DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acf and BAZ2B

DIOPT Version :9

Sequence 1:	NP_536734.2	Gene:	Acf / 43751	FlyBaseID:	FBgn0027620	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	XP_024308593.1	Gene:	BAZ2B / 29994	HGNCID:	963	Length:	2259	Species:	Homo sapiens

Alignment Length:	1861	Identity:	352/1861 - (18%)
Similarity:	567/1861 - (30%)	Gaps:	821/1861 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 GKENLTYEEAVKSERAARKKMEQFKQSLRAPVLLVVEHAQQSAVNTLNMIVAKFLRKRYFIGE-- 123
            |..:.|...:..|..:.|:::.. ::.||.|    :|:..|           :..|.|.|.|.
Human   736 GTSSSTLTSSPHSGTSKRRRVTD-ERELRIP----LEYGWQ-----------RETRIRNFGGRLQ 784

  Fly   124 -EVSVQAKKNATYTVLGVKLDKNMPEPL-----NGIYE-DTDNLVYRLRPNKGD-------PSA- 173
             ||       |.|...|.|| :..||.:     |||.: ..||..:..:...||       |..
Human   785 GEV-------AYYAPCGKKL-RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGM 841

  Fly   174 ------ELDL----------------PFRQLRR--SRMEF------NLENLSMFIKSNVSRVDGL 208
                  |.|:                |.||..|  |||..      |:.|...     :...|..
Human   842 QWCLLKEEDVIPRIRAMEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEF-----LDNADAK 901

  Fly   209 LRPKPEAYKQYVTDPGVNFSTIFIGKMPRYSPAKIKKPDGKKQSTLNKYIVAGEATAAKSKAKAK 273
            |..|.:|  |.:........  .:.|:.:...|::.| :.|||..:         .||:.|.|.|
Human   902 LLRKLQA--QEIARQAAQIK--LLRKLQKQEQARVAK-EAKKQQAI---------MAAEEKRKQK 952

  Fly   274 SDAKSLAEELERVKR------EKE-------------------AKLIELEKQ------------- 300
            ...|.:.:: |::||      |||                   |||:|.||:
Human   953 EQIKIMKQQ-EKIKRIQQIRMEKELRAQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVL 1016

  Fly   301 ------------------------------KAEKKAQLIERVENE-------------------- 315
                                          :|.|||:..||::.|
Human  1017 LKHQELERHRLDMVWERERRRQHMMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLEL 1081

  Fly   316 --CNLLLQKTDDLERTDQKVLPRYRQIVTL-LPEHLLGDAFMMREFMHTYTGLLS-GIEVFRQNL 376
              ...|.:..:|:...|||.||...:|..| |......|..|:.:|:..:..:|. .:.:...||
Human  1082 EMAKELKKPNEDMCLADQKPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNL 1146

  Fly   377 SFYEMTRALTAREIAGPLSDILLVLL-GTVFD------------------------------LQK 410
            |..: ...|...:..|.:.|:|:.|| ..|.|                              ||.
Human  1147 SVLQ-EGLLNIGDSMGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQI 1210

  Fly   411 EEEEECAVTYLDRAAQTQEPYWSMAQAAKSHLYAKRH--FSFKVNELPLDALTLSEVLRLHLLGS 473
            ..|..|..|.|..:.:|        :|.::|..|::.  .:|.:|||......:||:.:    ..
Human  1211 FMEAHCGQTELTESLKT--------KAFQAHTPAQKASVLAFLINELACSKSVVSEIDK----NI 1263

  Fly   474 GAFVNEKAERWRVMYRNGYSSKEDPGLELRLEHSHILRILKNHSVYQLKFKDIMLLIRCLMSQIM 538
            ....|.:.::|.|              |.:|....|:...|...      :|.
Human  1264 DYMSNLRRDKWVV--------------EGKLRKLRIIHAKKTGK------RDT------------ 1296

  Fly   539 TYSGTINLIEERMEQTAKARQDLRALVVGENKRLAA--------------------------VEI 577
              ||.|:|.||        :..|.....|..:|...                          .|.
Human  1297 --SGGIDLGEE--------QHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEEDKED 1351

  Fly   578 NRKKLTQMHHLEVNGVEPEKREALVEKLKKSIAELHAQSDQQHRK-----HELQMLKLHSQLFNF 637
            .:.|.|.:...|..|    .:.|.||:|:|.|.:|..|..|..||     |.|:.
Human  1352 KKGKKTDICEDEDEG----DQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRS---------- 1402

  Fly   638 LVYLGMDRCYRKYYVLESMPGIFV--------------------------------EHSPDSL-- 668
             |..|.||..|:|::|....||||                                |.|.|||
Human  1403 -VMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNC 1466

  Fly   669 ---DTC------LEQPITNKSQIEIRQQSALPKNRKDLRVYLLKLYGDDEKKTKK---------- 714
               |.|      .|:..||   :.:::..:..|..|.|.|  .|:..:.|..|.|
Human  1467 SNTDHCEQKEDLKEKDNTN---LFLQKPGSFSKLSKLLEV--AKMPPESEVMTPKPNAGANGCTL 1526

  Fly   715 ----KAKHSLENKENQEHRLN------------GSAEP----MDVESDS---------------- 743
                ..||||.:.::...:.|            ||:.|    ..:.:|.
Human  1527 SYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWFSLL 1591

  Fly   744 PEAP------THFELLMCS---------------------------------------------- 756
            |..|      ||.::...|
Human  1592 PRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPLQVKGGVSM 1656

