DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acf and Pbrm1

DIOPT Version :9

Sequence 1:	NP_536734.2	Gene:	Acf / 43751	FlyBaseID:	FBgn0027620	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	XP_006252748.1	Gene:	Pbrm1 / 306254	RGDID:	1565549	Length:	1726	Species:	Rattus norvegicus

Alignment Length:	796	Identity:	161/796 - (20%)
Similarity:	277/796 - (34%)	Gaps:	211/796 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   777 YIYKAEEIDELIKALNPNGLREYELLQELSVLRSLIEQHAK------------TCPV-DL-LSLE 827
            |...::.|| |:|......:.||:.:..|:....|:..:||            .|.: || |...
  Rat   106 YEVVSQPID-LMKIQQKLKMEEYDDINLLTADFQLLFNNAKAYYKPDSPEYKAACKLWDLYLRTR 169

  Fly   828 NETMRKKFMAAMESETNRKYGEANFG-LPNGTD---LNEVMRLHLVDRIIQFENDIYTGDLGRLK 888
            ||.::|   ...:.|.:.:.|:.|.| :.:|:.   |.|::. .|::.|:     :.|...|||.
  Rat   170 NEFVQK---GEADDEDDDEDGQDNQGTMADGSSPGYLKEILE-QLLEAIV-----VATNPSGRLI 225

  Fly   889 VKDMEKWRSDLLGGNYDAQCKLQWGP------GGKLEDEAGSDNESHETHEEDDGALLGKYARKP 947
            .:..:|..|.:...:|.|..|   .|      ..::::  ||....|...::.|  ||.|.| |.
  Rat   226 SELFQKLPSKVQYPDYYAIIK---EPIDLKTIAQRIQN--GSYKSIHAMAKDID--LLAKNA-KT 282

  Fly   948 YRDPGMYLAASADT-KPLPDSDDEEDQHTNAVSIPIAVH---NMASALL---------------- 992
            |.:||..:...|:: |.:......|.:|.......:.:.   |:|:|.|
  Rat   283 YNEPGSQVFKDANSIKKIFYMKKAEIEHHEMTKSSLRIRTATNLAAARLTGPSHNKSSLDEERNP 347

  Fly   993 -----QVEQAI-GKRFLKEPYGMKKWDPKQEALKLACDSRLHQWEVSLMESTSFAQVFLHLNILH 1051
                 :.::|: |.|.......::.....:|...||. :|..:.|......|||..|....:.|:
  Rat   348 TSKCYRNKRAVQGGRLSAITMALQYGSESEEDAALAA-ARYEEGESEAESITSFMDVSNPFHQLY 411

  Fly  1052 DCIQWRRSTNKSLCKVCRRGSD----------PEKMLLCD---ECNAGTHMFCLKPKLRSVPPGN 1103
            |.:           :.||....          |.|....|   :......:..::.||::.....
  Rat   412 DTV-----------RSCRNNQGQLIAEPFFHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYET 465

  Fly  1104 WYCNDCVKSLGLSNGQNEKDKKQATKK---KRKFIVEEEDDEATDEEEEEKKDDDMTDEDAEHEN 1165
            ....:|..:|...|.:.......|..|   |.:.:::.:..|....::.|..|..::...::..:
  Rat   466 LDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGS 530

  Fly  1166 EKHDEDVEDDESV-TSTPSSSRVNGR---------ILRRPRTRPTSRRLTS-------------- 1206
            .|...:..|.|.: ....|||:.|.|         ::...|...:.|||..
  Rat   531 AKRKRNTHDSEMLGLRRLSSSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDY 595

  Fly  1207 ----------KEIEEHAQEDVDSGD--VSDDASL---------TAGEDTIEDESDEEKVCQKCFY 1250
                      |.||.:.:.|..:|:  :.:|..|         ..|.....|....||:.:.
  Rat   596 YKIILEPMDLKIIEHNIRNDKYAGEEGMMEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKD--- 657

  Fly  1251 DGGEIKCVQCRLFFHLECVHLKRPPRTDFVCKTCKPMPQRPRRRHSNMNGDHDRDEEEPKAKRPR 1315
                                 ||        |...|:|.             |.|...||.|..|
  Rat   658 ---------------------KR--------KELGPLPD-------------DDDMASPKLKLSR 680

  Fly  1316 NSLRLSIDKTARPSNGNNNNNNNNSSVNNNNHRRSGRRTNEHMPLNSAALYDLLEQIMKHKAAWP 1380
            .| .:|..|:...:......|....:|.|...:| |||               |..|
  Rat   681 KS-GVSPKKSKYMTPMQQKLNEVYEAVKNYTDKR-GRR---------------LSAI-------- 720

  Fly  1381 FLRPVLTSEVPDYHQIIKTPMDLAKIKSKLNMGAYQLNEELLSDIQLVFRNCDLYNVEGNEIYDA 1445
            |||....||:|||:..||.|||:.||:|.:....||..:.::.|..::|.|...||...:.||..
  Rat   721 FLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKD 785

  Fly  1446 GCQLERFVIDRCRDMQ 1461
            ...|.:.:::..||::
  Rat   786 ALVLHKVLLETRRDLE 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503
		DDT	346..411	CDD:214726
		WHIM1	505..554	CDD:292246
		WHIM2	637..666	CDD:292247
		WHIM3	775..813	CDD:292248	9/35 (26%)
		PHD_RSF1	1064..1109	CDD:277018	7/57 (12%)
		PHD	1244..1284	CDD:214584	3/39 (8%)
		Bromo_Acf1_like	1349..1463	CDD:99936	34/113 (30%)
Pbrm1	XP_006252748.1	Bromo_polybromo_I	65..177	CDD:99954	18/74 (24%)
		Bromo_polybromo_II	203..305	CDD:99948	28/115 (24%)
		Bromo_polybromo_III	404..505	CDD:99951	15/111 (14%)
		Bromo_polybromo_IV	556..659	CDD:99949	16/126 (13%)
		Bromo_polybromo_V	695..799	CDD:99946	35/127 (28%)
		Bromo_polybromo_VI	812..919	CDD:99956
		BAH_polybromo	994..1111	CDD:240068
		BAH_polybromo	1192..1310	CDD:240068
		HMG-box	1417..1481	CDD:238037
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900