DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mccc1 and CAC2

DIOPT Version :9

Sequence 1:	NP_001247391.1	Gene:	Mccc1 / 43750	FlyBaseID:	FBgn0039877	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_001190422.1	Gene:	CAC2 / 833497	AraportID:	AT5G35360	Length:	555	Species:	Arabidopsis thaliana

Alignment Length:	444	Identity:	213/444 - (47%)
Similarity:	303/444 - (68%)	Gaps:	10/444 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KILISNRGEIACRVIRTARKLGVRTVAVFSDPDEKSMHTQLADESYRVGEAASSASYLRGERILD 93
            |||::||||||.||||||.::|:..|||:|..|:.::|.:||||:..:|||.|:.|||....:|.
plant    76 KILVANRGEIAVRVIRTAHEMGIPCVAVYSTIDKDALHVKLADEAVCIGEAPSNQSYLVIPNVLS 140

  Fly    94 IAKRSGAQAIHPGYGFLSESVEFAELCQREGIIFMGPPSSAIRDMGIKSTSKAIMAAAGVPIING 158
            .|...|...:|||||||||:..|.|:|:..||.|:||...:||.||.|:|::..|..||||.:.|
plant   141 AAISRGCTMLHPGYGFLSENALFVEMCRDHGINFIGPNPDSIRVMGDKATARETMKNAGVPTVPG 205

  Fly   159 YHGDDQSDECLQREADKIGFPLMIKAVRGGGGKGMRIAEKPDDFLTALNSARTESEKSFGDSSVL 223
            ..|..||.|...|.|::||||:||||..||||:|||:|::|.:|:..|..|::|:..:||:....
plant   206 SDGLLQSTEEAVRVANEIGFPVMIKATAGGGGRGMRLAKEPGEFVKLLQQAKSEAAAAFGNDGCY 270

  Fly   224 LERYVRSPRHVEVQVFADQYGDAVYLWERDCSVQRRHQKIIEEAPAPGLSEDLRRELGEAAVRAA 288
            ||::|::|||:|.||.||::|:.|:..|||||:|||:||::||||:|.|:.:||:.:|:|||.||
plant   271 LEKFVQNPRHIEFQVLADKFGNVVHFGERDCSIQRRNQKLLEEAPSPALTAELRKAMGDAAVAAA 335

  Fly   289 KAVGYVGAGTVEFILDKEDLSFHFMEMNTRLQVEHPITEMITGTDLVEWQIRIAAGEPLPLKQSE 353
            .::||:|.|||||:||:.. ||:|||||||:|||||:||||...||:|.|||:|.||.|..||.:
plant   336 ASIGYIGVGTVEFLLDERG-SFYFMEMNTRIQVEHPVTEMIYSVDLIEEQIRVAMGEKLRYKQED 399

  Fly   354 ITRRGHAFEARIYAENPRGGFLPGAGPL-RYLSTPQPSNNVRVETGVREGDEVSVHYDPMIAKLV 417
            |..|||:.|.||.||:|..||.||.|.: .||.:..|.  ||:::.|.....|...||.::.||:
plant   400 IVLRGHSIECRINAEDPFKGFRPGPGRITSYLPSGGPF--VRMDSHVYSDYVVPPSYDSLLGKLI 462

  Fly   418 VWGENRTQALNSLVARLGEYHISGLDTNINF---LIDLASHPEFQLANVHTGFI 468
            ||...|.:|:..:...|.:..|:|:.|.||:   ::|:   .:|:...|.|.||
plant   463 VWAPTREKAIERMKRALNDTIITGVPTTINYHKLILDV---EDFKNGKVDTAFI 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mccc1	NP_001247391.1	PccA	27..693	CDD:227111	213/444 (48%)
		CPSase_L_chain	27..135	CDD:278706	53/105 (50%)
		CPSase_L_D2	141..348	CDD:280881	111/206 (54%)
		Biotin_carb_C	362..469	CDD:214878	38/111 (34%)
		biotinyl_domain	626..691	CDD:133459
CAC2	NP_001190422.1	accC	73..521	CDD:129605	213/444 (48%)
		CPSase_L_chain	75..182	CDD:278706	53/105 (50%)
		CPSase_L_D2	187..394	CDD:280881	111/207 (54%)
		Biotin_carb_C	408..513	CDD:280880	36/109 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4770
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D254436at2759
OrthoFinder	1	1.000	-	-		FOG0004002
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100368
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720