DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acf and Baz1b

DIOPT Version :9

Sequence 1:	NP_536734.2	Gene:	Acf / 43751	FlyBaseID:	FBgn0027620	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	NP_035844.2	Gene:	Baz1b / 22385	MGIID:	1353499	Length:	1479	Species:	Mus musculus

Alignment Length:	1834	Identity:	356/1834 - (19%)
Similarity:	599/1834 - (32%)	Gaps:	736/1834 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PICKREGFDLNQKEGKNETFHDNDQVFCCYITKRIFRDYEHYFRHVMVINSTVWQCEATGKENLT 66
            |:..|:.|.|      .:.....:.:|....|:..||..|.|...:...:..:|.|::||...||
Mouse     3 PLLGRKPFPL------VKPLPGEEPLFTIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQLT 61

  Fly    67 YEEAVKSER-AARKKMEQFKQSLRAPVLLVVEHAQQSAVNTLNMIVAKFLRKRYFIGEEVSVQAK 130
            ::||.:.|: .|....|:|.......||.:|.|...|....::....:.:.| |.:|||...:..
Mouse    62 HKEAWEEEQEVAELLKEEFPNWYEKLVLEMVHHNTASLEKLVDSAWLEIMTK-YAVGEECDFEVG 125

  Fly   131 KNATYTVLGVKLDKNMPEPLNGIYEDT-------------------------------------- 157
            |.....|..||:     .||..:.|:.
Mouse   126 KEKMLKVKIVKI-----HPLEKVDEEAVEKKSDGACDSPSSDKENSSQMAQDLQKKETVVKEDEG 185

  Fly   158 --DNLVYRLR-----------------------PNKGDPSAE------LDLPFRQLRRSRMEFNL 191
              :::..|.|                       |:|.|...:      .::|...|.|:....|.
Mouse   186 RRESINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNK 250

  Fly   192 ENLSMFIKSNVSRV-----------DGLLR--PKPEAYKQYVTDP-------------------- 223
            |.|..||:.|..|.           |.|::  ..|..:..::.||
Mouse   251 EILRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNPSTKRRNTGSPDR 315

  Fly   224 ----------------------------------------------------GV------NFSTI 230
                                                                ||      |.:.:
Mouse   316 KPSKKPKRDSSSLSSPLNPKLWCHVHLEKSLNGPPLKVKNSKNSKSPEEHLEGVMKIMSPNNNKL 380

  Fly   231 FIGKMPRYSPAKIKKPDGK------KQSTLNKYIVAGEATAAKSKA------------------- 270
            ....:|:..|| .||| ||      |.....|.|:.|:.:...||:
Mouse   381 HSFHIPKKGPA-AKKP-GKHSDKPLKAKGRGKGILNGQKSTGNSKSPSKCVKTPKTKMKQMTLLD 443

  Fly   271 -------------------------------------------KAKSDAKS-------------- 278
                                                       |.|.|.||
Mouse   444 MAKGTQKMTRTPRSSGGVPRSSGKPHKHLPPAALHLIAYYKENKDKEDKKSALSCVISKTARLLS 508

  Fly   279 ------LAEELERVKREKEAKLIE----------------LEKQKAEKKAQLIERV-ENECNLLL 320
                  |.||| |...:|..:|:|                |:|::.|.|.:|.|:. |.....:|
Mouse   509 NEDRARLPEEL-RALVQKRYELLEHKKRWASMSEEQRKEYLKKKRQELKERLREKAKERREREML 572

  Fly   321 QKTDDLER-TDQKV----LPRYRQIVTL--LPEHLLGDAFMMREFMHTYTGLLSGIEVFRQNLSF 378
            ::.:..:| .||::    ||.:|.:.|.  ||..|.||..::.||:..|:|||  :...:..::.
Mouse   573 ERLEKQKRFEDQELGGRNLPAFRLVDTPEGLPNTLFGDVALVVEFLSCYSGLL--LPDAQYPITA 635

  Fly   379 YEMTRALTAREIAG--PLSDILLVLLGTVFDLQKEEEEECAVTYLDRAAQTQEPYWSMAQAAKSH 441
            ..:..||:| :..|  .|:.:|::||.|:  ||.|..|:
Mouse   636 VSLMEALSA-DKGGFLYLNRVLVILLQTL--LQDEIAED-------------------------- 671

