Protein Alignment Acf and Ep300

DIOPT Version :9

• Sequence 1: NP_536734.2
• Gene: Acf / 43751
• FlyBaseID: FBgn0027620
• Length: 1476
• Species: Drosophila melanogaster
• Sequence 2: XP_006521152.1
• Gene: Ep300 / 328572
• MGIID: 1276116
• Length: 2422
• Species: Mus musculus
• Alignment Length: 1053
• Identity: 186/1053 - (17%)
• Similarity: 316/1053 - (30%)
• Gaps: 387/1053 - (36%)

  Fly   594 EPEKREALVEKLKKSIAELHA-------QSDQQHRKHELQMLKLHSQLFNFLVYLGMDRCYRKYY 651
            :||||:.:.::|   :..|||       |::.:.|:..|...:....:.|.     |..|
Mouse   332 DPEKRKLIQQQL---VLLLHAHKCQRREQANGEVRQCNLPHCRTMKNVLNH-----MTHC----- 383

  Fly   652 VLESMPGIFVEHSPDSLDTCLEQPITNKSQIEIRQQSALPKN--RKDLRVYL-LKLYGDDEKKTK 713
              :|.....|.|...|                 ||..:..||  |.|..|.| ||..||
Mouse   384 --QSGKSCQVAHCASS-----------------RQIISHWKNCTRHDCPVCLPLKNAGD------ 423

  Fly   714 KKAKHSLENKENQEHRLNGS----AEPMDV---ESDSPEAPTHFELLMCSGDKRSCIVHDSRNGQ 771
                     |.||:..|.|:    ..|..:   :..:|...|..::             |..:.:
Mouse   424 ---------KRNQQSILTGAPVGLGNPSSLGVGQQSTPSLSTVSQI-------------DPSSIE 466

  Fly   772 RQRWAYI-----YKAEEI--DELIKALN----PNGLREYELLQELSVLRSLIEQHAKTCPV---- 821
            |   ||.     |:..:|  ...::|.|    |:|       |....:||:....|....|
Mouse   467 R---AYAALGLPYQVNQIPPQPQVQAKNQQSQPSG-------QSPQGMRSVNNMSASPMGVNGGV 521

  Fly   822 -----DLLSLENETMRKKFMAAMESETNRKYGEANFG------LPNGT--------DLNEVMRLH 867
                 :|||   ::|....:.:.....:...|.|:.|      .|:.|        |:.:.:|.|
Mouse   522 GVQTPNLLS---DSMLHSTINSQNPMMSENAGVASLGPLPTAAQPSSTGIRKQWHEDITQDLRNH 583

  Fly   868 LVDRIIQ-------------------------FENDIYTGDLGRLKV------------KDMEKW 895
            ||.:::|                         .|.|:|.....|.:.            |::|:.
Mouse   584 LVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEK 648

  Fly   896 RSDLLGGNYDAQCKLQWGPG-GKLEDEAGSDNESHETHEEDDGALLGKYARKPYRDPGMYLAASA 959
            |...|    ..|..|...|| |.:....||:.....|         |.....|..||.| :..|.
Mouse   649 RRTRL----QKQNMLPNAPGMGPVPMNTGSNMGQQPT---------GMTTNGPVPDPSM-IRGSV 699

  Fly   960 DTKPLPDSDDEED-QHTNAVSIPIAVHNMASALLQVEQAIGKRFLKEPYGMKKWDPKQEALKLAC 1023
            ....:|....:.. .....:::|                      :.|.|.::..|.|...:||.
Mouse   700 PNHMMPRMTPQPGLNQFGQMNMP----------------------QPPIGPRQPSPLQHHGQLAQ 742

  Fly  1024 DSRLH------------QWEVSLMESTSFAQVFLHLNILHDCIQWRRSTNKSLCKVCRRGSDPEK 1076
            ...|:            ..:...:..|.|..            |....||..|.....:....:.
Mouse   743 SGSLNPPMGYGPRMQQASGQNQFLSQTQFTS------------QGMNVTNMPLAPSSGQAPVSQA 795

