   401 NSPMREGKKTKDLFELDDDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKIPMDISSME 465

  Fly  1408 SKLNMGAYQLNEELLSDIQLVFRNCDLYNVEGNEIYDAGCQLERFVIDRCRDMQLPFRPSDMNGE 1472
            .|||.|.|...||.::|::.:||||..||.:.:|.......||| ...|......|....|.:.|
Mouse   466 KKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKMSDNLER-CFHRAMTKHFPGEDGDTDEE 529

Fly 1473 1472
Mouse 530 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503
		DDT	346..411	CDD:214726
		WHIM1	505..554	CDD:292246
		WHIM2	637..666	CDD:292247
		WHIM3	775..813	CDD:292248
		PHD_RSF1	1064..1109	CDD:277018	12/55 (22%)
		PHD	1244..1284	CDD:214584	3/39 (8%)
		Bromo_Acf1_like	1349..1463	CDD:99936	44/115 (38%)
Cecr2	NP_001355635.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..237		12/68 (18%)
		Bromo_gcn5_like	418..518	CDD:99941	40/100 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..667
		PHA03247	<558..1031	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..796
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	827..868
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	884..1020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1072
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1131..1308
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1331..1368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1396..1453
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848858
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740