DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acf and Baz1a

DIOPT Version :9

Sequence 1:	NP_536734.2	Gene:	Acf / 43751	FlyBaseID:	FBgn0027620	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	NP_038843.2	Gene:	Baz1a / 217578	MGIID:	1309478	Length:	1552	Species:	Mus musculus

Alignment Length:	1688	Identity:	427/1688 - (25%)
Similarity:	723/1688 - (42%)	Gaps:	367/1688 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPICKREGFDLNQKEGKNETFHDNDQVFCCYITKRIFRDYEHYFRHVMVINSTVWQCEATGKENL 65
            ||:..|:.|...:..|   ....:::||.|.:|..|||.|:.:|...::.||.||.|..||:..|
Mouse     1 MPLLHRKPFVRQKPPG---DLRPDEEVFYCKVTNEIFRHYDDFFERTILCNSLVWSCAVTGRPGL 62

  Fly    66 TYEEAVKSERAARKKMEQFKQSLRAPVLLVVEHAQQSAVNTLNMIVAKFLRKRYFIGEEVSVQAK 130
            ||:||::|||.||:.::.|.:.|..|||.:....::|.::.:...:..:::.|||:.|.|.| .:
Mouse    63 TYQEALESERKARQNLQSFPEPLIIPVLYLTNLTRRSRLHEICDDIFAYVKDRYFVEETVEV-IR 126

  Fly   131 KNATYTVLGVKLDKNMPEPL------NG----------IYEDTDN-------------------- 159
            .|.|.  |..::.:.:| ||      ||          :..|:|:
Mouse   127 NNGTR--LQCRILEVLP-PLHQNGFANGHLSSADGETIVISDSDDSETQSSSFHHGKKKDAIDPL 188

  Fly   160 -LVYRLRPNKGDPSAELDLPFRQLRRSRMEFNLENLSMFIKSNVSRVDGLLRPKPEAYKQY-VTD 222
             ..||::|.|.:......:...|:.|.:..|:.:.|.:|:|.:....||:::.|..::..| :.:
Mouse   189 LFRYRVQPTKKEMYESAVVKATQISRRKHLFSRDKLKLFLKQHCEAQDGVIKIKASSFSAYNIAE 253

  Fly   223 PGVNFSTIFIGKMPR--YSPAKIKKPDGKKQSTLNKY-IVAGEATAAKSKAKAKSDAKSL----- 279
            .  :||..|....|.  :|||..::....|:.:..:. .:|.:.|||:.:.||..:...|
Mouse   254 Q--DFSYFFPDDPPTFIFSPANRRRGRPPKRISFGQEDSIASKQTAARYRNKAIKERDKLLKQEE 316

  Fly   280 ---------------AEELERVKREKE---------AKLIELE--KQKAEKKAQLIERVENECNL 318
                           |:.||..|||||         .|::|.|  |:|.||:...|||.:....|
Mouse   317 MRALAFEKAKLKRERADALEARKREKEDKEKKREELKKMVEEERLKKKEEKERLKIEREKEREKL 381

  Fly   319 LLQK-------------TDDLERTDQKVLPRYRQIVTLLPEHLLGDAFMMREFMHTYTGLLSGIE 370
            ..:|             .:|:|..|.|.||....:.|.||..:.|||.|:.||::.:..|....:
Mouse   382 REEKRKYMEYLKQWSKPREDMECDDLKELPEPTPVKTRLPPEVFGDALMVLEFLNAFGELFDLQD 446

  Fly   371 VFRQNLSFYEMTRALTAREIAGPLSDILLVLLGTVFDLQKEEEEECA---VTYLDRAAQTQ---- 428
            .|.:.::...:..||...:..|||.::|...|..:|....|||||.|   :|..|....|:
Mouse   447 EFPEGVTLEVLEEALVGNDSEGPLCELLFFFLTAIFQAMAEEEEEVAKEQITDADTKDLTEALDE 511

  Fly   429 --EPYWS--MAQAAKSHLYAKRHFSFKVNELPLDALTLSEVLRLHLLGSGAFVNEKAERWRVMYR 489
              :|..|  .|.||.:..:.:.|....:..|.||:.||||:||||:|.|||.|.....::|...|
Mouse   512 DADPTKSALSAVAALAAAWPQLHQGCSLKSLDLDSCTLSEILRLHILASGADVTSANAKYRYQKR 576

  Fly   490 NGYSSKEDPGLELRLEHSHILRILKNHSVYQLKFKDIMLLIRCLMSQIMTYSGTINLIEERMEQT 554
            .|:.:.:|..:||||.:..:::.|.:.|||.|...:.|.::..|..:::|...|.:.||:.::..
Mouse   577 GGFDATDDACMELRLSNPSLVKKLSSTSVYDLTPGEKMKILHALCGKLLTLVSTRDFIEDYVDVL 641

