DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acf and CREBBP

DIOPT Version :9

Sequence 1:	NP_536734.2	Gene:	Acf / 43751	FlyBaseID:	FBgn0027620	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	NP_004371.2	Gene:	CREBBP / 1387	HGNCID:	2348	Length:	2442	Species:	Homo sapiens

Alignment Length:	285	Identity:	60/285 - (21%)
Similarity:	108/285 - (37%)	Gaps:	65/285 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1177 SVTSTPSSSRVNGRILRRPRTRPTSRRLTS-----------KEIEEHAQEDVDSGDVSDDASLTA 1230
            ||.:..||.:....:..:|...|.|:...|           ...|.::|:......|.:..:.|.
Human   938 SVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQ 1002

  Fly  1231 GEDTIEDESDEE-----KVCQKCFYDGGEIKCVQCRLFFHLECVHLKRPPRTDFVCKTCKPMPQR 1290
            .|||..|..:.:     ::.::......::|                  ..||...:..:||
Human  1003 AEDTEPDPGESKGEPRSEMMEEDLQGASQVK------------------EETDIAEQKSEPM--- 1046

  Fly  1291 PRRRHSNMNGDHDRDEEEPKAKRPRNSLRLSIDKTARPSNGNNNNNNNNSSVNNNNHRRSGRRTN 1355
                        :.||::|:.|           ...:....:::|...:.|.:.:..|:...:..
Human  1047 ------------EVDEKKPEVK-----------VEVKEEEESSSNGTASQSTSPSQPRKKIFKPE 1088

  Fly  1356 EHMPLNSAALYDLLEQIMKHKAAWPFLRPV--LTSEVPDYHQIIKTPMDLAKIKSKLNMGAYQLN 1418
            |   |..|.:..|.....:...:.||.:||  ....:|||..|:|.||||:.||.||:.|.||..
Human  1089 E---LRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEP 1150

  Fly  1419 EELLSDIQLVFRNCDLYNVEGNEIY 1443
            .:.:.|:.|:|.|..|||.:.:.:|
Human  1151 WQYVDDVWLMFNNAWLYNRKTSRVY 1175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503
		DDT	346..411	CDD:214726
		WHIM1	505..554	CDD:292246
		WHIM2	637..666	CDD:292247
		WHIM3	775..813	CDD:292248
		PHD_RSF1	1064..1109	CDD:277018
		PHD	1244..1284	CDD:214584	3/39 (8%)
		Bromo_Acf1_like	1349..1463	CDD:99936	32/97 (33%)
CREBBP	NP_004371.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..179
		Interaction with SRCAP. /evidence=ECO:0000269\|PubMed:10347196	227..410
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..290
		zf-TAZ	363..430	CDD:280324
		KIX	587..667	CDD:280354
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	794..1083		28/188 (15%)
		Bromo_cbp_like	1087..1194	CDD:99927	32/92 (35%)
		Interaction with histone. /evidence=ECO:0000269\|PubMed:24361270	1124..1170		22/45 (49%)
		Interaction with ASF1A. /evidence=ECO:0000269\|PubMed:24616510	1162..1180		5/14 (36%)
		RING_CBP-p300	1206..1278	CDD:276805
		PHD_CBP_p300	1280..1311	CDD:277032
		HAT_KAT11	1342..1649	CDD:285432
		Interaction with histone. /evidence=ECO:0000250\|UniProtKB:Q09472	1433..1435
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q09472	1434..1436
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q09472	1446..1447
		Interaction with TRERF1. /evidence=ECO:0000269\|PubMed:11349124	1460..1891
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1556..1615
		ZZ_CBP	1705..1745	CDD:239077
		ZnF_TAZ	1766..1844	CDD:214717
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1874..1959
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1977..2028
		Med15	1986..>2413	CDD:255446
		Creb_binding	2034..2111	CDD:286163
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2112..2263
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2294..2433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900