  Fly  1077 MLLCDEC----------NAGTHMFCLK-------------------------------------- 1093
            .:....|          :.|:|:.|..
Mouse   796 QMSSSSCPVNSPIMPPGSQGSHIHCPTLPQQAHQNSPSPVPSRTPTPHHTPPSIGNQPPPATAIP 860

  Fly  1094 ---PKLRSVPPGNWYCNDCVKSLGLSNGQNEKDKKQATKKKRKFIVEEEDDEATDEEEEEKKDDD 1155
               |...::|||     ....||..|:.|..........:.:..:...   .:.|:.:::.:...
Mouse   861 TPVPTPPAIPPG-----PQPPSLHPSSRQTPTPPTHLPPQVQPSLPAA---PSADQSQQQPRSQQ 917

  Fly  1156 MTDEDA----------EHENEKHDEDVEDDESVTSTP--SSSRVNGRILRRPRTRPTSRRLTSKE 1208
            .|....          :.........|..:..|::.|  ||:.||.:.:  |..:|      |:|
Mouse   918 STAVSVPTPTAPLLPPQPSTPLSQPAVSIEGQVSNPPSTSSTEVNSQTI--PEKQP------SQE 974

  Fly  1209 IEEHAQEDVDSGDVSDDASLTAGEDTIEDESDEEKVCQKCFYDGGEIKCVQCRLFFHLECVHLKR 1273
            ::..::.:||..:.:|    ...|||.|.:.::.||
Mouse   975 VKMESKMEVDKPEPAD----AQPEDTKEAKGEDVKV----------------------------- 1006

  Fly  1274 PPRTDFVCKTCKPMPQRPRRRHSNMNGDHDRDEEEPKAKRPRNSLRLSIDKTARPSNGNNNNNNN 1338
                         .|.....|...:..|...:||:|.....::|          |:.|
Mouse  1007 -------------EPTEMEERGPELKTDGKEEEEQPSTSATQSS----------PAPG------- 1041

  Fly  1339 NSSVNNNNHRRSGRRTNEHMPLNSAALYDLLEQIMKHKAAWPFLRPV--LTSEVPDYHQIIKTPM 1401
                      :|.::..:...|..|.:..|.....:...:.||.:||  ....:|||..|:|:||
Mouse  1042 ----------QSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPM 1096

  Fly  1402 DLAKIKSKLNMGAYQLNEELLSDIQLVFRNCDLYNVEGNEIYDAGCQLERFV----------IDR 1456
            ||:.||.||:.|.||...:.:.||.|:|.|..|||.:.:.:|....:|....          :..
Mouse  1097 DLSTIKRKLDTGQYQEPWQYIDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGY 1161

  Fly  1457 CRDMQLPFRPSDM 1469
            |...:|.|.|..:
Mouse  1162 CCGRKLEFSPQTL 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503
		DDT	346..411	CDD:214726
		WHIM1	505..554	CDD:292246
		WHIM2	637..666	CDD:292247	5/28 (18%)
		WHIM3	775..813	CDD:292248	11/48 (23%)
		PHD_RSF1	1064..1109	CDD:277018	9/95 (9%)
		PHD	1244..1284	CDD:214584	1/39 (3%)
		Bromo_Acf1_like	1349..1463	CDD:99936	35/125 (28%)
Ep300	XP_006521152.1	KIX	567..647	CDD:366953	11/79 (14%)
		PABP-1234	<714..848	CDD:130689	18/167 (11%)
		Merozoite_SPAM	959..>1048	CDD:284533	25/169 (15%)
		Bromo_cbp_like	1050..1157	CDD:99927	33/106 (31%)
		RING_CBP-p300	1169..1251	CDD:276805	2/6 (33%)
		PHD_p300	1252..1286	CDD:277116
		HAT_KAT11	1315..>1526	CDD:369758
		ZZ_CBP	1677..1717	CDD:239077
		ZnF_TAZ	1738..1816	CDD:214717
		Med15	1968..>2344	CDD:312941
		Creb_binding	2016..2109	CDD:370251
		Med15	88..>328	CDD:312941
		zf-TAZ	348..415	CDD:366931	18/95 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900