DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mccc1 and Pcca

DIOPT Version :9

Sequence 1:	NP_001247391.1	Gene:	Mccc1 / 43750	FlyBaseID:	FBgn0039877	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	XP_038949590.1	Gene:	Pcca / 687008	RGDID:	3264	Length:	726	Species:	Rattus norvegicus

Alignment Length:	699	Identity:	272/699 - (38%)
Similarity:	410/699 - (58%)	Gaps:	49/699 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ATEASPKVRPISKILISNRGEIACRVIRTARKLGVRTVAVFSDPDEKSMHTQLADESYRVGEAAS 81
            :.|..||.:...||||:||||||||||:|.||:|:||||:.||.|..|:|.::|||:..||.|.:
  Rat    48 SVEYEPKEKTFDKILIANRGEIACRVIKTCRKMGIRTVAIHSDVDASSVHVKMADEAVCVGPAPT 112

  Fly    82 SASYLRGERILDIAKRSGAQAIHPGYGFLSESVEFAE--LCQ-REGIIFMGPPSSAIRDMGIKST 143
            |.|||..:.|::..|::||||:|||||||||:.|||:  .|| .|.:.|:||.:.||:.||.|..
  Rat   113 SKSYLNMDAIMEAIKKTGAQAVHPGYGFLSENKEFAKCLCCQAAEDVTFIGPDTHAIQAMGDKIE 177

  Fly   144 SKAIMAAAGVPIINGYHG-DDQSDECLQREADKIGFPLMIKAVRGGGGKGMRIAEKPDDFLTALN 207
            ||.:...|.|..|.|:.| ...:||.: |.|.:||:|:||||..||||||||||...::......
  Rat   178 SKLLAKRAKVNTIPGFDGVVKDADEAV-RIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFR 241

  Fly   208 SARTESEKSFGDSSVLLERYVRSPRHVEVQVFADQYGDAVYLWERDCSVQRRHQKIIEEAPAPGL 272
            .:..|:..||||..:|:|:::.:|||:|:||..|::|:|::|.||:||:|||:||::||||:..|
  Rat   242 FSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFL 306

  Fly   273 SEDLRRELGEAAVRAAKAVGYVGAGTVEFILDKEDLSFHFMEMNTRLQVEHPITEMITGTDLVEW 337
            ..:.||.:||.||..||||.|..||||||::|.:. :|:|:|||||||||||:||.|||.|||:.
  Rat   307 DPETRRAMGEQAVALAKAVKYSSAGTVEFLVDSQK-NFYFLEMNTRLQVEHPVTECITGLDLVQE 370

  Fly   338 QIRIAAGEPLPLKQSEITRRGHAFEARIYAENPRGGF-LPGAGPLRYLSTPQPSNNVRVETGVRE 401
            .|.:|.|.||..||.:|...|.|.|.|:|||:|...| ||..|.|.....|.....|||::|::.
  Rat   371 MILVAKGYPLRHKQEDIPISGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPIHLPGVRVDSGIQP 435

  Fly   402 GDEVSVHYDPMIAKLVVWGENRTQALNSLVARLGEYHISGLDTNINFLIDLASHPEFQLANVHTG 466
            |.::|::|||||:|||.:|.:|.:||..:...|..|.|.|:..||..|.::..:..|...::.|.
  Rat   436 GSDISIYYDPMISKLVTYGSDRAEALKRMEDALDSYVIRGVTHNIPLLREVIINTRFVKGDISTK 500

  Fly   467 FIDEQFDTLFPPIIISPQQVSQ----AALALVLNELQAAFRNGNKDQDPFVATPNARLNYSLVRR 527
            |:.:.:...|...:::|.:..|    |:...|.::|:|. |.....:.|.:....|:...|
  Rat   501 FLSDVYPDGFKGHMLTPSERDQLLAIASSLFVASQLRAQ-RFQEHSRVPVIRPDVAKWELS---- 560

  Fly   528 YDLKANEKVYSVAVKFDGEDMQIQVDNGDWQDAKVERVQDGSRLKIRANINSNVTTYNASIDGT- 591
              :|.:::.::|....:|....::|              |||:|.:.:..|......:.::|||
  Rat   561 --VKLHDEDHTVVASNNGPTFNVEV--------------DGSKLNVTSTWNLASPLLSVNVDGTQ 609

  Fly   592 -SVSLFSE--SGKVDFE----VGQPKFLSAQGDQLGA---------VGSRIVAPMPGILEKVLVK 640
             :|...|.  .|.:..:    |.:...|:....:|..         ..|.:.:||||::..|.||
  Rat   610 RTVQCLSRDAGGNMSIQFLGTVYKVHILTKLAAELNKFMLEKVPKDTSSTLCSPMPGVVVAVSVK 674

  Fly   641 PGDKVKKGENLAVLIAMKMEHILKAPKDATIKSIGGAAGDNVAKGAAVI 689
            |||.|.:|:.:.|:.||||::.:.|.|...:|.:...|||.|.:|..::
  Rat   675 PGDMVAEGQEICVIEAMKMQNSMTAGKMGKVKLVHCKAGDTVGEGDLLV 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mccc1	NP_001247391.1	PccA	27..693	CDD:227111	269/689 (39%)
		CPSase_L_chain	27..135	CDD:278706	61/110 (55%)
		CPSase_L_D2	141..348	CDD:280881	103/207 (50%)
		Biotin_carb_C	362..469	CDD:214878	40/107 (37%)
		biotinyl_domain	626..691	CDD:133459	25/64 (39%)
Pcca	XP_038949590.1	PccA	58..726	CDD:227111	269/689 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130620at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100368
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820