Protein Alignment Acf and Acf

DIOPT Version :10

• Sequence 1: NP_536734.2
• Gene: Acf / 43751
• FlyBaseID: FBgn0027620
• Length: 1476
• Species: Drosophila melanogaster
• Sequence 2: XP_061496555.1
• Gene: Acf / 1272417
• VectorBaseID: AGAMI1_010748
• Length: 1731
• Species: Anopheles gambiae
• Alignment Length: 1799
• Identity: 558/1799 - (31%)
• Similarity: 813/1799 - (45%)
• Gaps: 426/1799 - (23%)

  Fly     1 MPICKREGFDLNQKEGKNETFHDNDQVFCCYITKRIFRDYEHYFRHVMVINSTVWQCEATGKENL 65
            ||:.:|:   :.||....|...|.|:|..|..|..||.:||.||..:|:|:|.||.|..||:.||
Mosquito     1 MPLLRRQ---VLQKTSTGERLRDGDEVLYCQPTGEIFSNYEDYFHRIMLISSMVWTCAMTGRPNL 62

  Fly    66 TYEEAVKSERAARKKMEQFKQSLRAPVLLVVEHAQQSAVNTLNMIVAKFLRKRYFIGEEVSV--- 127
            ||.||:.||:.|||.::.|..:::.|.|||..|.|::::|.::..|..|::...|.||.|..
Mosquito    63 TYLEALDSEKDARKLLKTFPAAVKGPFLLVASHTQRTSINEMHEDVYGFVKDHLFKGESVDAMDP 127

  Fly   128 --QAKKNATYTVLGVKLDKNMPEPLNGIYEDTDN-LVYRLRPNKG-DPSAELDLPFRQLRRSRME 188
              :|.:.||.|  .|.:|..:          |.| |.|::|.... .|.....|| ..::|.|..
Mosquito   128 VRKAFRRATIT--NVLVDSTL----------TPNALTYQVRAEDDMTPKVWTVLP-GNVKRDRSA 179

  Fly   189 FNLENLSMFIKSNV-SRVDGLLRPKPEAYKQYVTDPGVNFSTIFIGKMPRYSPAK---------- 242
            ...|...:|:|.:| :...|.||.|.::..::||..|.....:|.|:.|.:..:|
Mosquito   180 LTREKCKLFLKQHVEAGPGGQLRIKADSLARFVTGEGWTDGLVFHGQTPSFQQSKRLKQNAERGE 244

  Fly   243 ------------IKKPDGKKQSTLNKYIVAGEATAAKSKAKAKSDA------------------- 276
                        .|:|..:|:.|........:.|....|||.:..|
Mosquito   245 AGGGGAAASTVSTKQPAKQKKQTKQLAADGADGTGKPKKAKTQPPADKGKERKGKELPKAAAGST 309

  Fly   277 --------KSLAEELERVKREKEAKLIELEKQKAEKKAQLIERVENEC----------NLLLQKT 323
                    :|:|:.:|::..|.:|...:.:||: |:.|||..|||.|.          .||.|:.
Mosquito   310 AGGGGGKQQSIAKYVEKLPGETQALEAKAKKQE-EEAAQLRLRVEQEALAKRRAEEEKALLAQQV 373

  Fly   324 -----------DDLERTDQKVLPRYRQIVTLLPEHLLGDAFMMREFMHTYTGLLSGIEVFRQNLS 377
                       :|.|..||:.||..|.:..|:..........:.|:::::..||:....|...|:
Mosquito   374 VLALKRYNAVLEDQELPDQRPLPPVRPVRPLIAARHFSSFVFILEYLNSFADLLAIRSKFPGGLT 438

  Fly   378 FYEMTRALTAREIAGPLSDILLVLLGTVFDLQKEEEEECAVTY--LDRAAQTQEPYWSMAQAAKS 440
            .:.:.|||..||:.||||||..|||..:|..|.|||.|.:|.|  ::..||.::......:|..:
Mosquito   439 IHLLERALILREVNGPLSDIFQVLLSAIFTQQLEEENEESVRYERIEGLAQKRQTVPEQVRARDA 503

  Fly   441 HLYAKRHFSFKVNELPLDALTLSEVLRLHLLGSGAFVNEKAERWRVMYRNGYSSKEDPGLELRLE 505
            .|:.::|:|.|::|:|:|::|:||:||||.|.|||.|.|:|.|.|...|.||.|.:||||.|..:
Mosquito   504 ALWCEKHYSTKLSEMPIDSMTVSELLRLHFLASGALVEERAARHRYQNRGGYGSGDDPGLRLVRD 568

