DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mccc1 and PYC2

DIOPT Version :9

Sequence 1:	NP_001247391.1	Gene:	Mccc1 / 43750	FlyBaseID:	FBgn0039877	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_009777.1	Gene:	PYC2 / 852519	SGDID:	S000000422	Length:	1180	Species:	Saccharomyces cerevisiae

Alignment Length:	732	Identity:	248/732 - (33%)
Similarity:	379/732 - (51%)	Gaps:	90/732 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SKILISNRGEIACRVIRTARKLGVRTVAVFSDPDEKSMHTQLADESYRVGEAAS---SASYLRGE 89
            :|||::|||||..|:.|:|.:|.:||:|::|..|..|||...|||:|.:||...   ..:||..:
Yeast    21 NKILVANRGEIPIRIFRSAHELSMRTIAIYSHEDRLSMHRLKADEAYVIGEEGQYTPVGAYLAMD 85

  Fly    90 RILDIAKRSGAQAIHPGYGFLSESVEFAELCQREGIIFMGPPSSAIRDMGIKSTSKAIMAAAGVP 154
            .|::|||:.....||||||||||:.|||:...:.||.::|||:..|..:|.|.:::.:.|.|.||
Yeast    86 EIIEIAKKHKVDFIHPGYGFLSENSEFADKVVKAGITWIGPPAEVIDSVGDKVSARHLAARANVP 150

  Fly   155 IINGYHGDDQSDECLQREAD---KIGFPLMIKAVRGGGGKGMRIAEKPDDFLTALNSARTESEKS 216
            .:.|..|   ..|.:|...|   :.|:|::|||..||||:|||:..:.||...|...|.:|:..:
Yeast   151 TVPGTPG---PIETVQEALDFVNEYGYPVIIKAAFGGGGRGMRVVREGDDVADAFQRATSEARTA 212

  Fly   217 FGDSSVLLERYVRSPRHVEVQVFADQYGDAVYLWERDCSVQRRHQKIIEEAPAPGLSEDLRRELG 281
            ||:.:..:||::..|:|:|||:.||.:|:.|:|:||||||||||||::|.|||..|..::|..:.
Yeast   213 FGNGTCFVERFLDKPKHIEVQLLADNHGNVVHLFERDCSVQRRHQKVVEVAPAKTLPREVRDAIL 277

  Fly   282 EAAVRAAKAVGYVGAGTVEFILDKEDLSFHFMEMNTRLQVEHPITEMITGTDLVEWQIRIAAGEP 346
            ..||:.||..||..|||.||::|.:: ..:|:|:|.|:||||.|||.|||.|:|..||:||||..
Yeast   278 TDAVKLAKVCGYRNAGTAEFLVDNQN-RHYFIEINPRIQVEHTITEEITGIDIVSAQIQIAAGAT 341

  Fly   347 LP---LKQSEITRRGHAFEARIYAENPRGGFLPGAGPLR-YLSTPQPSNNVRVETG-VREGDEVS 406
            |.   |.|.:||.||.:.:.||..|:|...|.|..|.|. |.|.  ..|.||::.| ...|..:|
Yeast   342 LTQLGLLQDKITTRGFSIQCRITTEDPSKNFQPDTGRLEVYRSA--GGNGVRLDGGNAYAGATIS 404

  Fly   407 VHYDPMIAKLVVWGENRTQALNSLVARLGEYHISGLDTNINFLIDLASHPEFQLANVHTGFIDEQ 471
            .|||.|:.|....|.........::..|.|:.|.|:.|||.||:.|.::|.|......|.|||
Yeast   405 PHYDSMLVKCSCSGSTYEIVRRKMIRALIEFRIRGVKTNIPFLLTLLTNPVFIEGTYWTTFID-- 467

  Fly   472 FDT--LFPPIIISPQQVSQAALALVLNELQAAFRNGN--KDQDPFVATPNARLNYSLVRRYDLKA 532
             ||  ||.  ::|.|..:|.    :|:.|.....||:  |.|   :..|..:.|.|:...:|.:.
Yeast   468 -DTPQLFQ--MVSSQNRAQK----LLHYLADLAVNGSSIKGQ---IGLPKLKSNPSVPHLHDAQG 522

  Fly   533 NEKVYSVAVKFDGED-MQIQVDNGDWQDAKVERVQDGSRL-------KIRANINSNVTTYN-ASI 588
            |  |.:|........ .|:.::.|..:.||..|..:|:.|       ..::.:.:.|.|:: |:|
Yeast   523 N--VINVTKSAPPSGWRQVLLEKGPSEFAKQVRQFNGTLLMDTTWRDAHQSLLATRVRTHDLATI 585

  Fly   589 DGTSVSLFSES------GKVDFEVGQPKFLSAQ-GDQLGAVGSRIVAPMPGILEKVLVKPGDKVK 646
            ..|:....:.:      |...|:|.. :||... .::|..:.|.:    |.|..::|::..:
Yeast   586 APTTAHALAGAFALECWGGATFDVAM-RFLHEDPWERLRKLRSLV----PNIPFQMLLRGAN--- 642

  Fly   647 KGENLAVLIAMKMEHILKAPKD----------------------ATIKSIGGA-------AGDNV 682
             |...:.|....::|.:|..||                      ..:|..||.       :||.:
Yeast   643 -GVAYSSLPDNAIDHFVKQAKDNGVDIFRVFDALNDLEQLKVGVNAVKKAGGVVEATVCYSGDML 706

  Fly   683 AKGAAV-ITFVDEEVEK 698
            ..|... :.:..|.|||
Yeast   707 QPGKKYNLDYYLEVVEK 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mccc1	NP_001247391.1	PccA	27..693	CDD:227111	244/725 (34%)
		CPSase_L_chain	27..135	CDD:278706	50/109 (46%)
		CPSase_L_D2	141..348	CDD:280881	93/209 (44%)
		Biotin_carb_C	362..469	CDD:214878	36/108 (33%)
		biotinyl_domain	626..691	CDD:133459	15/94 (16%)
PYC2	NP_009777.1	PycA	15..1171	CDD:223968	248/732 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1388
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860