DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mccc1 and Pcca

DIOPT Version :9

Sequence 1:	NP_001247391.1	Gene:	Mccc1 / 43750	FlyBaseID:	FBgn0039877	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_659093.2	Gene:	Pcca / 110821	MGIID:	97499	Length:	724	Species:	Mus musculus

Alignment Length:	696	Identity:	266/696 - (38%)
Similarity:	407/696 - (58%)	Gaps:	46/696 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ATEASPKVRPISKILISNRGEIACRVIRTARKLGVRTVAVFSDPDEKSMHTQLADESYRVGEAAS 81
            :.|..||.:...||||:||||||||||:|.:|:|::|||:.||.|..|:|.::|||:..||.|.:
Mouse    49 SVEYEPKEKTFDKILIANRGEIACRVIKTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPT 113

  Fly    82 SASYLRGERILDIAKRSGAQAIHPGYGFLSESVEFAELCQREGIIFMGPPSSAIRDMGIKSTSKA 146
            |.|||..:.|::..|::.|||:|||||||||:.|||:....|.:.|:||.:.||:.||.|..||.
Mouse   114 SKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFAKRLAAEDVTFIGPDTHAIQAMGDKIESKL 178

  Fly   147 IMAAAGVPIINGYHG-DDQSDECLQREADKIGFPLMIKAVRGGGGKGMRIAEKPDDFLTALNSAR 210
            :...|.|..|.|:.| ...:||.: |.|.:||:|:||||..||||||||||...::.......:.
Mouse   179 LAKRAKVNTIPGFDGVVKDADEAV-RIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRFSS 242

  Fly   211 TESEKSFGDSSVLLERYVRSPRHVEVQVFADQYGDAVYLWERDCSVQRRHQKIIEEAPAPGLSED 275
            .|:..||||..:|:|:::.:|||:|:||..|::|:|::|.||:||:|||:||::||||:..|..:
Mouse   243 QEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDPE 307

  Fly   276 LRRELGEAAVRAAKAVGYVGAGTVEFILDKEDLSFHFMEMNTRLQVEHPITEMITGTDLVEWQIR 340
            .|:.:||.||..||||.|..||||||::|.:. :|:|:|||||||||||:||.|||.|||:..|.
Mouse   308 TRQAMGEQAVALAKAVKYSSAGTVEFLVDSQK-NFYFLEMNTRLQVEHPVTECITGLDLVQEMIL 371

  Fly   341 IAAGEPLPLKQSEITRRGHAFEARIYAENPRGGF-LPGAGPLRYLSTPQPSNNVRVETGVREGDE 404
            :|.|.||..||.:|...|.|.|.|:|||:|...| ||..|.|.....|.....|||::|::.|.:
Mouse   372 VAKGYPLRHKQEDIPISGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPIHLPGVRVDSGIQPGSD 436

  Fly   405 VSVHYDPMIAKLVVWGENRTQALNSLVARLGEYHISGLDTNINFLIDLASHPEFQLANVHTGFID 469
            :|::|||||:|||.:|.:|.:||..:...|..|.|.|:..||..|.::..:..|...::.|.|:.
Mouse   437 ISIYYDPMISKLVTYGSDRAEALKRMEDALDNYVIRGVTHNIPLLREVIINTRFVKGDISTKFLS 501

  Fly   470 EQFDTLFPPIIISPQQVSQ----AALALVLNELQAAFRNGNKDQDPFVATPNARLNYSLVRRYDL 530
            :.:...|....::..:.:|    |:...|.::|:|. |.....:.|.:....|:...|      :
Mouse   502 DVYPDGFKGHTLTLSERNQLLAIASSVFVASQLRAQ-RFQEHSRVPVIRPDVAKWELS------V 559

  Fly   531 KANEKVYSVAVKFDGEDMQIQVDNGDWQDAKVERVQDGSRLKIRANINSNVTTYNASIDGTSVS- 594
            |.:::.::|....:|....::|              |||:|.:.:..|......:.::|||..:
Mouse   560 KLHDEDHTVVASNNGPAFTVEV--------------DGSKLNVTSTWNLASPLLSVNVDGTQRTV 610

  Fly   595 --LFSESG---KVDF--EVGQPKFLSAQGDQLGA---------VGSRIVAPMPGILEKVLVKPGD 643
              |..|:|   .:.|  .|.:...|:....:|..         ..|.:.:||||::..|.|||||
Mouse   611 QCLSREAGGNMSIQFLGTVYKVHILTKLAAELNKFMLEKVPKDTSSTLCSPMPGVVVAVSVKPGD 675

  Fly   644 KVKKGENLAVLIAMKMEHILKAPKDATIKSIGGAAGDNVAKGAAVI 689
            .|.:|:.:.|:.||||::.:.|.|...:|.:...|||.|.:|..::
Mouse   676 MVAEGQEICVIEAMKMQNSMTAGKMGKVKLVHCKAGDTVGEGDLLV 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mccc1	NP_001247391.1	PccA	27..693	CDD:227111	263/686 (38%)
		CPSase_L_chain	27..135	CDD:278706	56/107 (52%)
		CPSase_L_D2	141..348	CDD:280881	102/207 (49%)
		Biotin_carb_C	362..469	CDD:214878	40/107 (37%)
		biotinyl_domain	626..691	CDD:133459	25/64 (39%)
Pcca	NP_659093.2	PccA	59..724	CDD:227111	263/686 (38%)
		CPSase_L_chain	59..167	CDD:278706	56/107 (52%)
		CPSase_L_D2	172..379	CDD:280881	102/208 (49%)
		Biotin_carb_C	393..500	CDD:214878	39/106 (37%)
		biotinyl_domain	657..723	CDD:133459	25/65 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4770
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130620at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100368
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2097
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750