  Fly   506 HSHILRILKNHSVYQLKFKDIMLLIRCLMSQIMTYSGTINLIEERMEQTAKARQDLRA------- 563
            :.||||.|..:|||||...||:.::.||:.|::||||..:|:|||:|:...||...:|
Mosquito   569 YPHILRALNWYSVYQLPVGDIIQILCCLIHQLLTYSGVRDLVEERVEKARTARTSYQANRWAQRR 633

  Fly   564 --LVVGENKRLAAVEINRKKLTQMHHLEVNGVE------PEKREALVEKLKKSIAELHAQSDQQH 620
              :..|..|..|..::.|         |:.|.|      .|.|..|.::|.:..|.:.|.:.:|.
Mosquito   634 LTVKAGSLKNAARDDMKR---------ELAGFEGELAAREEYRRKLTDRLDEQCARIEADAQRQL 689

  Fly   621 RKHELQMLKLHSQLFNFLVYLGMDRCYRKYYVLESMPGIFVEHSPDSLDTCLEQPITNKSQIEIR 685
            :..:.:..:|....|::.:|||.|||||.|::.||:||:||||.......||::|..:...:
Mosquito   690 KVLQAESERLKEDFFDYQIYLGTDRCYRNYWLFESLPGLFVEHDRTYAGRCLDRPTPHIPGL--- 751

  Fly   686 QQSALPKNRK-------------DLRVYLL--KLYGD------------------DEKKTKKKAK 717
             .:..|..||             |..|.||  |...|                  ::..|...||
Mosquito   752 -AACAPDQRKKYITRAIMRCAGTDGVVALLDAKAIADANAVSSSSTRPAPVEEVYEQLLTLGSAK 815

  Fly   718 HSLENKENQEH----RLNGSAEPMD--------VESDSPEAP-THFELLMCSGDKRSCIVHDSRN 769
              ||:.|.|:.    |.| ||||..        ....:|..| ::.|||||:.....|.||..::
Mosquito   816 --LESAEQQQQQGKSRAN-SAEPATDGVNGGAATNLPAPVRPASNQELLMCTAQPDDCPVHTEQH 877

  Fly   770 GQRQRWAYIYKAEEIDELIKALNPNGLREYELLQELSVLRSLIEQHAKTCPVDLLSLENETMRKK 834
            .....|.|...|:|:|.||::||..|.||.:|.:.|...|.||..|...||:|.||: .|..|..
Mosquito   878 PGTVGWGYYATADELDALIRSLNARGAREKQLRETLECERDLIVTHIAKCPLDKLSV-GEADRAG 941

  Fly   835 FMAAMESETNRKYGEANFGLPNGTDLNEVMRLHLVDRIIQFENDIYTGDLGRLKVKDMEKWRSDL 899
            .:|.:.|...::|...||....||:.||::....::.:::.|..|..|.||.::|:|.:|||..|
Mosquito   942 ALADIASRNQKRYDAPNFSHEPGTEPNEILEAVFLENLLELEAKITVGYLGVMRVRDRDKWREAL 1006

  Fly   900 LGGNYDAQC--KLQWGPGGKLEDEAGSDNESHETHEEDDGALLGKYARKPYRDP-GMYLAASADT 961
            ....||||.  .|.||| .:|..:|   .|.....|:.||.  .|..::...:| |..:.:..|.
Mosquito  1007 EAHGYDAQTDKPLVWGP-KRLAPKA---EEGDNGREQQDGE--QKQVKQENGEPNGDRVDSEQDQ 1065

  Fly   962 KP----LP---DSDDEEDQ---------------------------HTNAVSIPI--------AV 984
            ||    ||   |.|.|.|.                           ....||.|:        .|
Mosquito  1066 KPVVAKLPGGGDLDSERDSLERLMSEASHPGQGLPDTTVSLLDETLEGEEVSYPLHESETLRQRV 1130

  Fly   985 HNMASALLQVEQAIGKRFLKEPYGMKKWDPK---------QEALKLACDSRLHQWEVSLMESTSF 1040
            .::..|||||.|.|..:||:.|:|.|| |.|         .|.||     .|.:||||||:||.:
Mosquito  1131 QSLGRALLQVAQCIDPKFLRHPFGPKK-DHKDRAVMQQKQHEGLK-----NLVRWEVSLMQSTCY 1189

