DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acf and BAZ2A

DIOPT Version :9

Sequence 1:	NP_536734.2	Gene:	Acf / 43751	FlyBaseID:	FBgn0027620	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	XP_011536103.1	Gene:	BAZ2A / 11176	HGNCID:	962	Length:	1912	Species:	Homo sapiens

Alignment Length:	1724	Identity:	340/1724 - (19%)
Similarity:	552/1724 - (32%)	Gaps:	688/1724 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EHYFRHVMVI--NSTVWQCEA-----TGKENLTYEEAVK--SERAARK-KMEQFKQSLRAPV--- 92
            :|.:|..:.|  .|..||.|.     .||....:.|.:|  |...... :.|.|..|.|.||
Human   557 QHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRNVVHSVRREHFSFSPRMPVGDF 621

  Fly    93 ---------LLVVEHAQQSAVNTLNMIVAKFLRKRYFIGEEVSVQAKKNATYTVLGVKLDKNMPE 148
                     |..|:.:.:...:.:..|..|..|.|         ..:|..|..|..||..:..|.
Human   622 FEERDTPEGLQWVQLSAEEIPSRIQAITGKRGRPR---------NTEKAKTKEVPKVKRGRGRPP 677

  Fly   149 --PLNGIYEDTDNLVYRLRPNKGDPSAELDLPFRQLRRSRMEFNLENLSMFIKSNVSRVDGLLRP 211
              .:..:...|||     ||.|                 ::|.. |.|:...|:.:::....:|.
Human   678 KVKITELLNKTDN-----RPLK-----------------KLEAQ-ETLNEEDKAKIAKSKKKMRQ 719

  Fly   212 KPEAYKQYVTDPGVNFSTIFIGKMPRYSPAKIKKPDGKKQSTLNKYIVAGEATAAKSKAKA-KSD 275
            |.:..:...|..|               .|:.|    :||.|  |.:...|   ||.|:|| |..
Human   720 KVQRGECQTTIQG---------------QARNK----RKQET--KSLKQKE---AKKKSKAEKEK 760

  Fly   276 AKSLAEEL-ERVKREKEAKLIELEKQ---------KAEK----KAQLIERVENECNL--LLQKTD 324
            .|:..|:| |:|||||:.|:...||:         ||:|    :.:|.||...:..|  :.:.|:
Human   761 GKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKKPTE 825

  Fly   325 DLERTDQKVLPRYRQIVTL-LPEHLLGDAFMMREFMHTYTGLLSGIEVFRQNLSFYEMTRALTAR 388
            |:..||.:.||.:.::..| ||.....|...:.||:|:: |.:.|.:..:...|...:...|..:
Human   826 DMCLTDHQPLPDFSRVPGLTLPSGAFSDCLTIVEFLHSF-GKVLGFDPAKDVPSLGVLQEGLLCQ 889

  Fly   389 -EIAGPLSDILLVLLGTVFDLQKEEEEECAVTYLDRAAQTQEPYWSMAQAAKSHLYAKRHFSFKV 452
             :..|.:.|:|:.||                    :||.....:.|..|:.|.       ...||
Human   890 GDSLGEVQDLLVRLL--------------------KAALHDPGFPSYCQSLKI-------LGEKV 927

  Fly   453 NELPLDALTLSEVLRLHLLGSGAFVNEKAERWRVMYRNGYSSKEDPGLELRL-----------EH 506
            :|:||....:||:||..|:..|.                     :|.|..||           :.
Human   928 SEIPLTRDNVSEILRCFLMAYGV---------------------EPALCDRLRTQPFQAQPPQQK 971

  Fly   507 SHILRILKNHSVYQLKFKDIMLLIRCLMSQIMTYSGTINLIEERMEQTAKARQDLRALVVGENKR 571
            :.:|..|    |::|....::                ||.|::.:|..:..|:: :.:|.|..:|
Human   972 AAVLAFL----VHELNGSTLI----------------INEIDKTLESMSSYRKN-KWIVEGRLRR 1015

  Fly   572 LAAVE-----------------INRKKLTQMHHLEVNGVEPE--------------KREALVEKL 605
            |..|.                 :.|::.:::.. |.:|:|.|              :|:..|:..
Human  1016 LKTVLAKRTGRSEVEMEGPEECLGRRRSSRIME-ETSGMEEEEEEESIAAVPGRRGRRDGEVDAT 1079

  Fly   606 KKSIAELHAQSDQQHRKHELQMLK--LHSQLFNFLVYLGMDRCYRKYYVLESMPGIFVE------ 662
            ..||.||..|.::. .|.:|...|  |||......|.||.||..|:|:||..:.|||||
Human  1080 ASSIPELERQIEKL-SKRQLFFRKKLLHSSQMLRAVSLGQDRYRRRYWVLPYLAGIFVEGTEGNL 1143

  Fly   663 -------HSPDSLDTC---------------------------------------------LEQP 675
                   ...|||...                                             |:.|
Human  1144 VPEEVIKKETDSLKVAAHASLNPALFSMKMELAGSNTTASSPARARGRPRKTKPGSMQPRHLKSP 1208

  Fly   676 I----TNKSQIEIRQQSAL-----PKNRKDLRVYLLKLYGDDEKK--TKKKAKHSLEN------- 722
            :    :.:.|.:::.::.|     |:.:..|::...|.:.:.|..  :..:::|.|..
Human  1209 VRGQDSEQPQAQLQPEAQLHAPAQPQPQLQLQLQSHKGFLEQEGSPLSLGQSQHDLSQSAFLSWL 1273

  Fly   723 KENQEHR--LNGSA---------------------EPMDVESD---------------------- 742
            .:.|.|.  |:.|.                     ||.:.||.
Human  1274 SQTQSHSSLLSSSVLTPDSSPGKLDPAPSQPPEEPEPDEAESSPDPQALWFNISAQMPCNAAPTP 1338

