DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acf and Baz1a

DIOPT Version :9

Sequence 1:	NP_536734.2	Gene:	Acf / 43751	FlyBaseID:	FBgn0027620	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	XP_038968148.1	Gene:	Baz1a / 314126	RGDID:	1306199	Length:	1583	Species:	Rattus norvegicus

Alignment Length:	1701	Identity:	429/1701 - (25%)
Similarity:	725/1701 - (42%)	Gaps:	362/1701 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPICKREGFDLNQKEGKNETFHDNDQVFCCYITKRIFRDYEHYFRHVMVINSTVWQCEATGKENL 65
            ||:..|:.|...:..|   ....:::||.|.:|..|||.|:.:|...::.||.||.|..||:..|
  Rat     1 MPLLHRKPFVRQKPPG---DLRPDEEVFYCKVTNEIFRHYDDFFERTILCNSLVWSCAVTGRPGL 62

  Fly    66 TYEEAVKSERAARKKMEQFKQSLRAPVLLVVEHAQQSAVNTLNMIVAKFLRKRYFIGEEVSVQAK 130
            ||:||::|||.|::.::.|.:.|..|||.:.....:|.::.:...:..:::.|||:.|.|.| .:
  Rat    63 TYQEALESERKAKQDLQSFPEPLIIPVLYLTNLTHRSRLHEICDDIFAYIKDRYFVEETVEV-IR 126

  Fly   131 KNATYTVLGVKLDKNMPEPL------NG----------IYEDTDN-------------------- 159
            .|.|.  |..::.:.:| ||      ||          :..|:|:
  Rat   127 NNGTR--LQCRILEVLP-PLHQNGFANGHMSSVDGETIVISDSDDSETQSSSFQHGKKKDAIDPL 188

  Fly   160 -LVYRLRPNKGDPSAELDLPFRQLRRSRMEFNLENLSMFIKSNVSRVDGLLRPKPEAYKQY-VTD 222
             ..||::|.|.:......:...|:.|.:..|:.:.|.:|:|.:....||:::.|..::..| :.:
  Rat   189 LFRYRVQPTKKEMYESAVVKATQISRRKHLFSRDKLKLFLKQHCEPQDGVIKIKASSFSTYNIAE 253

  Fly   223 PGVNFSTIFIGKMPRYSPAKIKKPDGKKQSTLNKYI-------VAGEATAAKSKAKA-------- 272
            .  :||..|    |...|..|..|..:::....|.|       :|.:.|.|:.::||
  Rat   254 Q--DFSYFF----PDDPPTFIFSPANRRRGRPPKRISFGQEDNIASKQTIARCRSKAIKERDKLL 312

  Fly   273 -KSDAKSLAEELERVKREK----EA----------------KLIELE--KQKAEKKAQLIERVEN 314
             :.:.::||.|..::||||    ||                |::|.|  |:|.||:...|||.:.
  Rat   313 KQEEMRALAFEKAKLKREKADALEARKREREDREKKREELKKIVEEERLKKKEEKERLKIEREKE 377

  Fly   315 ECNLLLQK-------------TDDLERTDQKVLPRYRQIVTLLPEHLLGDAFMMREFMHTYTGLL 366
            ...|..:|             .:|:|..|.|.||....:.|.||..:.|||.|:.||::.:..|.
  Rat   378 REKLREEKRKYMEYLKQWSKPREDMECDDLKELPEPTPVKTRLPPEVFGDALMVLEFLNAFGELF 442

  Fly   367 SGIEVFRQNLSFYEMTRALTAREIAGPLSDILLVLLGTVFDLQKEEEEECA---VTYLDRAAQTQ 428
            ...:.|.:.::...:..||...:..|||.::|...|..:|....|||||.|   :|..|....|:
  Rat   443 DLQDEFPEGVTLEVLEEALVGNDSEGPLCELLFFFLTAIFQAMAEEEEEVAKEQITDADTKDLTE 507

  Fly   429 ------EPYWS--MAQAAKSHLYAKRHFSFKVNELPLDALTLSEVLRLHLLGSGAFVNEKAERWR 485
                  :|..|  .|.||.:..:.:.|....:..|.||:.||||:||||:|.|||.|.....::|
  Rat   508 ALDEDADPTKSALSAVAALAAAWPQLHQGCSLKSLDLDSCTLSEILRLHILASGADVTSANAKYR 572