  Fly   757 ----------------------------------GDKRSCIVHDSRNGQRQR------------- 774
                                              |:..|.:..:..:.:.:.
Human  1657 MGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSESPVPQNEKATSAQP 1721

  Fly   775 ------------------------WAYIYKAEEIDELIKALNPNGLREYELLQELSVLRSLIEQH 815
                                    |..|...|::..|:|.|:..|:||       ..|:..|::|
Human  1722 AAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIRE-------KALQKQIQKH 1779

  Fly   816 AKTCPVDLLSLENETMRKKFMAAMESETNRKYGEANFGLPNGTDLNEVMRLHLVDRIIQFENDIY 880
                 :|.::  ...::.|.:|.:|...|.:              |:|.| .:|:. ...|....
Human  1780 -----LDYIT--QACLKNKDVAIIELNENEE--------------NQVTR-DIVEN-WSVEEQAM 1821

  Fly   881 TGDLGRL-KVKDMEKWRSDLLGGNYDAQCKLQ---W---GPGGKLEDEAGSDNESH-ETHEEDDG 937
            ..||..| :|:|:|:         ..|...||   |   .|..:.||....:::|. :..:|.||
Human  1822 EMDLSVLQQVEDLER---------RVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDG 1877

  Fly   938 ALLGKYARKPYRDPGMYLAASADTKPLPDSDDEEDQHT------NAVSIPIAVHNMASALLQVEQ 996
            ...|                          :||...|.      |.:.|.:      :.|..:|:
Human  1878 EFTG--------------------------EDESSAHALERKSDNPLDIAV------TRLADLER 1910

  Fly   997 AIGKRFLKEPYGMKKWDPKQEALKLACDS--------------------------RLHQWEVSLM 1035
            .|.:|:||.|.        ...:::..|:                          .|..|..:|.
Human  1911 NIERRYLKSPL--------STTIQIKLDNVGTVTVPAPAPSVSGDGDGIEEDIAPGLRVWRRALS 1967

  Fly  1036 ESTSFAQVFLHLNILHDCIQWRRSTNKSLCKVCRRGSDPEKMLLCDECNAGTHMFCLKPKLRSVP 1100
            |:.|.|||.|.:..|...|.|.:|..|..|::||:|.:.|.:||||.|:.|.|.:|.:||:.::|
Human  1968 EARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIP 2032

  Fly  1101 PGNWYCNDCVKSLGLSNGQNEKDKKQATKKKRKFIVEEEDDEATDEEEEEKKDDDMTDEDAEHEN 1165
            .|:|:|..|:..   ::||..|.||...|.|:           |:|.::.|| ..:|.
Human  2033 DGDWFCPACIAK---ASGQTLKIKKLHVKGKK-----------TNESKKGKK-VTLTG------- 2075

  Fly  1166 EKHDEDVEDDESVTSTPSSSRVNGRILRRPRTRPTSRRLTSKEIEEHAQEDVDSGDVSDDASLTA 1230
                 |.||::|.:::.|..|.|                  |::::...|:..|.::|...|.|:
Human  2076 -----DTEDEDSASTSSSLKRGN------------------KDLKKRKMEENTSINLSKQESFTS 2117

  Fly  1231 GEDTIEDESDEEKVCQKCFYDGGEIKCVQCRLFFHLECVHLKRPPRTDFVCKTCKPMPQRPRRRH 1295
                                                    :|:|.|.|
Human  2118 ----------------------------------------VKKPKRDD----------------- 2125

  Fly  1296 SNMNGDHDRDEEEPKAKRPRNSLRLSIDKTARPSNGNNNNNNNNSSVNNNNHRRSGRRTNEHMPL 1360
                                                                       ::.:.|
Human  2126 -----------------------------------------------------------SKDLAL 2131

  Fly  1361 NSAALYDLLEQIMKHKAAWPFLRPVLTSEVPDYHQIIKTPMDLAKIKSKLNMGAYQLNEELLSDI 1425
            .|.    :|.::..|:.|||||.||....||.|.::||.|||.:.|:.||:.|.|...|....|:
Human  2132 CSM----ILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETFALDV 2192

  Fly  1426 QLVFRNCDLYNVEGNEIYDAGCQLERFVIDRCRDMQLPFRP 1466
            :|||.||:.:|.:.::|..||..:.::...:..|   .|:|
Human  2193 RLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTD---TFKP 2230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503	13/66 (20%)
		DDT	346..411	CDD:214726	17/96 (18%)
		WHIM1	505..554	CDD:292246	9/48 (19%)
		WHIM2	637..666	CDD:292247	13/60 (22%)
		WHIM3	775..813	CDD:292248	10/37 (27%)
		PHD_RSF1	1064..1109	CDD:277018	19/44 (43%)
		PHD	1244..1284	CDD:214584	4/39 (10%)
		Bromo_Acf1_like	1349..1463	CDD:99936	36/113 (32%)
BAZ2B	XP_024308593.1	Nucleoporin_FG2	42..>226	CDD:330420
		HAT_MBD	761..833	CDD:238691	25/94 (27%)
		TPH	903..>1089	CDD:316391	35/200 (18%)
		DDT	1117..1179	CDD:214726	15/62 (24%)
		WSD	1400..>1432	CDD:317927	12/42 (29%)
		WSD	<1740..1779	CDD:317927	11/45 (24%)
		PHD_BAZ2B	1995..2043	CDD:277100	20/47 (43%)
		Bromo_BAZ2A_B_like	2128..2224	CDD:99935	35/99 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900