DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mccc1 and ACC

DIOPT Version :9

Sequence 1:	NP_001247391.1	Gene:	Mccc1 / 43750	FlyBaseID:	FBgn0039877	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_610342.1	Gene:	ACC / 35761	FlyBaseID:	FBgn0033246	Length:	2482	Species:	Drosophila melanogaster

Alignment Length:	730	Identity:	221/730 - (30%)
Similarity:	337/730 - (46%)	Gaps:	134/730 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RPISKILISNRGEIACRVIRTARK---------LGVRTVAVFSDPDEK--SMHTQLADESYRVGE 78
            |.|:|:||:|.|..|.:.:|:.|:         ..:|.|.:.:..|.|  :.:.::||....|..
  Fly   258 RVINKVLIANNGIAAVKCMRSIRRWAYEMFKNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPG 322

  Fly    79 AASSASYLRGERILDIAKRSGAQAIHPGYGFLSESVEFAELCQREGIIFMGPPSSAIRDMGIKST 143
            .:::.:|...|.|:|||.|:..||:..|:|..||:.:..||..:||::|:|||..|:..:|.|..
  Fly   323 GSNNNNYANVELIVDIALRTQVQAVWAGWGHASENPKLPELLHKEGLVFLGPPERAMWALGDKVA 387

  Fly   144 SKAIMAAAGVPIINGYHGDDQ-----------SDECLQR-----------EADKIGFPLMIKAVR 186
            |..:...|.:|.: .:.|.|.           |.|...|           ..:|||||:||||..
  Fly   388 SSIVAQTAEIPTL-PWSGSDLKAQYSGKKIKISSELFARGCVTNVEQGLAAVNKIGFPVMIKASE 451

  Fly   187 GGGGKGMRIAEKPDDFLTALNSARTESEKSFGDSSVLLERYVRSPRHVEVQVFADQYGDAVYLWE 251
            ||||||:|..:..::|.......:.|    ...|.:.:.:..|..||:|||:.|||||:|:.|:.
  Fly   452 GGGGKGIRRVDTTEEFPGLFRQVQAE----VPGSPIFVMKLARGARHLEVQLLADQYGNAISLFG 512

  Fly   252 RDCSVQRRHQKIIEEAPA----PGLSEDLRRELGEAAVRAAKAVGYVGAGTVEFILDKEDLSFHF 312
            ||||:|||||||||||||    |.:.||:.:    ||||.||.||||.|||||::.|.|...| |
  Fly   513 RDCSIQRRHQKIIEEAPAIVAQPEVFEDMEK----AAVRLAKMVGYVSAGTVEYLYDPEGRYF-F 572

  Fly   313 MEMNTRLQVEHPITEMITGTDLVEWQIRIAAGEPL-------------PLKQSEI---------T 355
            :|:|.|||||||.|||:...:|...|::|..|.||             |...|.|         .
  Fly   573 LELNPRLQVEHPCTEMVADVNLPAAQLQIGMGIPLYRLKDIRLLYGESPWGSSVIDFENPPNKPR 637

  Fly   356 RRGHAFEARIYAENPRGGFLPGAGPLRYLSTPQPSN-----NVRVETGVREGDEVSVHYDPMIAK 415
            ..||...|||.:|||..||.|.:|.::.|:.....|     :|....|:.|      ..|.....
  Fly   638 PSGHVIAARITSENPDEGFKPSSGTVQELNFRSSKNVWGYFSVAASGGLHE------FADSQFGH 696

  Fly   416 LVVWGENRTQALNSLVARLGEYHISG-LDTNINFLIDLASHPEFQLANVHTGFID----EQFDTL 475
            ...|||||.||..:||..|.|..|.| ..|.:.:||.|.....|...::.|.::|    |:..:.
  Fly   697 CFSWGENRQQARENLVIALKELSIRGDFRTTVEYLITLLETNRFLDNSIDTAWLDALIAERVQSE 761

  Fly   476 FPPII---------ISPQQVSQAALALVLNELQAAFRNGNKDQDPFVATPNARLNYSLVRRYDLK 531
            .|.|:         |:.:|::::     .:..|.:...|.      :...|     :|....|::
  Fly   762 KPDILLGVMCGSLHIADRQITES-----FSSFQTSLEKGQ------IQAAN-----TLTNVVDVE 810

  Fly   532 -ANEKV-YSVAVKFDGEDMQIQVDNGDWQDAKVERVQDGSRLKIRANINSNVTTYNASIDGTSVS 594
             .|:.: |.|.....|.:....:.|..:::.:|.|:.||..|              .|::|.|.:
  Fly   811 LINDGIRYKVQAAKSGANSYFLLMNSSFKEIEVHRLSDGGLL--------------ISLEGASYT 861

  Fly   595 LF--SESGKVDFEVG-QPKFLSAQGDQLGAVGSRIVAPMPGILEKVLVKPGDKVKKGENLAVLIA 656
            .:  .|..:....:| |......:.|.     |.:.:|..|.|..::|:.|..|.||:..|.:..
  Fly   862 TYMKEEVDRYRIVIGNQTCVFEKENDP-----SLLRSPSAGKLINMIVEDGAHVSKGQAYAEIEV 921

  Fly   657 MKMEHILKAPKDATI 671
            |||...|.:.:..|:
  Fly   922 MKMVMTLTSQEAGTV 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mccc1	NP_001247391.1	PccA	27..693	CDD:227111	220/728 (30%)
		CPSase_L_chain	27..135	CDD:278706	37/118 (31%)
		CPSase_L_D2	141..348	CDD:280881	98/245 (40%)
		Biotin_carb_C	362..469	CDD:214878	35/112 (31%)
		biotinyl_domain	626..691	CDD:133459	14/46 (30%)
ACC	NP_610342.1	AccC	260..757	CDD:223516	178/512 (35%)
		CPSase_L_chain	260..379	CDD:278706	37/118 (31%)
		ATP-grasp_4	384..607	CDD:302634	96/232 (41%)
		Biotin_carb_C	644..751	CDD:280880	35/112 (31%)
		biotinyl_domain	891..952	CDD:133459	14/46 (30%)
		ACC_central	956..1700	CDD:285519
		Carboxyl_trans	1800..2344	CDD:279390
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438210
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D24048at6960
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.850