  Fly   442 LYAKRHFSFKVNELPLDALTLSEVLRLHLLGSGAFVNEKAERWRVMYRNGYSSKEDPGLELRLEH 506
             |.:  ...|::|:||...::||::||.|  ....|.|.:|.     .....:|:....|.....
Mouse   672 -YGE--LGMKLSEIPLTLHSVSELVRLCL--RRCDVQEDSEG-----SETDDNKDSTPFEDNEVQ 726

  Fly   507 SHILRILKNHSVYQLKFKDIMLLIRCLMSQI-MTYSGTINLIEERMEQTAKARQDLRALVVGENK 570
            ...|..|:....::|..::.:.::..|..:| |||| ..:.:|.|.:.:|:..::..|::..||.
Mouse   727 DEFLEKLETSEFFELTSEEKLRILTALCHRILMTYS-VQDHMETRQQVSAELWKERLAVLKEEND 790

  Fly   571 RLAAVEINRKKLTQMHHLEVNGVEPEKREALVEKL--KKSIAELHAQ------------------ 615
            :..|.:..||:      :|....|..|.|.::.|:  ||.|.::..|
Mouse   791 KKRAEKQKRKE------MEARNKENGKEENVLGKVDRKKEIVKIEQQVEVEADDMISAVKSRRLL 849

  Fly   616 SDQQHRKHELQ---------------MLKLH--------------SQLFNFLVYLGMDRCYRKYY 651
            |.|..||.|:|               .::.|              ::|......:|.||.:.:|:
Mouse   850 SMQAKRKREIQERETKVRLEREAEEERMRKHKAAAEKAFQEGIAKAKLVLRRTPIGTDRNHNRYW 914

  Fly   652 VLES-MPGIFVEHS--PDSLDTCLEQPITNKSQIEIRQQSALPKNRKDLRVYLLKLYGDDEKKTK 713
            :..: :||:|:|..  .:|:|...:.                  :|||..    .|..||.....
Mouse   915 LFSNEVPGLFIEKGWVHNSIDYRFKH------------------HRKDHS----NLPDDDYCPRS 957

  Fly   714 KKAKHSLENKENQEHRLNGSAEPMDVESDSPEAPTHFELLMCSGDKRSCIVHDSRNGQRQRWAYI 778
            |||........|..|   |.|    :|:.....|                    :.|| ..|...
Mouse   958 KKANLGKNASVNAHH---GPA----LEAVETTVP--------------------KQGQ-NLWFLC 994

  Fly   779 YKAEEIDELIKALNPNGLREYELLQELSVLRSLIEQHAKTCPVDLLSLENETMRKKFMAAMESET 843
            ...:|:|||:..|:|.|:||.:|                          .|.:.|::    :..|
Mouse   995 DSQKELDELLSCLHPQGIRESQL--------------------------KERLEKRY----QEIT 1029

  Fly   844 NRKY--GEANFGLPNGTDLNEVMRLHLVDRIIQFENDIYTGDLGRLKVKDMEKWRSDLLGGNYDA 906
            :..|  .:.|.|| ...|.|:        .::.|                   .||||:    :.
Mouse  1030 HSIYLARKPNLGL-KSCDGNQ--------ELLNF-------------------LRSDLI----EV 1062

  Fly   907 QCKLQWGPGGKLEDEAGSDNESHETHEEDDGALLGKYARKPYRDPGMYLAASADTKPLPDSDDEE 971
            ..:||.|..|.:|.          |.|                    :.|.....:.|.|
Mouse  1063 ATRLQKGGLGYMEG----------TSE--------------------FEARVISLEKLKD----- 1092

  Fly   972 DQHTNAVSIPIAVHNMASALLQVEQAIGKRFLKEPYGMKKWDPKQEALKLACD------------ 1024
                           ....::.::.::.|:||:   |...  |||:..||..:
Mouse  1093 ---------------FGECVIALQASVIKKFLQ---GFMA--PKQKKRKLQSEDSTKSEEVDEEK 1137