  Fly   486 VMYRNGYSSKEDPGLELRLEHSHILRILKNHSVYQLKFKDIMLLIRCLMSQIMTYSGTINLIEER 550
            ...|.|:.:.:|..:||||.:..:::.|.:.:||.|...:.|.::..|..:::|...|.:.||:.
  Rat   573 YQKRGGFDATDDACMELRLSNPSLVKKLSSTAVYDLTPGEKMKILHALCGKLLTLVSTRDFIEDY 637

  Fly   551 MEQTAKARQDLRALVVGENKR---LAAVEINRKKLTQMHHLEVNGVEPEKREALVEKLKK----- 607
            ::...:|:|:.|.|...::::   ..|..|.|:|..::...|      :|.:...||||:
  Rat   638 VDVLRQAKQEFRELKAEQHRKEREATAARIRRRKEEKLKEQE------QKMKEKQEKLKEDEQRT 696

  Fly   608 SIAEL------------------------------------HAQS-------------------- 616
            |.|:|                                    |.:|
  Rat   697 SAADLGEEGREDFDTSADSKEIERKDLDPDVVTEDEDDLGSHKRSRRGKAGQTAVKQCIKQEEMN 761

  Fly   617 ----------------DQQHRKHELQML-KLHSQLFNFLVY-LGMDRCYRKYYVLESMPGIFVEH 663
                            .|:|::.|.::| |:.|.:....:: ||.||.||:|:|..|:||:|:|.
  Rat   762 YCIKQEPLTADAEEALRQEHQRKEKELLDKIQSAIACTNIFPLGRDRLYRRYWVFPSIPGLFIEE 826

  Fly   664 SPDSL--DTCLEQPITNKSQIEIRQQSALPKNRKDLRVYLLKLYGDDEKKTKKKAKHSLENKENQ 726
            ....|  |..|.:|    |......|...|      ||.:                      :.:
  Rat   827 DYSGLTEDMLLPRP----SSFHSNAQPHSP------RVSI----------------------KTE 859

  Fly   727 EHRLNGSAEPMDVESDSPEAPTHFELLMCSGDKRSCIVHDSRNGQRQRWAYIYKAEEIDELIKAL 791
            |..::.|...:|      :.|....||:...      ||     :..||.:....|::|:||:||
  Rat   860 ESFMSESTSSLD------QGPFDDSLLLPKP------VH-----KPNRWCFYSSCEQLDQLIEAL 907

  Fly   792 NPNGLREYELLQELSVLRSLIEQHAKTCPVDLLSLENETMRKKFMAAMESETNRKYGEANFGLPN 856
            |..|.||..|.:      :|:::.::.| ..|.....|    ||..:.:.:.:.| ..::.|...
  Rat   908 NSRGHRESALKE------TLLQEKSRIC-AQLAHFSEE----KFHFSDKPQADSK-PVSSRGRSA 960

  Fly   857 GTDLNEV-----MRLHLVDRIIQFENDIYTGDLGRLKVKDMEKWRSDLLGGNYDAQCKLQWGPGG 916
            ..|.:::     :.|.|.|.::..|:.||.|.||.:||.|.:.|||.|..|.|:
  Rat   961 ACDTSQMSAERQLELRLRDFLLDIEDRIYQGTLGAIKVTDRQVWRSALENGRYE----------- 1014

  Fly   917 KLEDEAGSDNESHETHEEDDGALLGKYARKPYRDPGMYLAASADTKPLPDSDDEEDQHTNAVSIP 981
             |..|...:|...:...:|...:..:.||...||  ..|....:|.....:.....|     |:.
  Rat  1015 -LLSEESKENGVSKAVNDDVEEMEIEQARVIVRD--RLLGLKTETPSTVSTSTSTPQ-----SVS 1071

  Fly   982 IAVHNMASALLQVEQAIGKRFLKEPYG----------------MKKWDPKQEALK-------LAC 1023
            ..||.:|:||.|:||.|.:||||.|.|                .||.:..|.:::       .:.
  Rat  1072 NVVHYLATALFQIEQGIERRFLKAPLGNTEINKDQKGARKKKNKKKREDDQSSVRDDGSDSGRSY 1136

  Fly  1024 DSRLHQWEVSLMESTSFAQVFLHLNILHDCIQWRRSTNKSLCKVCRRGSDPEKMLLCDECNAGTH 1088
            .:.|.:|..||:.|.|.:||||||:.|...:.|.:|...:.||:||:..|.|.|:|||.|:.|.|
  Rat  1137 KTVLDRWRESLLSSASLSQVFLHLSTLDRSVMWSKSILNARCKICRKKGDAENMVLCDGCDRGHH 1201

