Protein Alignment Acf and athp-2

DIOPT Version :10

• Sequence 1: NP_536734.2
• Gene: Acf / 43751
• FlyBaseID: FBgn0027620
• Length: 1476
• Species: Drosophila melanogaster
• Sequence 2: NP_494767.2
• Gene: athp-2 / 173769
• WormBaseID: WBGene00019217
• Length: 1412
• Species: Caenorhabditis elegans
• Alignment Length: 1659
• Identity: 375/1659 - (22%)
• Similarity: 642/1659 - (38%)
• Gaps: 457/1659 - (27%)

  Fly     1 MPICKREGFDLNQKEGKNETFHDNDQVFCCYITKRIFRDYEHYFRHVMVINSTVWQCEATGKENL 65
            ||:..::.|   :.:...:....:..||.|..||.:|..:|.||..::::|||.|.|..|.|.||
 Worm     1 MPLLHKQQF---EPQSVPDGVTRDTPVFYCKATKEVFLTHEEYFNRMILLNSTAWSCSLTRKSNL 62

  Fly    66 TYEEAVKSERAARKKMEQFKQSLRAPVLLVV-EHAQQSAVNTLNMIVAKFLRKRYFIGEEVSVQA 129
            ||.||:.|||.|.:::..|..:|..|:.|:| ::..:.....|...:...|:.|:|..|||: .|
 Worm    63 TYFEAIASEREAEQELCNFPTALEIPITLIVHKYTNRGRFEDLVNDIYHILKDRFFNNEEVA-YA 126

  Fly   130 KKNATYTVLGVKLDKNMPEPLNGIYEDTDNLVYRLRPNKG---------DPSAELD------LPF 179
            :|:..:  |...::.|..|..|..:|....|...:.|...         ||:...:      :.|
 Worm   127 EKSRKF--LAKIVESNQIEEQNPSFEGGSELKEPILPPPDTFRYTLQILDPAVSEEEMYREGIAF 189

  Fly   180 RQLRRSRMEFNLENLSMFIKSNVSRVDGLLRPKPEAY-----------KQYVTD----------- 222
            .:|.||:...:.:.:.:|:|:...     :.|..|.|           ..|.||
 Worm   190 DRLFRSKNIGSRQKIRLFLKNCCQ-----MSPDSERYTLKFQFLEKIDNLYWTDVMSGAEPICPQ 249

  Fly   223 -PGVNF----STIFIG------KMPR---YSPAKIKKPDG------------KKQSTLNKYIVAG 261
             |.:..    :|:..|      |.|:   ..||...:|.|            ||:..:.|...||
 Worm   250 TPALQRGRAPNTLKAGDHERKEKKPKKEERDPAAPPRPRGRPPKTPEQKALDKKEKQMRKRAEAG 314

  Fly   262 E---------------------ATAAKSKAKAKS------------------------------- 274
            .                     .:.||.|.:.:|
 Worm   315 REAPKPDDFDLTSSGAMTLSIPVSPAKKKIRRESGSSMSGKKKTKILEQQGELCFFFSEARRLGI 379

  Fly   275 ------------DAKSLAEELERVKREKEAKLIELEKQKAEKKAQLIERVENECNLLLQKTDDLE 327
                        ..|::|:..:|||.||:|   |.|:.|.|||.::.|:....     :|.:||.
 Worm   380 DVGGLEQEEKLLSGKAVADFKQRVKEEKDA---EKERAKEEKKRKMREKTAYN-----KKREDLI 436

  Fly   328 RTDQKVLPRYRQIVTLLPEHL----LGDAFMMREFMHTYTGLLSGIEV-FRQNLSFYEMTRALTA 387
            ..|.|.|||:.::.  :||.:    ..|...:.:|.:::..||...|: ....:.|.::..|:..
 Worm   437 CNDLKPLPRFPKLE--IPEWISNAEFEDYLFIFQFFNSFKQLLPLKEIRGSDEVQFSDIIIAIKC 499

