Protein Alignment faf and USP13

DIOPT Version :10

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: NP_003931.2
• Gene: USP13 / 8975
• HGNCID: 12611
• Length: 863
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 129/646 - (19%)
• Similarity: 214/646 - (33%)
• Gaps: 214/646 - (33%)

  Fly  1384 LGNSSGDFEDE---VIVPDGQDFSMCK----EALEVLTISFILNPSANEALTSDPN-W------P 1434
            |.:...::|||   ||.||..:.::..    .||..:....:|: |.:.....||: |      .
Human   126 LNSDDYEYEDEAKLVIFPDHYEIALPNIEELPALVTIACDAVLS-SKSPYRKQDPDTWENELPVS 189

  Fly  1435 KFITSIV-LKNPLRHVRQVASEQLFLASTYCAG-DRRPFVYMVNLLVGALKTLVPQYESTCAEFF 1497
            |:..::. |.|.:|         :..:...||. |.|..::: ||..|
Human   190 KYANNLTQLDNGVR---------IPPSGWKCARCDLRENLWL-NLTDG----------------- 227

  Fly  1498 SVLC------------RTLSYGCIYNWPLQISEGLL---GDEIKWLQRIRENVHATGDTQVHEEL 1547
            ||||            ..|.:.....:||.:..|.:   |.::...|.             .|.:
Human   228 SVLCGKWFFDSSGGNGHALEHYRDMGYPLAVKLGTITPDGADVYSFQE-------------EEPV 279

  Fly  1548 LEGHLCLAKELMFFLGADSKAQLNELIHELIDDFLFTASREFLHLRRHGSLR--QDTVPPPVCRS 1610
            |:.|  |||.|..| |.|                       .||:  ||:..  ||.
Human   280 LDPH--LAKHLAHF-GID-----------------------MLHM--HGTENGLQDN-------- 308

  Fly  1611 PHTIAAACDLLIALCQLCVPNMKLLTNTLIDFVCTDTDPLREWDYLPPVGA--RPT--KGFCGLK 1671
                                ::||..:              ||:.:...|.  :|.  .|:.|||
Human   309 --------------------DIKLRVS--------------EWEVIQESGTKLKPMYGPGYTGLK 339

  Fly  1672 NAGATCYMNSVLQQLYMVPAVR---VGIL-RAHGAATTD-GEDFSGDSDLTGGGLGSALFSGPAS 1731
            |.|.:||::||:|.::.:|..:   ||.| |....:..| .:||:......|.||.|..:|.|
Human   340 NLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYSPLDPTQDFNTQMTKLGHGLLSGQYSKP-- 402

  Fly  1732 ALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGHSALQYYVPRGLWTHFKLLGEPVNLR 1796
                 |..|..||..:.:..|.....|...:...|....|...                   :..
Human   403 -----PVKSELIEQVMKEEHKPQQNGISPRMFKAFVSKSHPEF-------------------SSN 443

  Fly  1797 EQQDAVEFFMSLLESLDEGLKALGQPQLMNATLGGSFSDQKI--CQECPHRYSK----------- 1848
            .||||.|||:.|:..::........|..:...|    .:::|  ||....||::
Human   444 RQQDAQEFFLHLVNLVERNRIGSENPSDVFRFL----VEERIQCCQTRKVRYTERVDYLMQLPVA 504

  Fly  1849 ------EEPFSVFSVDIRNHSSLTESLEQYVKGEL-----------LEGADAYHCDKCDKKVVTV 1896
                  ::....:.:..|...:....|.:.|:.::           .|..|.:.......|...|
Human   505 MEAATNKDELIAYELTRREAEANRRPLPELVRAKIPFSACLQAFSEPENVDDFWSSALQAKSAGV 569

  Fly  1897 KRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDYFEFPRILDMEPYTVSGLAKLEGEVVEV 1957
            |.......|..|.:|:|:|.:..:.| ..||:...:.|.:||:......||...|.|:.::
Human   570 KTSRFASFPEYLVVQIKKFTFGLDWV-PKKFDVSIDMPDLLDINHLRARGLQPGEEELPDI 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	Ubl1_cv_Nsp3_N-like	<994..1060	CDD:475130
		peptidase_C19C	1666..2064	CDD:239124	71/327 (22%)
		DUF3517	2198..2566	CDD:463438
USP13	NP_003931.2	zf-UBP_var	35..98	CDD:407678
		zf-UBP	211..284	CDD:460464	20/105 (19%)
		Peptidase_C19B	337..859	CDD:239123	70/324 (22%)
		UBA1_UBP13	652..700	CDD:270567
		UBA2_UBP5	728..769	CDD:270569