  Fly  1089 MFCLKPKLRSVPPGNWYCNDCVKSLGLSNGQNEKDKKQATKKKRKFIVEEEDDEATDEEEEEKKD 1153
            .:|::|||::||.|:|:|.:|         :.::..::.:.::|..:..:|:.|...|.::.:.|
  Rat  1202 TYCVRPKLKTVPDGDWFCPEC---------RPKQRSRRLSSRQRPSLESDEEMEEGMEGDDGEVD 1257

  Fly  1154 DDMTDEDAEHENEKH----DEDVEDDESVTSTPSSSRVNGR--ILRRPRTRPT----SRRLTSKE 1208
            ||  |||.:.|.|::    ||:..|:|...|.|...|...|  |..|.|..|:    |:|.....
  Rat  1258 DD--DEDGQSEEEEYEVEQDEEDSDEEEALSPPKRGRPQVRLPIKTRGRFGPSFSSRSQRQDPGR 1320

  Fly  1209 IEEHAQEDVDSGDVSDDASLTAGEDTIEDESDEEKVCQKCFYDGGEIKCVQCRLFFHLECVHLKR 1273
            ....:|:...    ...||.|||.:..:..|......:.........:             |...
  Rat  1321 YPSRSQQSTP----KTTASKTAGRNLRKTRSAPPTETRSLRLGSRSTR-------------HSPN 1368

  Fly  1274 PPRTDFVCKTCKPMPQRPRRRHSNMNGDHDRDEEEPKAKRPRNSL---------RLSIDKTARPS 1329
            ..:.|...:...|..:|..|:.::...:|.......:....|.|:         |||:..:....
  Rat  1369 ALQADVFVELLSPRGKRRVRKSADNTPEHSPSLTNLRVSTSRPSVQLIPLNSAERLSLQDSESKR 1433

  Fly  1330 NGNNNNNNNNSSVNNNNHRRSGRRTNEHMPLNSAALYDLLEQIMKHKAAWPFLRPVLTSEVPDYH 1394
            .|....:..:|.| ..|.|.|||:...|   ..:|...|:.::::|..:||||:.|...:||||:
  Rat  1434 RGRKRQSTESSPV-PLNRRSSGRQGGVH---ELSAFEQLVVELVRHDDSWPFLKLVSKIQVPDYY 1494

  Fly  1395 QIIKTPMDLAKIKSKLNMGAYQLNEELLSDIQLVFRNCDLYNVEGNEIYDAGCQLERFVIDRCRD 1459
            .|||.|:.|..|:.|:|...|:|..|.:.||:|:|.||..||........||.:|:.|...:.:.
  Rat  1495 DIIKKPIALNIIREKVNKCEYKLASEFIEDIELMFSNCFEYNPRNTSEAKAGTRLQAFFHIQAQK 1559

  Fly  1460 MQLPFRPSDMN 1470
            :.|...||:::
  Rat  1560 LGLHVSPSNVD 1570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503	35/98 (36%)
		DDT	346..411	CDD:214726	16/64 (25%)
		WHIM1	505..554	CDD:292246	10/48 (21%)
		WHIM2	637..666	CDD:292247	13/29 (45%)
		WHIM3	775..813	CDD:292248	13/37 (35%)
		PHD_RSF1	1064..1109	CDD:277018	22/44 (50%)
		PHD	1244..1284	CDD:214584	2/39 (5%)
		Bromo_Acf1_like	1349..1463	CDD:99936	39/113 (35%)
Baz1a	XP_038968148.1	WAC_Acf1_DNA_bd	23..122	CDD:402251	35/98 (36%)
		DDT	422..483	CDD:214726	15/60 (25%)
		WHIM1	590..635	CDD:406127	10/44 (23%)
		PTZ00121	<646..793	CDD:173412	23/152 (15%)
		WSD	799..925	CDD:406128	44/180 (24%)
		PHD_BAZ1A	1177..1222	CDD:277097	22/44 (50%)
		Bromo_Acf1_like	1449..1562	CDD:99936	41/115 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352460
Domainoid	1	1.000	78	1.000	Domainoid score	I8610
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	458	1.000	Inparanoid score	I1519
OMA	1	1.010	-	-		QHG45550
OrthoDB	1	1.010	-	-		D368751at33208
OrthoFinder	1	1.000	-	-		FOG0005585
OrthoInspector	1	1.000	-	-		oto97281
orthoMCL	1	0.900	-	-		OOG6_107600
Panther	1	1.100	-	-	LDO	PTHR46510
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4556
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770