DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Acf and Crebbp

DIOPT Version :9

Sequence 1:	NP_536734.2	Gene:	Acf / 43751	FlyBaseID:	FBgn0027620	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	XP_006521814.1	Gene:	Crebbp / 12914	MGIID:	1098280	Length:	2451	Species:	Mus musculus

Alignment Length:	283	Identity:	68/283 - (24%)
Similarity:	107/283 - (37%)	Gaps:	84/283 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1169 DEDVEDDESVTSTPSSSRVNGRILRRPRTRPTSRRLTSK-EIEEHAQEDVDSGDVSDDASLTAGE 1232
            |..|....||||..:||:..|         |....|..| |::            :|||
Mouse   970 DNRVPTPSSVTSAETSSQQPG---------PDVPMLEMKTEVQ------------TDDA------ 1007

  Fly  1233 DTIEDESDEEKVCQKCFYDGGEIKCVQCRLFFHLECVHLKRPPRTDFVCKTCKPMPQRPRRRHSN 1297
               |.|..|.|         ||                    ||::        |.:...:..|.
Mouse  1008 ---EPEPTESK---------GE--------------------PRSE--------MMEEDLQGSSQ 1032

  Fly  1298 MNGDHDRDEE-----EPKAKRPRNSLRLSIDKTARPSNGNNNNNNNNSSVNNNNHRRSGRRTNEH 1357
            :..:.|..|:     |.:.|:|      .:...|:....|::|:..:.|.:.:..|:...:..|
Mouse  1033 VKEETDTTEQKSEPMEVEEKKP------EVKVEAKEEEENSSNDTASQSTSPSQPRKKIFKPEE- 1090

  Fly  1358 MPLNSAALYDLLEQIMKHKAAWPFLRPV--LTSEVPDYHQIIKTPMDLAKIKSKLNMGAYQLNEE 1420
              |..|.:..|.....:...:.||.:||  ....:|||..|:|.||||:.||.||:.|.||...:
Mouse  1091 --LRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQ 1153

  Fly  1421 LLSDIQLVFRNCDLYNVEGNEIY 1443
            .:.|:.|:|.|..|||.:.:.:|
Mouse  1154 YVDDVWLMFNNAWLYNRKTSRVY 1176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503
		DDT	346..411	CDD:214726
		WHIM1	505..554	CDD:292246
		WHIM2	637..666	CDD:292247
		WHIM3	775..813	CDD:292248
		PHD_RSF1	1064..1109	CDD:277018
		PHD	1244..1284	CDD:214584	4/39 (10%)
		Bromo_Acf1_like	1349..1463	CDD:99936	32/97 (33%)
Crebbp	XP_006521814.1	zf-TAZ	362..429	CDD:366931
		KIX	586..666	CDD:366953
		PHA03247	<687..1037	CDD:223021	26/133 (20%)
		COG5076	942..>1194	CDD:227408	68/283 (24%)
		Bromo_cbp_like	1088..1195	CDD:99927	32/92 (35%)
		RING_CBP-p300	1207..1289	CDD:276805
		PHD_CBP_p300	1291..1322	CDD:277032
		HAT_KAT11	1353..>1564	CDD:369758
		ZZ_CBP	1716..1756	CDD:239077
		ZnF_TAZ	1777..1855	CDD:214717
		Med15	1971..>2422	CDD:312941
		Creb_binding	2045..2125	CDD:370251
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900