Protein Alignment faf and USP10

DIOPT Version :10

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: NP_001259004.1
• Gene: USP10 / 9100
• HGNCID: 12608
• Length: 802
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 115/524 - (21%)
• Similarity: 174/524 - (33%)
• Gaps: 179/524 - (34%)

  Fly  1606 PVCRSPHTIAAACDLLIALCQLCVPNMKLLTN-TLIDFVCTDTDPLREWDYLPPVGARPTKGFCG 1669
            ||...|..|..|               :||.| |||.               .||..:|.    |
Human   390 PVSEDPVAIKIA---------------ELLENVTLIH---------------KPVSLQPR----G 420

  Fly  1670 LKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGEDFSGDSDLTGGGLGSALFSGPASALV 1734
            |.|.|..||:|:.||.|...|.                             :...:...|..:.|
Human   421 LINKGNWCYINATLQALVACPP-----------------------------MYHLMKFIPLYSKV 456

  Fly  1735 SLPSSSSTIEDGLHDVRKNY--HVVILKHVQAIFAHL------GHSALQYYVPRGLWTHFKLLGE 1791
            ..|.:|:.:.|....:...:  ..|..|..||:...:      |.:....|:.|.|..:...|.|
Human   457 QRPCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIRPGAAFEPTYIYRLLTVNKSSLSE 521

  Fly  1792 PVNLREQQDAVEFFMSLLESLDE---GLKALGQPQLMNATLGGSFSDQKICQE------------ 1841
            .   ..|:||.|:...:|..|.|   .||.|..|.....|:.....:..:.:|
Human   522 K---GRQEDAEEYLGFILNGLHEEMLNLKKLLSPSNEKLTISNGPKNHSVNEEEQEEQGEGSEDE 583

  Fly  1842 --------------------CP--------------HRYSKE----EPFSVFSVDIRNHS--SLT 1866
                                .|              .:.|||    :||....:||::..  ::.
Human   584 WEQVGPRNKTSVTRQADFVQTPITGIFGGHIRSVVYQQSSKESATLQPFFTLQLDIQSDKIRTVQ 648

  Fly  1867 ESLEQYVKGELLEGADAYHCDKCDKKVVTVKRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDYF 1931
            ::||..|..|.::|    :..|..::|...:||.::||||||.:.||||.|:....|. |.....
Human   649 DALESLVARESVQG----YTTKTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQ-KLIKNI 708

  Fly  1932 EFPRILDMEPYTVSGLAKLEGEVVEVG-DNCQTNVETTKYELTGIVVHSG-QASGGHYFSYILSK 1994
            |:|  :|:|         :..|::..| .|.......| |.|..:|.|.| .|:||||.:.:...
Human   709 EYP--VDLE---------ISKELLSPGVKNKNFKCHRT-YRLFAVVYHHGNSATGGHYTTDVFQI 761

  Fly  1995 NPANGKCQWYKFDDGEVTECKMHEDEEMKAECFGGEYMGETYDNNLKRMQYRRQKRWWNAYMLFY 2059
            . .||   |.:.||..|.....::..:..||                          ..||:|:|
Human   762 G-LNG---WLRIDDQTVKVINQYQVVKPTAE--------------------------RTAYLLYY 796

  Fly  2060 TRCD 2063
            .|.|
Human   797 RRVD 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	Ubl1_cv_Nsp3_N-like	<994..1060	CDD:475130
		peptidase_C19C	1666..2064	CDD:239124	101/463 (22%)
		DUF3517	2198..2566	CDD:463438
USP10	NP_001259004.1	UCH	419..796	CDD:425685	98/459 (21%)