  Fly   555 AKARQDLRALVVGENKR---LAAVEINRKK----------------------------------- 581
            .:|:|:.|.|...::::   ..|..|.|:|
Mouse   642 RQAKQEFRELKAEQHRKEREATAARIRRRKEEKLKEQEQKMKEKQEKLKEDEQRNSAAVPGEEER 706

  Fly   582 -----LTQMHHLEVNGVEPE-----------------------------KREALVEKLKK----S 608
                 .|:..::|...::|:                             |:|.:...:|:    :
Mouse   707 EDFDTSTENKNIEQKDLDPDVVTEDEDDPGSHKRSRRGKVGQTAVKQCIKQEEMNYCIKQEPLSA 771

  Fly   609 IAELHAQSDQQHRKHELQMLKLHSQLFNFLVY-LGMDRCYRKYYVLESMPGIFVEHSPDSL--DT 670
            .||...:.:||.::.|| :.|:.|.:....:: ||.||.||:|::..|:||:|:|.....|  |.
Mouse   772 DAEEALRQEQQQKEKEL-LDKIQSAIACTNIFPLGRDRLYRRYWIFPSIPGLFIEEDYSGLTEDM 835

  Fly   671 CLEQPIT--NKSQIEIRQQSALPKNRKDLRVYLLKLYGDDEKKTKKKAKHSLENKENQEHRLNGS 733
            .|.:|.:  |.:|            .:|.:|.:                      :.:|..|:.|
Mouse   836 LLPRPSSFHNNAQ------------PRDPQVSI----------------------KTEESFLSES 866

  Fly   734 AEPMDVESDSPEAPTHFELLMCSGDKRSCIVHDSRNGQRQRWAYIYKAEEIDELIKALNPNGLRE 798
            ...:|      :.|....:|:...      ||     :..||.:.....::|:||.|||..|.||
Mouse   867 TSSLD------QGPFDDSVLLPKP------VH-----KPNRWCFYSSCAQLDQLIDALNSRGHRE 914

  Fly   799 YELLQELSVLRSLIEQHAKTCPVDLLSLENETMRKKFMAAMESETNRKYGEANFGLPNGTDLNEV 863
            ..|.:      :|:::.::.| ..|.....|    ||..:.:.:.:.|...:........|::::
Mouse   915 SALKE------TLLQEKSRIC-AQLAHFSEE----KFHFSDKPQADSKPVSSRGRSSGACDISQM 968

  Fly   864 -----MRLHLVDRIIQFENDIYTGDLGRLKVKDMEKWRSDLLGGNYDAQCKLQWGPGGKLEDEAG 923
                 :.|.|.|.::..|:.||.|.||.:||.|.:.|||.|..|.|:            |..|..
Mouse   969 SAERQLELRLRDFLLDIEDRIYQGTLGAIKVTDRQVWRSALENGRYE------------LLSEES 1021

  Fly   924 SDNESHETHEEDDGALLGKYARKPYRDPGMYLAASADTKPLPDSDDEEDQHTNAVSIPIAVHNMA 988
            .:|...:|..||...:..:.||...||  ..|....:|.....:.....|     |:...||.:|
Mouse  1022 KENGVIKTVNEDVEEMEMEQARVIVRD--RLLGIKTETPSTISTSASTPQ-----SVSNVVHYLA 1079

  Fly   989 SALLQVEQAIGKRFLKEPYGMKKWDPKQEALKLACDSRLHQWEVSLMESTSFAQVFLHLNILHDC 1053
            .||.|:||.|.:||||.|.   ..:....:.|...|    :|..||:.|.|.:||||||:.|...
Mouse  1080 LALFQIEQGIERRFLKAPL---DGNDSGRSYKTVLD----RWRESLLSSASLSQVFLHLSTLDRS 1137

  Fly  1054 IQWRRSTNKSLCKVCRRGSDPEKMLLCDECNAGTHMFCLKPKLRSVPPGNWYCNDCVKSLGLSNG 1118
            :.|.:|...:.||:||:..|.|.|:|||.|:.|.|.:|::|||::||.|:|:|.:|        .
Mouse  1138 VMWSKSILNARCKICRKKGDAENMVLCDGCDRGHHTYCVRPKLKAVPDGDWFCPEC--------R 1194

