DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mccc1 and DUR1,2

DIOPT Version :9

Sequence 1:	NP_001247391.1	Gene:	Mccc1 / 43750	FlyBaseID:	FBgn0039877	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_009767.1	Gene:	DUR1,2 / 852507	SGDID:	S000000412	Length:	1835	Species:	Saccharomyces cerevisiae

Alignment Length:	813	Identity:	248/813 - (30%)
Similarity:	373/813 - (45%)	Gaps:	169/813 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FGANARCFATEASPKVRPISKILISNRGEIACRVIRTARKLGVRTVAVFSDPDEKSMHTQLADES 73
            |.|.......:.|.|.:....:||:||||||.|:|:|.:|||:|:|||:||||:.|.|...||.|
Yeast   615 FRAYFEMLKKKESQKKKLFDTVLIANRGEIAVRIIKTLKKLGIRSVAVYSDPDKYSQHVTDADVS 679

  Fly    74 YRVGEAASSASYLRGERILDIAKRSGAQAIHPGYGFLSESVEFAELCQREGIIFMGPPSSAIRDM 138
            ..:....::.:||...:|:|.||::.||||.||||||||:.:|::.|...||.|:||....||.:
Yeast   680 VPLHGTTAAQTYLDMNKIIDAAKQTNAQAIIPGYGFLSENADFSDACTSAGITFVGPSGDIIRGL 744

  Fly   139 GIKSTSKAIMAAAGVPIINGYHGDDQSDECLQREADKIGFPLMIKAVRGGGGKGMRIAEKPDDFL 203
            |:|.:::.|...||||::.|.......:|. ::.|.::.:|:|:|:..||||.|::..:..:|..
Yeast   745 GLKHSARQIAQKAGVPLVPGSLLITSVEEA-KKVAAELEYPVMVKSTAGGGGIGLQKVDSEEDIE 808

  Fly   204 TALNSARTESEKSFGDSSVLLERYVRSPRHVEVQVFADQYGDAVYLWERDCSVQRRHQKIIEEAP 268
            ....:.:.:.|..|||:.|.|||::.:.||||||:..|.:|.|:.|.|||||:|||:||:|||.|
Yeast   809 HIFETVKHQGETFFGDAGVFLERFIENARHVEVQLMGDGFGKAIALGERDCSLQRRNQKVIEETP 873

  Fly   269 APGLSEDLRRELGEAAVRAAKAVGYVGAGTVEFILDKEDLSFHFMEMNTRLQVEHPITEMITGTD 333
            ||.|.|..|..|.:||......:.|..|||||||.|::...|:|:|:|||||||||||||:||.|
Yeast   874 APNLPEKTRLALRKAAESLGSLLNYKCAGTVEFIYDEKKDEFYFLEVNTRLQVEHPITEMVTGLD 938

  Fly   334 LVEWQIRIAAGEPLPLKQSEITRRGHAFEARIYAENPRGGFLPGAGPLRYLSTPQPSNNVRVETG 398
            ||||.|||||.:......:::...|.:.|||:|||||...|.|..|.|..:..|   :..||:|.
Yeast   939 LVEWMIRIAANDAPDFDSTKVEVNGVSMEARLYAENPLKNFRPSPGLLVDVKFP---DWARVDTW 1000

  Fly   399 VREGDEVSVHYDPMIAKLVVWGENRTQALNSLVARLGEYHISGLDTNINFLIDLASHPEFQLANV 463
            |::|..:|..|||.:||::|.|::|..|::.|...|.|..:.|..|||::|..:.:...|..|.|
Yeast  1001 VKKGTNISPEYDPTLAKIIVHGKDRDDAISKLNQALEETKVYGCITNIDYLKSIITSDFFAKAKV 1065

  Fly   464 HTGFIDEQFDTLFPPIIISPQQVSQAALALVLNELQAA----------FRNGNKDQDPFVATPNA 518
            .|.             |::..|....|:.:.|.....:          :|.|.....|..|....
Yeast  1066 STN-------------ILNSYQYEPTAIEITLPGAHTSIQDYPGRVGYWRIGVPPSGPMDAYSFR 1117

  Fly   519 RLNYSLVRRYDLKANEKVYS-----------VAV-------KFDGEDM----QIQVDNGDWQDAK 561
            ..|..:...|...|.|...:           :|:       ..||:::    .::|..|  ....
Yeast  1118 LANRIVGNDYRTPAIEVTLTGPSIVFHCETVIAITGGTALCTLDGQEIPQHKPVEVKRG--STLS 1180

  Fly   562 VERVQDGSR--LKIRANIN-------------SNVTTYNASI-------------DGTSV----- 593
            :.::..|.|  |.||..|:             .||..||..:             :..||
Yeast  1181 IGKLTSGCRAYLGIRGGIDVPKYLGSYSTFTLGNVGGYNGRVLKLGDVLFLPSNEENKSVECLPQ 1245

  Fly   594 -------------------------------------SLFSES---------------------- 599
                                                 ..|||.
Yeast  1246 NIPQSLIPQISETKEWRIGVTCGPHGSPDFFKPESIEEFFSEKWKVHYNSNRFGVRLIGPKPKWA 1310

  Fly   600 ---------------------GKVDFEVGQPKFLSAQGDQLGAVGSRIVAPMPGILEKVLVKPGD 643
                                 |.::|...:|..::..|..||....:.|.|...:.:...|||||
Yeast  1311 RSNGGEGGMHPSNTHDYVYSLGAINFTGDEPVIITCDGPSLGGFVCQAVVPEAELWKVGQVKPGD 1375

  Fly   644 KVKKGENLAVLIAMKMEHILKAPKDATIKSIGG 676
            .::     .|.::.:....||..:|..|||:.|
Yeast  1376 SIQ-----FVPLSYESSRSLKESQDVAIKSLDG 1403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mccc1	NP_001247391.1	PccA	27..693	CDD:227111	244/795 (31%)
		CPSase_L_chain	27..135	CDD:278706	52/107 (49%)
		CPSase_L_D2	141..348	CDD:280881	95/206 (46%)
		Biotin_carb_C	362..469	CDD:214878	40/106 (38%)
		biotinyl_domain	626..691	CDD:133459	15/51 (29%)
DUR1,2	NP_009767.1	allophanate_hyd	49..620	CDD:274265	2/4 (50%)
DUR1,2	NP_009767.1	urea_carbox	633..1832	CDD:274264	244/795 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	187	1.000	Domainoid score	I658
eggNOG	1	0.900	-	-		E1_COG4770
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	401	1.000	Inparanoid score	I313
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto99420
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18866
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2097
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.990