  Fly  1041 AQVFLHLNILHDCIQWRRSTNKSLCKVCRRGSDPEKMLLCDECNAGTHMFCLKPKLRSVPPGNWY 1105
            ||:|||.|:|:|.|.|.||..:..|.:|||..||...|||||||...|.:||||||:.||.|:||
Mosquito  1190 AQLFLHYNVLYDAIHWSRSAERICCMICRRKGDPGLTLLCDECNRACHTYCLKPKLKEVPAGDWY 1254

  Fly  1106 CNDCVKSLGLSNGQNEKDKKQATKKKRKFIVEEEDDEATDEEEEEKKDD-------------DMT 1157
            |..|       ..:|.|:|..|.:||:|.:...:|||..||||||::.:             |..
Mosquito  1255 CKRC-------RPENFKEKPSANRKKKKKMFRWKDDEEEDEEEEEEEQEEDEEEQNGRGHRRDEM 1312

  Fly  1158 DEDAEHENEKHDEDVED----------DESVTSTPSS---------------------------- 1184
            :||||.|..:...:.||          |||..|..|.
Mosquito  1313 EEDAEEEEVEEQAEEEDGDGVEQRNEADESAGSQGSGPEDGAEENDDDGSDADYRAKRSKLMVKV 1377

  Fly  1185 SRVNGRILRRPRTRP----TSRRLTSK---------------EIEEHAQEDVDSGDVSDDASLTA 1230
            ::|..|...:.:.:|    ||...||:               |.:|...:|.|:|:..:|.
Mosquito  1378 AKVAKRSKPKAKAKPTIVVTSTGRTSRSTAATNGAYRYGDDGEDDEEKDDDDDNGEEEEDE---- 1438

  Fly  1231 GEDTIEDESDEEKVCQKCFYDGGEIKCVQCRLFFHLECVHLKRPPRTDFVCKTCKPMPQRPRRRH 1295
             ::||.||.||.       ||                    :|..|.           :|||...
Mosquito  1439 -DETIADEDDES-------YD--------------------EREERR-----------KRPRAAA 1464

  Fly  1296 SNMNGDHDR---------------------DEEEPKAKRPRNSLR--------LSIDKTARPSNG 1331
            |..||..||                     |...|.:||.|.:..        .:||....|..|
Mosquito  1465 SLSNGGADRKRNNAQRRSASKKHKRAGDAQDVSPPASKRARRATNGRAKVAGPGTIDSDEEPLGG 1529

  Fly  1332 NNNNN--NNNSSVNNNNHRRS----------------------------------GRRTNEHMPL 1360
            ..:..  ...|:.:....|||                                  .|||.:.:||
Mosquito  1530 GGSRKAPTRTSARSTKGQRRSSPYNDYDDEELDDEEDGDEEGTVARLRIGAAARRSRRTGDDLPL 1594

  Fly  1361 NSAALYDLLEQIMKHKAAWPFLRPVLTSEVPDYHQIIKTPMDLAKIKSKLNMGAYQLNEELLSDI 1425
            ||.|||.|::.|:||..:|||.|||...|||||:.:||:|||.|:||||||||.|::||::|||:
Mosquito  1595 NSVALYTLIDDILKHPNSWPFNRPVSAKEVPDYYAVIKSPMDFARIKSKLNMGDYKINEQMLSDV 1659

  Fly  1426 QLVFRNCDLYNVEGNEIYDAGCQLERFVIDRCRDMQLPFRPSDM 1469
            |||||||||||.:..::|..|..|||:|:.||:::.|||:||||
Mosquito  1660 QLVFRNCDLYNTDETDVYRIGRDLERYVVKRCKELNLPFQPSDM 1703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:463140	41/98 (42%)
		DDT	346..411	CDD:214726	21/64 (33%)
		WSD	641..>666	CDD:464775	16/24 (67%)
		WSD	<774..805	CDD:464775	13/30 (43%)
		PHD_RSF1	1064..1109	CDD:277018	26/44 (59%)
		PHD	1244..1284	CDD:214584	4/39 (10%)
		Bromo_Acf1_like	1349..1463	CDD:99936	66/147 (45%)
Acf	XP_061496555.1	None