DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mccc1 and PYC1

DIOPT Version :9

Sequence 1:NP_001247391.1 Gene:Mccc1 / 43750 FlyBaseID:FBgn0039877 Length:698 Species:Drosophila melanogaster
Sequence 2:NP_011453.1 Gene:PYC1 / 852818 SGDID:S000003030 Length:1178 Species:Saccharomyces cerevisiae


Alignment Length:753 Identity:252/753 - (33%)
Similarity:370/753 - (49%) Gaps:122/753 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 SKILISNRGEIACRVIRTARKLGVRTVAVFSDPDEKSMHTQLADESYRVGEAAS---SASYLRGE 89
            :|||::|||||..|:.|||.:|.::|||::|..|..|.|.|.|||:|.:||...   ..:||..:
Yeast    20 NKILVANRGEIPIRIFRTAHELSMQTVAIYSHEDRLSTHKQKADEAYVIGEVGQYTPVGAYLAID 84

  Fly    90 RILDIAKRSGAQAIHPGYGFLSESVEFAELCQREGIIFMGPPSSAIRDMGIKSTSKAIMAAAGVP 154
            .|:.||::.....||||||||||:.|||:...:.||.::|||:..|..:|.|.:::.:.|.|.||
Yeast    85 EIISIAQKHQVDFIHPGYGFLSENSEFADKVVKAGITWIGPPAEVIDSVGDKVSARNLAAKANVP 149

  Fly   155 IINGYHGDDQSDECLQREADKIGFPLMIKAVRGGGGKGMRIAEKPDDFLTALNSARTESEKSFGD 219
            .:.|..|..::.|......::.|:|::|||..||||:|||:..:.||...|...|.:|:..:||:
Yeast   150 TVPGTPGPIETVEEALDFVNEYGYPVIIKAAFGGGGRGMRVVREGDDVADAFQRATSEARTAFGN 214

  Fly   220 SSVLLERYVRSPRHVEVQVFADQYGDAVYLWERDCSVQRRHQKIIEEAPAPGLSEDLRRELGEAA 284
            .:..:||::..|:|:|||:.||.:|:.|:|:||||||||||||::|.|||..|..::|..:...|
Yeast   215 GTCFVERFLDKPKHIEVQLLADNHGNVVHLFERDCSVQRRHQKVVEVAPAKTLPREVRDAILTDA 279

  Fly   285 VRAAKAVGYVGAGTVEFILDKEDLSFHFMEMNTRLQVEHPITEMITGTDLVEWQIRIAAGEPLP- 348
            |:.||..||..|||.||::|.:: ..:|:|:|.|:||||.|||.|||.|:|..||:||||..|| 
Yeast   280 VKLAKECGYRNAGTAEFLVDNQN-RHYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGASLPQ 343

  Fly   349 --LKQSEITRRGHAFEARIYAENPRGGFLPGAGPLR-YLSTPQPSNNVRVETG-VREGDEVSVHY 409
              |.|.:||.||.|.:.||..|:|...|.|..|.:. |.|.  ..|.||::.| ...|..:|.||
Yeast   344 LGLFQDKITTRGFAIQCRITTEDPAKNFQPDTGRIEVYRSA--GGNGVRLDGGNAYAGTIISPHY 406

  Fly   410 DPMIAKLVVWGENRTQALNSLVARLGEYHISGLDTNINFLIDLASHPEFQLANVHTGFIDEQFDT 474
            |.|:.|....|.........::..|.|:.|.|:.|||.||:.|.::|.|......|.|||   ||
Yeast   407 DSMLVKCSCSGSTYEIVRRKMIRALIEFRIRGVKTNIPFLLTLLTNPVFIEGTYWTTFID---DT 468

  Fly   475 --LFPPIIISPQQVSQAALALVLNELQAAFRNGN--KDQDPFVATPNARLNYSLVRRYDLKANEK 535
              ||.  ::|.|..:|.    :|:.|.....||:  |.|   :..|..:.|.|:...:|.:.|  
Yeast   469 PQLFQ--MVSSQNRAQK----LLHYLADVAVNGSSIKGQ---IGLPKLKSNPSVPHLHDAQGN-- 522

  Fly   536 VYSVA-------------VKFDGE-DMQIQVDNG------DWQDAKVE------RVQDGSRL--- 571
            |.:|.             .|...| ..|::..||      .|:||...      |..|.:.:   
Yeast   523 VINVTKSAPPSGWRQVLLEKGPAEFARQVRQFNGTLLMDTTWRDAHQSLLATRVRTHDLATIAPT 587

  Fly   572 -----------------------------------KIRA---NI-------NSNVTTYNASIDGT 591
                                               |:|:   ||       .:|...| :|:...
Yeast   588 TAHALAGRFALECWGGATFDVAMRFLHEDPWERLRKLRSLVPNIPFQMLLRGANGVAY-SSLPDN 651

  Fly   592 SVSLFSESGKVDFEVGQPKFLSAQGD--QLGAVGSRIVAPMPGILEKVLVKPGDKVKKGE----- 649
            ::..|.:..| |..|...:...|..|  || .||...|....|::|..:...||.::.|:     
Yeast   652 AIDHFVKQAK-DNGVDIFRVFDALNDLEQL-KVGVDAVKKAGGVVEATVCFSGDMLQPGKKYNLD 714

  Fly   650 ---NLAVLIAMKMEHILKAPKDATIKSIGGAAGDNVAK 684
               .:|..|.....|||      .||.:.|......||
Yeast   715 YYLEIAEKIVQMGTHIL------GIKDMAGTMKPAAAK 746

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mccc1NP_001247391.1 PccA 27..693 CDD:227111 252/753 (33%)
CPSase_L_chain 27..135 CDD:278706 50/109 (46%)
CPSase_L_D2 141..348 CDD:280881 91/206 (44%)
Biotin_carb_C 362..469 CDD:214878 35/108 (32%)
biotinyl_domain 626..691 CDD:133459 16/67 (24%)
PYC1NP_011453.1 PycA 14..1170 CDD:223968 252/753 (33%)
CPSase_L_chain 20..130 CDD:278706 50/109 (46%)
CPSase_L_D2 135..329 CDD:280881 84/194 (43%)
Biotin_carb_C 359..466 CDD:214878 35/108 (32%)
DRE_TIM_PC_TC_5S 559..840 CDD:163675 38/197 (19%)
PYC_OADA 851..1050 CDD:280576
biotinyl_domain 1102..1168 CDD:133459
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.