  Fly   388 REIA-GPLSDILLVLLGTVFDLQKEEE-EECAVTYLDRA----AQTQEPYW-----SMAQAAKSH 441
            .:.. ...:|:|.|||....|:..||: :|..:...:..    ||..:|..     |:...:..|
 Worm   500 NDPQNSSFADLLRVLLSIRTDIADEEDGDEADINNREEVYLINAQNCDPAHVTHGDSIRDLSDLH 564

  Fly   442 LYAKRHFSFKVNELPLDALTLSEVLRLHLLGSGAFVNEKAERWRVMYRNGYSSKEDPGLELRLEH 506
            ...::.....|..||:|.:||:|||||....||.:......|.|:..|..:...|||..|.|..|
 Worm   565 FKIRKIHGKSVRHLPVDWMTLTEVLRLIFETSGYYTGMATHRHRLYARGNFRGYEDPAYEFRTRH 629

  Fly   507 SHILRILKNHSVYQLKFKDIMLLIRCLMSQIMTYSGTINLIEERMEQTAKARQD---LRALVVGE 568
            ..|:..|:..:|:.|:..:.:.:::.|:.|::|||.....:|:|..:..:.:::   |:|..||:
 Worm   630 PGIMEKLRTLTVFDLEAPERLEIVKTLIYQLLTYSKFRGHLEQRQNELVELKREQKKLKAWDVGQ 694

  Fly   569 NKRLAAVEINRKKLTQMHHLEVNG---VEPEKREALVEKLKK----------------------- 607
            .....|..:    |.::.....:|   |:.:|...:|.:||.
 Worm   695 EGEANAARL----LLELAPAGASGAPDVKEQKEPPVVRRLKAHIKAINEGRRYDKEDLDAIVLES 755

  Fly   608 ------SIAELHAQSDQQHRKHELQMLKLHSQLFNFL-----VYLGMDRCYRKYYVLESMPGIFV 661
                  |:.|:....:.|..:.::.|..|.|::|...     :.||.||.||:|.|:|::..|.|
 Worm   756 VPYASLSLDEIVTARELQKSEFKILMDSLISKMFQIYSKISDIRLGSDRAYRRYIVMENLSAILV 820

  Fly   662 EHSPDSLDTCLEQPITNKSQIEIRQQSALPKNRKDLRVYLLKLYGDDEKKTKKKAKHSLENKENQ 726
            |.:                            ..::|.:|.      ||........:.|||:
 Worm   821 ETA----------------------------TFQELGIYC------DEPSIIDDPLNLLENE--- 848

  Fly   727 EHRLNGSAEPMDVESDSPEAPTHFELLMCSGDKRSCIVHDSRNGQRQRWAYIYKAEEIDELIKAL 791
                                  |.|:.:|:|:..:|.||...:....||:||...|:.::|:|:|
 Worm   849 ----------------------HQEVFICTGNMDTCRVHGDESNNWTRWSYIRDREQFEQLLKSL 891

  Fly   792 NPNGLREYELLQELSVLR-SLIEQHAKTCPVDLLSLENETMRKKFMAAMESETNRKYGEANFGLP 855
            ||.|.||.|||:||:..| ||:|...:|..:.....:.:..:.:||      ||    :.|.|..
 Worm   892 NPRGNREVELLEELNEYRPSLLEILEETERLHEEEEDEDEWKSQFM------TN----DPNPGDT 946

  Fly   856 NGTDLNEVMRLHLVDRIIQFENDIYTGDLGRLKVKDME----KWRSDLL-GGNYDAQCKLQWGPG 915
            ...|.:..||    |.::.||..|..|.:|.:: |..|    :||.:|. .||.   |.|.
 Worm   947 YNIDWDAEMR----DLLLDFEEKIDQGQMGSIE-KIFECNRIEWRDNLKESGNV---CMLL---- 999

  Fly   916 GKLEDEAGSDNESHETHEEDDGALLGKYARKPYRDPGMYLAASADTKPLPDSDDEEDQHTNAVSI 980
                              .:|.::.|:.:                      .:.||.:|.:. |:
 Worm  1000 ------------------NEDISIFGEIS----------------------VNLEESEHFSD-SM 1023

