DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mccc1 and pyr1

DIOPT Version :9

Sequence 1:	NP_001247391.1	Gene:	Mccc1 / 43750	FlyBaseID:	FBgn0039877	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_595900.1	Gene:	pyr1 / 2539661	PomBaseID:	SPBC17G9.11c	Length:	1185	Species:	Schizosaccharomyces pombe

Alignment Length:	685	Identity:	231/685 - (33%)
Similarity:	345/685 - (50%)	Gaps:	84/685 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 YARLLRNFGANARCFA---TEASPKVRPISKILISNRGEIACRVIRTARKLGVRTVAVFSDPDEK 63
            |..||.|...|...|:   ..:|......:|:|::||.|||.||.|||.:|.:.|||::|..|..
pombe     5 YDALLHNQSTNTNPFSKLQDRSSLLGEKFTKVLVANRSEIAIRVFRTAHELSMHTVAIYSYEDRL 69

  Fly    64 SMHTQLADESY---RVGEAASSASYLRGERILDIAKRSGAQAIHPGYGFLSESVEFAELCQREGI 125
            |||.|.|||||   :||:.:...:||..:.|:.||||:||..:|||||||||:.|||......|:
pombe    70 SMHRQKADESYPIGKVGQYSPVGAYLAIDEIVSIAKRTGANLVHPGYGFLSENAEFARKVNEAGM 134

  Fly   126 IFMGPPSSAIRDMGIKSTSKAIMAAAGVPIINGYHGDDQSDECLQREADKIGFPLMIKAVRGGGG 190
            .|:||....|..:|.|:.::||....|||::.|..|..:..|..:....:.|.|::|||..||||
pombe   135 QFVGPSPEVIDSLGDKTKARAIAIRCGVPVVPGTPGPVEHYEEAEAFVKEYGLPVIIKAAMGGGG 199

  Fly   191 KGMRIAEKPDDFLTALNSARTESEKSFGDSSVLLERYVRSPRHVEVQVFADQYGDAVYLWERDCS 255
            :|||:....|....:...||:|:..||||.:|.:||::..|:|:|:|:.||:.|:.::|.|||||
pombe   200 RGMRVVRSADTLKESFERARSEALASFGDGTVFIERFLDKPKHIEIQLMADKAGNVIHLHERDCS 264

  Fly   256 VQRRHQKIIEEAPAPGLSEDLRRELGEAAVRAAKAVGYVGAGTVEFILDKEDLSFHFMEMNTRLQ 320
            |||||||::|.|||..|...:|:.|.:.|::.||.|.|..|||.||:||::. ..:|:|:|.|:|
pombe   265 VQRRHQKVVEIAPAKDLDPKIRQALYDDAIKIAKEVKYCNAGTAEFLLDQKG-RHYFIEINPRIQ 328

  Fly   321 VEHPITEMITGTDLVEWQIRIAAGEPLP---LKQSEITRRGHAFEARIYAENPRGGFLPGAGPLR 382
            |||.|||.|||.|:|..|:.:|||..||   |.|.:|:.||.|.:.|:..|:|..||.|..|.:.
pombe   329 VEHTITEEITGVDIVSAQLHVAAGFTLPEIGLTQDKISTRGFAIQCRVTTEDPNNGFAPDIGKIE 393

  Fly   383 -YLSTPQPSNNVRVETGVR--EGDEVSVHYDPMIAKLVVWGENRTQALNSLVARLGEYHISGLDT 444
             |.|.  ..|.||:: |..  .|..::.|||.|:.|..............::..|.|:.:.|:.|
pombe   394 VYRSA--GGNGVRLD-GANGFAGSVITPHYDSMLVKCTCHDATYEYTRRKMIRSLIEFRVRGVKT 455

  Fly   445 NINFLIDLASHPEFQLANVHTGFIDEQFDTLFPPIIISPQQVSQAALALVLNELQAAFRNGNKDQ 509
            ||.|::.|..|..|...|..|.|||:           :|             ||...:|:.|:.|
pombe   456 NIPFVLRLLMHDTFIQGNCWTTFIDD-----------TP-------------ELFQLYRSRNRAQ 496

  Fly   510 DPFVATPNARLNYSLVRRYD----LKANEKVYSVAVKFDGEDMQIQ-----------VDNG---- 555
            .......:..:|.|.::..:    || :|.|..|.:...|..:.:.           :|||
pombe   497 KLLAYLGDLAVNGSSIKGQNGEPALK-SEIVMPVLLDSTGNQIDVSHPSEKGWRKLLLDNGPAAF 560

  Fly   556 ---------------DWQDAKVERVQDGSRLKIRANINSNVTTYNASIDGTSVSLFSESGKVDFE 605
                           .|:||.    |.....::|.....|:..|.:....::.|| ...|...|:
pombe   561 AKAVRNHKRGLIMDTTWRDAH----QSLLATRVRTIDLVNIAPYTSHALASAYSL-EMWGGATFD 620

  Fly   606 VGQPKFLSAQGDQLGAVGSRIVAPMPGILEKVLVK 640
            |..........|:|    .|:...:|.|..::|::
pombe   621 VSMRFLHECPWDRL----RRLRKLVPNIPFQMLLR 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mccc1	NP_001247391.1	PccA	27..693	CDD:227111	224/657 (34%)
		CPSase_L_chain	27..135	CDD:278706	54/110 (49%)
		CPSase_L_D2	141..348	CDD:280881	91/206 (44%)
		Biotin_carb_C	362..469	CDD:214878	32/109 (29%)
		biotinyl_domain	626..691	CDD:133459	3/15 (20%)
pyr1	NP_595900.1	PycA	27..1184	CDD:223968	225/663 (34%)
		CPSase_L_chain	33..144	CDD:278706	54/110 (49%)
		ATP-grasp_4	149..356	CDD:302634	91/207 (44%)
		Biotin_carb_C	373..480	CDD:214878	32/109 (29%)
		DRE_TIM_PC_TC_5S	572..854	CDD:163675	18/89 (20%)
		PYC_OADA	865..1064	CDD:280576
		biotinyl_domain	1116..1182	CDD:133459
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910