  Fly   743 ----------------------------SPEAPTHFELLMCSG--DKRSC------------IVH 765
                                        :|.:|..|.....:|  .||..            :..
Human  1339 PPAVSEDQPTPSPQQLASSKPMNRPSAANPCSPVQFSSTPLAGLAPKRRAGDPGEMPQSPTGLGQ 1403

  Fly   766 DSRNGQ---------RQR-----------------WAYIYKAEEIDELIKALNPNGLREYELLQE 804
            ..|.|:         .||                 |.:|...|.:|.::|||:|.|:||..|.:.
Human  1404 PKRRGRPPSKFFKQMEQRYLTQLTAQPVPPEMCSGWWWIRDPEMLDAMLKALHPRGIREKALHKH 1468

  Fly   805 LSVLRSLIEQHAKTCPVDLLSLENETMRKKFMAAME------SETNRKYGEANFGLPNGTDLNEV 863
            |:..|..:::      |.|....:.....:.:.|.:      |...:.|         .||
Human  1469 LNKHRDFLQE------VCLRPSADPIFEPRQLPAFQEGIMSWSPKEKTY---------ETD---- 1514

  Fly   864 MRLHLVDRIIQFENDIYTGDLGRLKVKDMEKWRSDLLGGNYDAQCKLQWGPGGKLEDEAGSDNES 928
              |.::..:.:.|..:...||      .:..|           .|.   .|....||.|..::.|
Human  1515 --LAVLQWVEELEQRVIMSDL------QIRGW-----------TCP---SPDSTREDLAYCEHLS 1557

  Fly   929 HETHEEDDGALLGKYARKPYRDPGMYLAASADTKPLPDSDDEEDQHTNAVSIPIAVHNMASALLQ 993
             ::.|:......|:....|.|         ..|.||                .:||..:|:
Human  1558 -DSQEDITWRGRGREGLAPQR---------KTTNPL----------------DLAVMRLAA---- 1592

  Fly   994 VEQAIGKRFLKEPYGMKKWDPKQEALKLACDS--------------------------RLHQWEV 1032
            :||.:.:|:|:||.    |...:..|:.|..|                          |:..|..
Human  1593 LEQNVERRYLREPL----WPTHEVVLEKALLSTPNGAPEGTTTEISPLSPSRSYEITPRIRVWRQ 1653

  Fly  1033 SLMESTSFAQVFLHLNILHDCIQWRRSTNKSLCKVCRRGSDPEKMLLCDECNAGTHMFCLKPKLR 1097
            :|....|.|||.|.|..|...|.|.:|.||..|.|||:|.:.|.:||||.|:.|.|::|.:||:.
Human  1654 TLERCRSAAQVCLCLGQLERSIAWEKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKME 1718

  Fly  1098 SVPPGNWYCNDCVKSLGLSNGQNEKDKKQATKKKRKFIVEEEDDEATDEEEEEKKDDDMTDEDAE 1162
            :||.|:|:|..|:
Human  1719 AVPEGDWFCTVCL---------------------------------------------------- 1731

  Fly  1163 HENEKHDEDVEDDESVTSTPSSSRVNGRILRRPRTRPTSRRLTSKEIEEHAQEDVDSGDVSDDAS 1227
                                 :.:|.|...::|
Human  1732 ---------------------AQQVEGEFTQKP-------------------------------- 1743

  Fly  1228 LTAGEDTIEDESDEEKVCQKCFYDGGEIKCVQCRLFFHLECVHLKRPPRTDFVCKTCKPMPQRPR 1292
                                                                      ..|:|.:
Human  1744 ----------------------------------------------------------GFPKRGQ 1750

  Fly  1293 RRHSNMNGDHDRDEEEPKAKRPRNSLRLSIDKTARPSNGNNNNNNNNSSVNNNNHRRSGRRTNEH 1357
            :|.|.    :..:..|...:|.|..||......|.|       ..:...::.:..||...| |.|
Human  1751 KRKSG----YSLNFSEGDGRRRRVLLRGRESPAAGP-------RYSEEGLSPSKRRRLSMR-NHH 1803

  Fly  1358 MPLNSAALYDLLEQIMKHKAAWPFLRPVLTSEVPDYHQIIKTPMDLAKIKSKLNMGAYQLNEELL 1422
            ..|....:  :|.::..|.||||||.||....|..|.:|||.|||.:.::.:|..|.|..:||..
Human  1804 SDLTFCEI--ILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFA 1866

  Fly  1423 SDIQLVFRNCDLYNVEGNEIYDAGCQLERFVIDR 1456
            :|..|||.||..:|.:.:|:..||..:.||...|
Human  1867 ADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESR 1900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503	24/105 (23%)
		DDT	346..411	CDD:214726	13/65 (20%)
		WHIM1	505..554	CDD:292246	8/48 (17%)
		WHIM2	637..666	CDD:292247	14/41 (34%)
		WHIM3	775..813	CDD:292248	14/37 (38%)
		PHD_RSF1	1064..1109	CDD:277018	21/44 (48%)
		PHD	1244..1284	CDD:214584	0/39 (0%)
		Bromo_Acf1_like	1349..1463	CDD:99936	41/108 (38%)
BAZ2A	XP_011536103.1	HAT_MBD	551..623	CDD:238691	18/65 (28%)
		DDT	848..913	CDD:214726	15/85 (18%)
		WHIM3	1439..1477	CDD:292248	14/37 (38%)
		PHD_BAZ2A	1685..1731	CDD:277099	21/45 (47%)
		Bromo_BAZ2A_B_like	1805..1901	CDD:99935	37/98 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900