Protein Alignment Mccc1 and PYC1

DIOPT Version :10

• Sequence 1: NP_651896.1
• Gene: Mccc1 / 43750
• FlyBaseID: FBgn0039877
• Length: 698
• Species: Drosophila melanogaster
• Sequence 2: NP_011453.1
• Gene: PYC1 / 852818
• SGDID: S000003030
• Length: 1178
• Species: Saccharomyces cerevisiae
• Alignment Length: 686
• Identity: 236/686 - (34%)
• Similarity: 360/686 - (52%)
• Gaps: 72/686 - (10%)

  Fly    28 SKILISNRGEIACRVIRTARKLGVRTVAVFSDPDEKSMHTQLADESYRVGEAAS---SASYLRGE 89
            :|||::|||||..|:.|||.:|.::|||::|..|..|.|.|.|||:|.:||...   ..:||..:
Yeast    20 NKILVANRGEIPIRIFRTAHELSMQTVAIYSHEDRLSTHKQKADEAYVIGEVGQYTPVGAYLAID 84

  Fly    90 RILDIAKRSGAQAIHPGYGFLSESVEFAELCQREGIIFMGPPSSAIRDMGIKSTSKAIMAAAGVP 154
            .|:.||::.....||||||||||:.|||:...:.||.::|||:..|..:|.|.:::.:.|.|.||
Yeast    85 EIISIAQKHQVDFIHPGYGFLSENSEFADKVVKAGITWIGPPAEVIDSVGDKVSARNLAAKANVP 149

  Fly   155 IINGYHGDDQSDECLQREADKIGFPLMIKAVRGGGGKGMRIAEKPDDFLTALNSARTESEKSFGD 219
            .:.|..|..::.|......::.|:|::|||..||||:|||:..:.||...|...|.:|:..:||:
Yeast   150 TVPGTPGPIETVEEALDFVNEYGYPVIIKAAFGGGGRGMRVVREGDDVADAFQRATSEARTAFGN 214

  Fly   220 SSVLLERYVRSPRHVEVQVFADQYGDAVYLWERDCSVQRRHQKIIEEAPAPGLSEDLRRELGEAA 284
            .:..:||::..|:|:|||:.||.:|:.|:|:||||||||||||::|.|||..|..::|..:...|
Yeast   215 GTCFVERFLDKPKHIEVQLLADNHGNVVHLFERDCSVQRRHQKVVEVAPAKTLPREVRDAILTDA 279

  Fly   285 VRAAKAVGYVGAGTVEFILDKEDLSFHFMEMNTRLQVEHPITEMITGTDLVEWQIRIAAGEPLP- 348
            |:.||..||..|||.||::|.:: ..:|:|:|.|:||||.|||.|||.|:|..||:||||..||
Yeast   280 VKLAKECGYRNAGTAEFLVDNQN-RHYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGASLPQ 343

  Fly   349 --LKQSEITRRGHAFEARIYAENPRGGFLPGAGPLR-YLSTPQPSNNVRVETG-VREGDEVSVHY 409
              |.|.:||.||.|.:.||..|:|...|.|..|.:. |.|.  ..|.||::.| ...|..:|.||
Yeast   344 LGLFQDKITTRGFAIQCRITTEDPAKNFQPDTGRIEVYRSA--GGNGVRLDGGNAYAGTIISPHY 406

  Fly   410 DPMIAKLVVWGENRTQALNSLVARLGEYHISGLDTNINFLIDLASHPEFQLANVHTGFIDEQFDT 474
            |.|:.|....|.........::..|.|:.|.|:.|||.||:.|.::|.|......|.|||   ||
Yeast   407 DSMLVKCSCSGSTYEIVRRKMIRALIEFRIRGVKTNIPFLLTLLTNPVFIEGTYWTTFID---DT 468

  Fly   475 --LFPPIIISPQQVSQAALALVLNELQAAFRNGN--KDQDPFVATPNARLNYSLVRRYDLKANEK 535
              ||.  ::|.|..:|.    :|:.|.....||:  |.|   :..|..:.|.|:...:|.:.|
Yeast   469 PQLFQ--MVSSQNRAQK----LLHYLADVAVNGSSIKGQ---IGLPKLKSNPSVPHLHDAQGN-- 522

  Fly   536 VYSVAVKFDGED-MQIQVDNGDWQDAKVERVQDGSRL-------KIRANINSNVTTYN-ASIDGT 591
            |.:|........ .|:.::.|..:.|:..|..:|:.|       ..::.:.:.|.|:: |:|..|
Yeast   523 VINVTKSAPPSGWRQVLLEKGPAEFARQVRQFNGTLLMDTTWRDAHQSLLATRVRTHDLATIAPT 587

  Fly   592 SVSLFSES------GKVDFEVGQPKFLSAQGDQLGAVGSRIVAPMPGILEKVLVKPGDKVKKGEN 650
            :....:..      |...|:|.. :||...                         |.::::|..:
Yeast   588 TAHALAGRFALECWGGATFDVAM-RFLHED-------------------------PWERLRKLRS 626

  Fly   651 LAVLIAMKMEHILKAPKDATIKSIGGAAGDNVAKGA 686
            |...|..:|  :|:........|:...|.|:..|.|
Yeast   627 LVPNIPFQM--LLRGANGVAYSSLPDNAIDHFVKQA 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mccc1	NP_651896.1	PccA	26..478	CDD:443802	193/459 (42%)
		biotinyl_domain	626..691	CDD:133459	11/61 (18%)
PYC1	NP_011453.1	pyruv_carbox	21..1169	CDD:130302	236/685 (34%)