DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acf and brd8a

DIOPT Version :9

Sequence 1:	NP_536734.2	Gene:	Acf / 43751	FlyBaseID:	FBgn0027620	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	XP_017208471.1	Gene:	brd8a / 100003763	ZFINID:	ZDB-GENE-091113-54	Length:	820	Species:	Danio rerio

Alignment Length:	945	Identity:	180/945 - (19%)
Similarity:	294/945 - (31%)	Gaps:	348/945 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   602 VEKLKKSIAELHAQSDQQHRKHELQMLKLHSQLFNFLVYLGMDRCYRKYYVLESMPGIFVEHSPD 666
            :|:||:.|.:    :.::|||     ||..|:|                        |...|...
Zfish   104 IEELKRLIKD----TQEKHRK-----LKRESEL------------------------IQAGHLDS 135

  Fly   667 SLDTCLEQPITNKSQIEIRQQSALPKNRKDLRVYLLKLYGDDEKKTKKK-------AKHSLENKE 724
            .|:...|:.:.::.|.|                        :|.:.|:|       |:.:::|..
Zfish   136 KLEELWEEIVRSRKQEE------------------------EEAEVKRKATDAAYQARQAVKNTP 176

  Fly   725 NQEHRL-----NGSAEP-MDVE-SDSPEAPTHFELLMCSGDKRSCIVHDSRNGQRQRWAYIYKAE 782
            .:...:     :|:..| :|.. .||.|.|                      |.......::..
Zfish   177 KRVPSVTVRSPSGACSPSLDFPIGDSSEDP----------------------GSTAAGPTVFVP- 218

  Fly   783 EIDELIKALNPNGLREYEL--LQELSVLRSLIEQHAKTCPVDLLSLENETMRKKFM------AAM 839
                 :..|...|:.|..|  |.:.|..:.|:.|.....|..|||   |.::|..:      .|:
Zfish   219 -----LTELPGPGVVEASLGSLLDESTQKKLLGQKITPPPSPLLS---ELLKKGSLLPTSPRLAV 275

  Fly   840 ESETNRKYGEANFGLPN----GTDLNEVMRLHL-----------VDRIIQFENDIYTGDLGRLKV 889
            |.||           |:    |:..|::|...|           :.|:::.....:...|..|..
Zfish   276 EGET-----------PSNQLAGSHENQMMTSSLPASQAATGAPTLSRLLEAGPAQFPSQLSSLAT 329

  Fly   890 KDMEKWRSDLLGGNYDAQCKLQWGPGGKLEDEAGS--DNESHETHEEDDGALLGKYARKPYRDPG 952
            .|.   .........|....|..|.|.     ||:  ||:.....|||...:
Zfish   330 ADS---APSAATSAVDVVAPLSTGEGA-----AGASVDNKEAVLGEEDLVTV------------- 373

  Fly   953 MYLAASADTKPLPD--SDDEEDQHTNAVSIPIAVHNMASALLQVEQAIGKRFLKEPYGMK---KW 1012
            .|:|...|.:.:.|  :..||....||.::..||         ||.|:.   |.|..|..   .|
Zfish   374 SYMAEELDLETVGDIIAIIEEKGDENAEALDAAV---------VEAALS---LCEDTGHSLTGSW 426

  Fly  1013 DPKQEALKLACDSRLHQWEVSLMESTSFAQVFLH-LNILHDCIQWRRSTNKSLCKVCRRGSDPEK 1076
            :|  ...:..|..          .|::.|.:..| ||:|..               .|.|.|
Zfish   427 EP--NPFRPICPE----------PSSTSADLDPHSLNLLEG---------------KREGPD--- 461

  Fly  1077 MLLCDECNAGTHMFCL-KPKLRSVPPGNWYCNDCVKSLGLSNGQNEKDKKQATKKKRKFIVEEED 1140
              .|...:....|:.. ...:.|||      .|....:||:   :|.|..:          .|..
Zfish   462 --ACGSSSGCAQMYSTPSSTVPSVP------QDPTPIVGLN---SEPDTPR----------PEHT 505

  Fly  1141 DEATDEEEEEKKDDDMTDEDAEHENEKHDEDVEDDESVTSTPSSSRVNGRILRRPRTRPTSRRLT 1205
            |:|.||:.|..  ..:...:||.......:....|:.|....|..
Zfish   506 DQAQDEQPESL--HSLIKSEAEEWTRSQSDTRSVDDPVIKQHSKE-------------------- 548

  Fly  1206 SKEIEEHAQEDVDSGDVSDDASLTAGEDTIEDESDEEKVCQKCFYDGGEIKCVQCRLFFHLECVH 1270
            .||.||.|..|.:.|.||:..|...| |..||...||        ||              :.|:
Zfish   549 VKEEEEEAASDAEEGSVSEMKSGLEG-DGAEDCGGEE--------DG--------------DAVY 590

  Fly  1271 LKRPPRTDFVCKTCKPMPQRPRRRHSNMNGDHDRDEEEPKAKRPRNSLRLSIDKTARPSNGNNNN 1335
            |                        |..:||.:                  :|..|..|....:.
Zfish   591 L------------------------SEADGDTE------------------LDPPASESEDGYSM 613

  Fly  1336 NNNNSSVNNNNHRRSGRRTNEHMPLNSA----------------------ALYDLLEQIMKHKAA 1378
            :..:||:..:.       |.:.:|.:.|                      |:..:......|:.|
Zfish   614 HTASSSIQLHT-------TADSIPSSPASSQFSICSEDQEAIQAQKIWKKAIMLVWRAAANHRYA 671

  Fly  1379 WPFLRPVLTSEVPDYHQIIKTPMDLAKIKSKLNMGAYQLNEELLSDIQLVFRNCDLYNVEGNEIY 1443
            ..||:||.....|.||.|:..||||:.||..:..|..:...|...||.|:|:|..:||...::::
Zfish   672 NVFLQPVTDDIAPGYHSIVHRPMDLSTIKKNIENGLIRTTAEFQRDIMLMFQNAVMYNSSDHDVF 736

  Fly  1444 DAGCQLERFVIDRCRDM---QLPFRPSDMNGEVKA 1475
            ....:::|.|:::.:..   ||..:.|:.....|:
Zfish   737 HMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKS 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acf	NP_536734.2	WAC_Acf1_DNA_bd	26..125	CDD:287503
		DDT	346..411	CDD:214726
		WHIM1	505..554	CDD:292246
		WHIM2	637..666	CDD:292247	2/28 (7%)
		WHIM3	775..813	CDD:292248	7/39 (18%)
		PHD_RSF1	1064..1109	CDD:277018	8/45 (18%)
		PHD	1244..1284	CDD:214584	4/39 (10%)
		Bromo_Acf1_like	1349..1463	CDD:99936	32/138 (23%)
brd8a	XP_017208471.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810