Protein Alignment faf and UBP12

DIOPT Version :10

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: NP_012338.1
• Gene: UBP12 / 853242
• SGDID: S000003733
• Length: 1254
• Species: Saccharomyces cerevisiae
• Alignment Length: 1425
• Identity: 275/1425 - (19%)
• Similarity: 455/1425 - (31%)
• Gaps: 529/1425 - (37%)

  Fly   838 MLDNEDLIGKDYLWRVITTGGEEIASKAIDLLKEVSTALGPRLQENIAEFHEMFIGECCSRLRTH 902
            :||::|.|.::    .:.....||.....|.....|.|   ...|.|||.|        :...|:
Yeast    38 VLDDKDEIKQE----SVPVSDREIEDTESDASAVSSFA---SANELIAEPH--------AASETN 87

  Fly   903 YGNIVILGKTQLQEELDAPDQSDNTNDESKDSKMRFIEAEKMCRILKVLQEYVKECDRSFSGDRV 967
            .|.....|:..|:::.|...:....|.|::.      |.:|:|.:.||
Yeast    88 LGTNGQDGRNVLEQQRDVVARLIEENKETQK------EGDKVCIVPKV----------------- 129

  Fly   968 HLPLSRVTRGKNTILYIRFQNPGRSIDDMEIVTHSNETMAA--FKRNLLKRIKGTSTANIKVDLF 1030
                          .|.:|.:|  .:.|.|.:...|..|..  |:..:|:........:|...:|
Yeast   130 --------------WYDKFFDP--DVTDPEDIGPINTRMICRDFENFVLEDYNRCPYLSIAEPVF 178

  Fly  1031 YANDEMIGVSDEINPLYQYTIRDKMNLTAKLTPVGTGLASSPDSSSDSSTGSPPRPCPDMQRVES 1095
            ....|:.|                  :|:...||.|.|.      .:.:||          .:|:
Yeast   179 NFLSEIYG------------------MTSGSYPVVTNLV------INQTTG----------ELET 209

  Fly  1096 ESTLPGVIISQNYQYTEFFLKLYQLGSDLEHGRLR-----DSAKVLLHLLPCDRQTIRQLKIMCK 1155
            |             |.::|.:|:.| ::.:.||.|     ||   :::|.......:|.|
Yeast   210 E-------------YNKWFFRLHYL-TEKQDGRKRRHGQDDS---IMYLSMSALNLVRDL----- 252

  Fly  1156 VPKA--------------AVTVAV----TGDKIAKDEEEKLYPTEQAGIEDEEEHCTPEQMFLHP 1202
            |.|:              ||...:    .|..||.|.....:......|       ||.|....|
Yeast   253 VEKSMNLFFEKADHLDVNAVDFKIWFVSEGSDIATDSNVSTFLNSSYEI-------TPLQFLELP 310

  Fly  1203 TPAQVLYNLSVLHGLLIP-----ALDPL--GESALLVQSAWMHSGCAHFVLELLTKNNFLPSA-- 1258
                       :..||||     .||.:  ..|.|:::...: .|..|:.......|...|::
Yeast   311 -----------IKKLLIPDMFENRLDKITSNPSDLVIEIKPI-EGNHHWPSNYFAYNKLEPASGT 363

  Fly  1259 -------DMHTKRASFQCVLRLAKL---FLYIVGSVLSRVGDE-PM---------ICDL-DNGSR 1302
                   :.....::.||::.:.:|   |||  ......:.:| |:         ..|| ....:
Yeast   364 TGLVNLGNTCYMNSALQCLVHIPQLRDYFLY--DGYEDEINEENPLGYHGYVARAFSDLVQKLFQ 426

  Fly  1303 SQVDILKQNFSTMPSSSQGT-----------------------LRAISAKLAVILAREML---SA 1341
            :::.|:::|.:..||..:.|                       |.::...|..|:.:|..   |.
Yeast   427 NRMSIMQRNAAFPPSMFKSTIGHFNSMFSGYMQQDSQEFLAFLLDSLHEDLNRIIKKEYTEKPSL 491

  Fly  1342 SPEGDRCRTLFSSTLQWSCPDISTIKAVVQLAW----ASSCGNLQALGNSSGDFEDEVIVPDGQD 1402
            ||..|             ..|.:.:|.:....|    ..:|..:..|  ..|.::..:..|:.|:
Yeast   492 SPGDD-------------VNDWNVVKKLADDTWEMHLKRNCSVITDL--FVGMYKSTLYCPECQN 541

  Fly  1403 FSMCKEALEVLTISFILNPSANEALTSDPNWPKFITSIVLKNP--LRHVRQVASEQLFLASTYCA 1465
            .|:..:....:|:          .|..|..|.|.|....:.:|  |..|      :|..:|||.
Yeast   542 VSITFDPYNDVTL----------PLPVDTVWDKTIKIFPMNSPPLLLEV------ELSKSSTYM- 589