  Fly   981 PIAVHNMASALLQVEQAIGKRFLKEPYGMKKWDPKQEALKLACDSRLHQWEVSLMESTSFAQVFL 1045
            .:|:     |...:.::|..:|:|.||....   |.|...|.......:|:.:|:|..|.:.:.|
 Worm  1024 KLAI-----AFYMIIKSIHLKFIKAPYISPN---KDEHGNLKPSELFIRWQRALLECESHSALSL 1080

  Fly  1046 HLNILHDCIQWRRSTNKSLCKVCRRGSDPEKMLLCDECNAGTHMFCLKPKLRSVPPGNWYCNDCV 1110
            .::.....|:|.:|..:..|:.|||.:....::||.||:...|:.|.|..:.|..|.:|.|..|
 Worm  1081 FISTFEGSIKWDKSRLQGKCRSCRRKAAAHDLVLCSECDNCYHLKCAKLDVNSDAPADWMCTSC- 1144

  Fly  1111 KSLGLSNGQNEKDKKQATKKKRKFIVEEEDDEATDEEEEEKKDDDMTDEDAEHENEKHDEDVEDD 1175
                  ..|..|.:.:|.:..|     ::|..|....:|:....:::..|  :.:|...:..|..
 Worm  1145 ------RAQQRKVENEAKRMAR-----DDDQLAESSSQEDVAIGNISISD--NFSEIAPKTAEPA 1196

  Fly  1176 ESVTSTPSSSRVNGRILRRPRTRPTSRRLTSKEIEEHAQEDVDSGDVSDDASLTAGEDTIEDESD 1240
            || .|||::|       :.|   ||.|..:.:.::.....|:..|
 Worm  1197 ES-CSTPTTS-------KEP---PTIRTASGRAVKRVHYSDIHEG-------------------- 1230

  Fly  1241 EEKVCQKCFYDGGEIKCVQCRLFFHLECVHLKRPPRTDFVCKTCKPMPQRPRRR----------- 1294
                                        :.||..       |:...||..|..|
 Worm  1231 ----------------------------LSLKNR-------KSNGSMPVTPSERPVRNVSVRIFD 1260

  Fly  1295 --HSNMNGDHDRDEEEPKAKRPRNSLRLSIDKTARPSNGNNNNNNNNSSVNNNNHRRSGRRTNEH 1357
              :.|:..|.|..:.|...||...:.:.|:  |:.|:      .|:.|.|...|       ..|.
 Worm  1261 VENENVLTDEDDSDGENTRKRKTPTSKKSV--TSTPT------TNDISRVIIPN-------IKEK 1310

  Fly  1358 MPLNSAALYDLLEQIMKHKAAWPFLRPVLTSEVPDYHQIIKTPMDLAKIKSKLNMGAYQLNEELL 1422
            |.|    :..||::.|:.:.:||||:||.:.|||||:.:||.||:|..:.:|:....|....|:.
 Worm  1311 MTL----IETLLKEAMRQECSWPFLQPVDSKEVPDYYDVIKRPMNLRTMMNKIKQRIYNKPIEVR 1371

  Fly  1423 SDIQLVFRNCDLYNVEGNEIYDAGCQLERFVIDR 1456
            :|.||:..||:.||...||||....:|..|:.||
 Worm  1372 NDFQLILSNCETYNEPENEIYKLSRELHDFMADR 1405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:463140	36/99 (36%)
		DDT	346..411	CDD:214726	14/70 (20%)
		WSD	641..>666	CDD:464775	12/24 (50%)
		WSD	<774..805	CDD:464775	16/30 (53%)
		PHD_RSF1	1064..1109	CDD:277018	15/44 (34%)
		PHD	1244..1284	CDD:214584	3/39 (8%)
		Bromo_Acf1_like	1349..1463	CDD:99936	40/108 (37%)
athp-2	NP_494767.2	WAC_Acf1_DNA_bd	23..123	CDD:463140	36/99 (36%)
		DDT	457..524	CDD:214726	13/66 (20%)
		WHIM1	629..671	CDD:464774	10/41 (24%)
		WSD	795..897	CDD:464775	37/160 (23%)
		PHD	1100..1144	CDD:214584	15/43 (35%)
		BROMO	1306..1409	CDD:197636	41/111 (37%)