DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acf and baz-2

DIOPT Version :9

Sequence 1:	NP_536734.2	Gene:	Acf / 43751	FlyBaseID:	FBgn0027620	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	NP_498673.3	Gene:	baz-2 / 176078	WormBaseID:	WBGene00001470	Length:	1390	Species:	Caenorhabditis elegans

Alignment Length:	1561	Identity:	297/1561 - (19%)
Similarity:	520/1561 - (33%)	Gaps:	544/1561 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VINSTVWQCEATGKENLTYEEAVKSERAARKKMEQFKQSLRAPVLLVVEHAQQSAVNTLNMIVAK 113
            ::|:.:||..|...:    ::..:.::..:||.:|.|   :|..|...:..:|...|.....:.|
Worm   220 MMNNVMWQLVAAQMQ----QKQQQQQKDTQKKADQAK---KAKELAKQQQKEQDVKNKQQEEILK 277

  Fly   114 FLRKRYFIGEEVSVQAKKNATYTVLGVK--------LDKNMPEPLNGIYEDTDNLVYRLRPNKGD 170
            ||..::.:..: ....||.|....|..|        |:.:.||                 ..|..
Worm   278 FLMAQHQLNHQ-KKHEKKQADAAALAAKVLAAHRAALESDSPE-----------------EGKKT 324

  Fly   171 PSAELDLPFRQLRRSRMEFNLENLSMFIKSNVSRVDGLLRP---KPEAYKQ-----------YVT 221
            ..|.|.||. ||...|........|..:|.:||    ...|   |...|.:           |:|
Worm   325 NEAMLRLPL-QLGWRRQTCVRSIASAGVKGDVS----YFAPCGKKLSTYSEVVRYLTKNSIHYIT 384

  Fly   222 DPGVNFST-IFIGK--MPRYSPAKIKKPDGK----KQSTLNKYIVAGEATAAKSKAKAKSDAKSL 279
            .....|:| :.||:  :|:.:.|...:.:.:    .:..:||.:..........|.:|.:.....
Worm   385 RDNFLFNTKLVIGEFIVPKQTEADETQQEREFAMFTEDDINKELTRLNVLKFVPKIQASTSNGVH 449

  Fly   280 AEELERVKREKEAKLI---ELEKQKAEK--KAQLIERVENECNLLLQKTDDL--ERTDQKVLPRY 337
            .::::..|.|:..:.:   ||..:..|:  .:|::....:||.:..::.|||  ...|.:.||.:
Worm   450 EDDIKMSKIEEPDEPLDPSELNDEFTEELVHSQIMSNGVDECKIREREADDLLVNINDVRHLPDF 514

  Fly   338 RQIVT-LLPEHLLGDAFMMREFMHTYTGLLSGIEVFRQNLSFYEMTRALTAREIAGPLSDILLVL 401
            .:|.. .|......||.|:.||:..: |.:.||::                 |||..|..:...|
Worm   515 SRIGNQCLSSQGFADALMVHEFVQNF-GHVLGIDL-----------------EIAPKLESLCAGL 561

  Fly   402 LGTVFDLQKEEEEECAVTYLDRAAQTQEPYWSMAQAAKSH--LYAKRHFSFKVNELPLDALTLSE 464
            .|..                :.|.||.:....:.:.|...  :..::.|.....|:.||....||
Worm   562 DGDA----------------NHAEQTLQLTRQLLRLALEFPGMGNEKRFGQGGGEMGLDRENFSE 610

  Fly   465 VLRLHLLGSGAFVNEKAERWRVMYRNGYSSKEDPGLELRLEHSHILRILKNHSVYQLKFK-DIML 528
            |:||.|:..|                    |....|...|...:.|.|........|.|. |.::
Worm   611 VMRLFLIDKG--------------------KRGEELSQPLLTCNFLSISPEQKASILAFLCDELV 655

  Fly   529 LIRCLMSQIMTYSGTINLIE-ERMEQTAKAR----------QDLRALVVGENKR----------- 571
            ..|.::::|......|:.:: |:..:..|||          .|.:.:||.|.:.
Worm   656 CSRNVVTEIDKNLDEISRLKGEKWMREGKARALRSARSKKKNDEKVVVVKEEQNHESDSEPPTRP 720

  Fly   572 ------------------LAAVEINRKKLTQ-MHHLEVNGVEPEKREAL-VEKLKKSIAELHAQS 616
                              ::|.:..::|.|. :...|   |..|:.|:: ::::...|.:||.::
Worm   721 DTPKKATVAPPTVVSVSPVSAAQQQQRKFTPGLGQCE---VLTEQEESMSLQQMDSLIGDLHQEA 782

  Fly   617 DQQHRKHELQMLKLHSQLFNFLVYLGMDRCYRKYYVLESMPGIFVEHSPDSL-DTCLEQPITNKS 680
            ...::|.....||:.|  |.|    |.||.:|.|::|.....:.:|    || .|.:..|..|.:
Worm   783 QNINQKIHDTGLKIRS--FPF----GTDRFHRNYWMLAHTDKVIIE----SLATTSVNNPACNAN 837

  Fly   681 QIEIRQQSALPKNRKDLRVYLLKLYGDDEKKTKKKAKHSLENKENQEHRLNGSAEPMDVESDSPE 745
            :...:....|                                    |.|:.|:.|.:|:
Worm   838 EYASKDPPTL------------------------------------EQRVPGACETIDL------ 860

  Fly   746 APTHFELLMCSGDKRSCIV-----HDSRNGQRQR---------WAYIYKAEEIDELIKALNPNGL 796
                 :::.|..|....:|     .|.:..:|.|         |..:...:.::.|...:...|:
Worm   861 -----DVIACVEDLVDDVVLLRAKADKKTRKRYRRIENHMKRGWWTMQNRDCVESLRSCMLSRGI 920