  Fly  1025 ---------SRLHQWEVSLMESTSFAQVFLHLNILHDCIQWRRSTNKSLCKVCRRGSDPEKMLLC 1080
                     |.|.:|:.::.|:.:|:::.:.|.:|..||:|..|...:.|||||:..:.:|::||
Mouse  1138 KMVEEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLILC 1202

  Fly  1081 DECNAGTHMFCLKPKLRSVPPGNWYCNDCVKSLGLSNGQNEKDKKQATKKKRKFIVEEEDDEATD 1145
            ||||...|:|||:|.|..||.|.|.|..|.......|.:.....:::|.:      ..|.||:.:
Mouse  1203 DECNKAFHLFCLRPALYEVPDGEWQCPACQPPTARRNSRGRNYTEESTSE------GSEGDESGE 1261

  Fly  1146 EEEEEKKDDDMTDEDAEHENEKHDEDVEDDESVTSTPSSSRVNGRILRRPRTRPTSRRLTSKEIE 1210
            |||||:            |.|:.:||.|             |.|   .|.|.|.|.|
Mouse  1262 EEEEEE------------EEEEEEEDYE-------------VAG---LRLRPRKTIR-------- 1290

  Fly  1211 EHAQEDVDSGDVSDDASLTAGEDTIEDESDEEKVCQKCFYDGGEIKCVQCRLFFHLECVHLKRPP 1275
                                |:.::                              :......|||
Mouse  1291 --------------------GKQSV------------------------------IPAARPGRPP 1305

  Fly  1276 RTDFVCKTCKPMPQRPRRRHSNMNGDHDRDEEEPKAKRPRNSLRLSIDKTARPSNGNNNNNNNNS 1340
                      .....|.||        .|.:::|:.    :.|.|...:.:|
Mouse  1306 ----------GKKSHPARR--------SRPKDDPEV----DDLVLQTKRISR------------- 1335

  Fly  1341 SVNNNNHRRSGRRTNEHMPLNSAALYDLLEQIMKHKAAWPFLRPVLTSEVPDYHQIIKTPMDLAK 1405
                   |:|         |......|:|.:::|::.:|||..||...|..||:.:|:.|||...
Mouse  1336 -------RQS---------LELQKCEDILHKLVKYRFSWPFREPVTRDEAEDYYDVIEHPMDFQT 1384

  Fly  1406 IKSKLNMGAYQLNEELLSDIQLVFRNCDLYNVEGNEIYDAGCQLERFVID------------RCR 1458
            |::|.:.|.|:..:|.|:|::.||.|.:|||..|:.:.....:.|:.::.            |.:
Mouse  1385 IQNKCSCGNYRSVQEFLTDMKQVFANAELYNCRGSHVLSCMEKTEQCLLALLQKHLPGHPYVRRK 1449

  Fly  1459 DMQLPFRPSDMNGE 1472
            ..:.|.|.:|..|:
Mouse  1450 RRKFPDRLADDEGD 1463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503	27/99 (27%)
		DDT	346..411	CDD:214726	20/66 (30%)
		WHIM1	505..554	CDD:292246	11/49 (22%)
		WHIM2	637..666	CDD:292247	8/31 (26%)
		WHIM3	775..813	CDD:292248	11/37 (30%)
		PHD_RSF1	1064..1109	CDD:277018	23/44 (52%)
		PHD	1244..1284	CDD:214584	3/39 (8%)
		Bromo_Acf1_like	1349..1463	CDD:99936	33/125 (26%)
Baz1b	NP_035844.2	WAC_Acf1_DNA_bd	21..120	CDD:287503	27/99 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..212		2/65 (3%)
		C motif	207..213		0/5 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..333		0/30 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..433		15/58 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..472		0/23 (0%)
		DDT	605..669	CDD:214726	21/68 (31%)
		WHIM1	725..770	CDD:292246	10/45 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	789..813		7/29 (24%)
		WHIM2	900..928	CDD:292247	8/27 (30%)
		WHIM3	991..1029	CDD:292248	13/67 (19%)
		PHD_BAZ1B	1186..1231	CDD:277098	23/44 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1231..1324		32/206 (16%)
		Bromo_WSTF_like	1340..1436	CDD:99937	30/95 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1451..1479		4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810