  Fly  1466 GDRRPFVYMV-----NLLVGA---LKTLVPQYEST--CAEFFSV--LCRTLSYGCIYNWPLQISE 1518
             |.:.:|..:     |.|.|.   ...:...||||  .|:|.::  |.:.......|..|:
Yeast   590 -DLKNYVGKMSGLDPNTLFGCEIFSNQIYVNYESTESNAQFLTLQELIKPADDVIFYELPV---- 649

  Fly  1519 GLLGDEIKWLQRIRENVHATGDTQVHEELLEGHLCLAKELMFFLGADSKAQLNELIHELIDDFLF 1583
                               |.|.:|...:|...:             .|...|.::..:  .|..
Yeast   650 -------------------TNDNEVIVPVLNTRI-------------EKGYKNAMLFGV--PFFI 680

  Fly  1584 TASREFLHLRRHGSLRQD-------------TVPPPVCRSPHTIAAACDLLIALCQLCVPNMK-- 1633
            |...:  .|...|::|..             ..|.|| .:....|.|..||:..    .|:::
Yeast   681 TLKED--ELNNPGAIRMKLQNRFVHLSGGYIPFPEPV-GNRTDFADAFPLLVEK----YPDVEFE 738

  Fly  1634 ----LLTNTLIDFVCTDTDPLREWDYLPPVGARPTKGFCGLKNAGATCYMNSVLQQLYMVPAVRV 1694
                :|..|.|.  .||.|                |.|..:|
Yeast   739 QYKDILQYTSIK--VTDKD----------------KSFFSIK----------------------- 762

  Fly  1695 GILRAHGAATTDGEDFSGDSDLTGGGLGSALFSGPASALVSLPSSSSTIEDGLHDVRK---NYHV 1756
             ||      :.:.|.....::.||..     |..|.|.| :| ..::.|:|.|.||.|   ||..
Yeast   763 -IL------SVEKEQQFASNNRTGPN-----FWTPISQL-NL-DKATDIDDKLEDVVKDIYNYSS 813

  Fly  1757 V------ILKHVQAIFAHLGHSALQYYVP---------RGLWTHFKLLGEPVNLREQQDAVEFFM 1806
            :      :|..|.......|..|..:..|         :...|:    .|.||....:|.   .|
Yeast   814 LVDCAEGVLMQVDDEGDTEGSEAKNFSKPFQSGDDEENKETVTN----NENVNNTNDRDE---DM 871

  Fly  1807 SLLESLDEGLKALGQPQL-----------------------MN-------ATLGG--SFSDQKIC 1839
            .|.:.::|  .|..:|:|                       ||       :.||.  :|||.||
Yeast   872 ELTDDVEE--DASTEPELTDKPEALDKIKDSLTSTPFAILSMNDIIVCEWSELGSNEAFSDDKI- 933

  Fly  1840 QECPHRYSKEEPFSVFSVDIRNHS-----------SLTESLEQYVKGELLEGADAYHCDKCDKKV 1893
                  |:.|.|.::.:.::.|..           :|.:.|:.:.|.|:|...|:::|..|.:..
Yeast   934 ------YNWENPATLPNKELENAKLERSNAKERTITLDDCLQLFSKPEILGLTDSWYCPTCKEHR 992

  Fly  1894 VTVKRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDYFEFP-RILDMEPYTV-----SGLAKLEG 1952
            ...|::.:...|.:|.|.|||||  .:|..:.|.:....|| ..||:..|.|     .||.
Yeast   993 QATKQIQLWNTPDILLIHLKRFE--SQRSFSDKIDATVNFPITDLDLSRYVVYKDDPRGLI---- 1051

  Fly  1953 EVVEVGDNCQTNVETTKYELTGIVVHSGQASGGHYFSYILSKNPANGKCQWYKFDDGEVTE---- 2013
                             |:|..:..|.|...||||.:|:  ||.|:.|  ||.|||..|||
Yeast  1052 -----------------YDLYAVDNHYGGLGGGHYTAYV--KNFADNK--WYYFDDSRVTETAPE 1095

  Fly  2014 ------------CKMHEDEEMKAECFGGEYMGET------------YDNNLKRMQYRRQK 2049
                        .:.|:|         |..:|.:            ||..:|::...:.|
Yeast  1096 NSIAGSAYLLFYIRRHKD---------GNGLGSSKLQEIIQKSRHGYDERIKKIYDEQMK 1146

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	Ubl1_cv_Nsp3_N-like	<994..1060	CDD:475130	11/67 (16%)
		peptidase_C19C	1666..2064	CDD:239124	105/479 (22%)
		DUF3517	2198..2566	CDD:463438
UBP12	NP_012338.1	UBP12	99..1111	CDD:227847	250/1303 (19%)