  Fly   797 REYEL---------LQELSVLRSLIEQHAKTCPVDLLSLENETMRKKFMAAMESETNRKYGEANF 852
            ||..|         |.||......||...:...::|:                    |:.|
Worm   921 RERALHRLLTKPWFLNELKFGTITIEPVGEKSDLELV--------------------RRQG---- 961

  Fly   853 GLPNGTDLNEVMRLHLVDRIIQFENDIYTGDLGRLKVKDMEKWRSDLLGGNYDAQCKLQWGPGGK 917
                .|.||..     :|::                                  ||.|      |
Worm   962 ----WTRLNTA-----IDKL----------------------------------QCHL------K 977

  Fly   918 LEDEAGSDNESHETHEEDDGALLGKYARKPYRDPGMYLAASADTKPLPDSDDEEDQHTNAVSIP- 981
            :.|.                                       :||||.....|.|  ..:.:|
Worm   978 MSDV---------------------------------------SKPLPSITPFETQ--KPIVVPP 1001

  Fly   982 ------IAVHNMASALL-------QVEQAIGKRFLKEPYGM---KKWDPKQEALKLACDSRLHQ- 1029
                  |...:||..::       ::::.|.::.:.|...|   |.|.||.:.|:.....:|.:
Worm  1002 TMALAQIVKDDMAWKVIDEEVDGQELDETIIRQKIIETADMVQPKFWRPKFQKLEDQDTCQLFED 1066

  Fly  1030 WE--VSLMESTSFAQVFLHLNILHDCIQWRRSTNKSLCKVCRRGSDPEKMLLCDECNAGTHMFCL 1092
            |:  || .|:.:.:|:.:.|..|...|.|.||:.::||::| :..|.::||:||.|.:|.||.|.
Worm  1067 WKSYVS-TEAQTTSQLMVALQTLEGMIMWERSSREALCQIC-KSMDGDEMLVCDGCESGCHMECF 1129

  Fly  1093 KPKLRSVPPGNWYCNDCVKSLGLSNGQNEKDKKQATKKKRKFIVEEEDDEATDEEEEEKKDDDMT 1157
            :|::..||.|:|:|..|                                      .|||
Worm  1130 RPRMTKVPEGDWFCQRC--------------------------------------REEK------ 1150

  Fly  1158 DEDAEHENEKHDEDVEDDESVTSTPSSSRVNGRILRRPRTRPTSRRLTSKEIEEHAQEDVDSGDV 1222
                                          :||
Worm  1151 ------------------------------SGR-------------------------------- 1153

  Fly  1223 SDDASLTAGEDTIEDESDEEKVCQKCFYDGGEI-KCVQCRLFFHLECVHLKRP-----PRTDFVC 1281
                                .:|..|..:.|.: :|.:|....|.||.. ..|     |.| |:|
Worm  1154 --------------------PMCMFCSRETGNLHQCQRCAYHVHQECSQ-DGPKEAINPET-FIC 1196

  Fly  1282 KTCKPMPQ-RPRRRHSNMNGDHDRD-EEEPKAKRPRNSLRLSIDKTARPSNGNNNNNNNNSSV-- 1342
            ..|:.|.| |..:|....:...:|: |::..|:...|:           .||:.|..|...::
Worm  1197 GHCQEMKQMRFVKRLILRSESEERELEDDNHAENGENT-----------KNGHMNGMNGAIAIGV 1250

  Fly  1343 -NNNNHRRSGRRTNEHMP--------LNSAALYDLLEQIMKHKAAWPFLRPVLTSEVPDYHQIIK 1398
             |..|..:...:....:|        :|......:|::::....|.|||.||....||.|..||.
Worm  1251 HNQQNGVKGNLKRKLEVPSIGGLPKNMNKELCQLMLDELVVQANALPFLEPVNPKLVPGYKMIIS 1315

  Fly  1399 TPMDLAKIKSKLNMGAYQLNEELLSDIQLVFRNCDLYNVEGNEIYDAGCQLERFVIDRCRDMQLP 1463
            .||||..|:.|.....|:..|:...||:|:|.||..:|::.:||..||..|.:|...|.:.::..
Worm  1316 KPMDLKTIRQKNEKLIYETPEDFAEDIELMFANCRQFNIDHSEIGRAGISLHKFFQKRWKQLKYN 1380

  Fly  1464 F 1464
            |
Worm  1381 F 1381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503	15/75 (20%)
		DDT	346..411	CDD:214726	14/64 (22%)
		WHIM1	505..554	CDD:292246	9/50 (18%)
		WHIM2	637..666	CDD:292247	8/28 (29%)
		WHIM3	775..813	CDD:292248	9/46 (20%)
		PHD_RSF1	1064..1109	CDD:277018	19/44 (43%)
		PHD	1244..1284	CDD:214584	13/45 (29%)
		Bromo_Acf1_like	1349..1463	CDD:99936	36/121 (30%)
baz-2	NP_498673.3	FlgD	35..88	CDD:281896
		HAT_MBD	328..401	CDD:238691	19/77 (25%)
		DDT	524..>564	CDD:295426	13/57 (23%)
		WHIM1	622..670	CDD:292246	9/47 (19%)
		WHIM3	899..931	CDD:292248	6/31 (19%)
		PHD_BAZ2A_like	1102..1146	CDD:277020	19/44 (43%)
		PHD	1155..1199	CDD:214584	13/45 (29%)
		Bromo_BAZ2A_B_like	1278..1374	CDD:99935	34/95 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158371
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830