  Fly  1119 QNEKDKKQATKKKRKFIVEEEDDEATDEEEEEKKDDDM--TDEDAEHENEKHDEDVEDDESVTST 1181
            ..::.::.:::::.....:||.:|..:::::|..|||.  ..|:.|:|.|:.:||.:|||:: |.
Mouse  1195 PKQRSRRLSSRQRPSLESDEEMEEGMEDDDDEVDDDDEEGQSEEEEYEVEQDEEDSDDDEAL-SP 1258

  Fly  1182 PSSSRVNGRI-------------LRRPRTRP-----TSRRLTSKEIEEHAQEDV---DSGDVSDD 1225
            |...|...|:             .|..|..|     .|::.|.|...:.|.:::   .|...::.
Mouse  1259 PKRGRPQVRLPIKTKGRFGPSFPSRSQRQDPGRYPSRSQQSTPKNTAKSASKNLRKTRSAPPTET 1323

  Fly  1226 ASLTAGEDTIEDESDEEKVCQKCFYDGGEIKCVQCRLFFHLECVHLKR-------------PPRT 1277
            .||..|       |...:.......|          :|..|...|.||             |..|
Mouse  1324 RSLRVG-------SRSTRHSPSALQD----------VFVELLSPHSKRRGRKGADHTPEHSPSFT 1371

  Fly  1278 DFVCKTCKPMPQRPRRRHSNMNGDHDRDEEEPKAKRPRNSLRLSIDKTARPSNGNNNNNNNNSSV 1342
            :|...|     .|..|:...:|.......:..::|| |...|.|.:.:..|.
Mouse  1372 NFRVST-----SRSSRQLIPLNTAESLSLQHSESKR-RGRKRQSTESSPVPL------------- 1417

  Fly  1343 NNNNHRRSGRRTNEHMPLNSAALYDLLEQIMKHKAAWPFLRPVLTSEVPDYHQIIKTPMDLAKIK 1407
               |.|.|||:...|   ..:|...|:.::::|..:||||:.|...:||||:.|||.|:.|..|:
Mouse  1418 ---NRRSSGRQGGVH---ELSAFEQLVVELVRHDDSWPFLKLVSKIQVPDYYDIIKKPIALNIIR 1476

  Fly  1408 SKLNMGAYQLNEELLSDIQLVFRNCDLYNVEGNEIYDAGCQLERFVIDRCRDMQLPFRPSDMN 1470
            .|:|...|:|..|.:.||:|:|.||..||........||.:|:.|...:.:.:.|...||.::
Mouse  1477 EKVNKCEYKLASEFIDDIELMFSNCFEYNPRNTSEAKAGTRLQAFFHIQAQKLGLHVSPSTVD 1539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503	36/98 (37%)
		DDT	346..411	CDD:214726	16/64 (25%)
		WHIM1	505..554	CDD:292246	11/48 (23%)
		WHIM2	637..666	CDD:292247	12/29 (41%)
		WHIM3	775..813	CDD:292248	12/37 (32%)
		PHD_RSF1	1064..1109	CDD:277018	22/44 (50%)
		PHD	1244..1284	CDD:214584	9/52 (17%)
		Bromo_Acf1_like	1349..1463	CDD:99936	39/113 (35%)
Baz1a	NP_038843.2	Required for interaction with NCOR1. /evidence=ECO:0000250	1..133		45/137 (33%)
		Required for association with the CHRAC1/POLE3 complex. /evidence=ECO:0000250	1..128		43/130 (33%)
		WAC_Acf1_DNA_bd	23..122	CDD:371121	36/98 (37%)
		DDT	423..483	CDD:367184	15/59 (25%)
		WHIM1	591..635	CDD:373966	10/43 (23%)
		PTZ00121	<643..>795	CDD:173412	21/152 (14%)
		WSD	799..925	CDD:373967	41/182 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	840..871		8/64 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..966		2/24 (8%)
		PHD_BAZ1A	1148..1193	CDD:277097	22/44 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1200..1426		56/265 (21%)
		APC_basic	1255..>1437	CDD:368684	42/224 (19%)
		Bromo_Acf1_like	1418..1531	CDD:99936	41/115 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848855
Domainoid	1	1.000	84	1.000	Domainoid score	I8310
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	427	1.000	Inparanoid score	I1732
Isobase	1	0.950	-	0	Normalized mean entropy	S5503
OMA	1	1.010	-	-		QHG45550
OrthoDB	1	1.010	-	-		D858930at2759
OrthoFinder	1	1.000	-	-		FOG0005585
OrthoInspector	1	1.000	-	-		oto93738
orthoMCL	1	0.900	-	-		OOG6_107600
Panther	1	1.100	-	-	LDO	PTHR46510
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4315
SonicParanoid	1	1.000	-	-		X4556
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.890