DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment faf and USP48

DIOPT Version :9

Sequence 1:	NP_524612.2	Gene:	faf / 43749	FlyBaseID:	FBgn0005632	Length:	2778	Species:	Drosophila melanogaster
Sequence 2:	NP_115612.4	Gene:	USP48 / 84196	HGNCID:	18533	Length:	1035	Species:	Homo sapiens

Alignment Length:	666	Identity:	151/666 - (22%)
Similarity:	240/666 - (36%)	Gaps:	229/666 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1657 PPVGARPTKGFCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGEDFSGDSDLTGGGL 1721
            |....|....|.||.|.|||||:|:.||..::...:|
Human    78 PNCERRKKNSFVGLTNLGATCYVNTFLQVWFLNLELR---------------------------- 114

  Fly  1722 GSALFSGPASALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGHSALQYYVPRGLWTHF 1786
             .||:..|::.      |...:.||:.:.:......|.:|:|.:||.|.:|..:|..|.|.   .
Human   115 -QALYLCPSTC------SDYMLGDGIQEEKDYEPQTICEHLQYLFALLQNSNRRYIDPSGF---V 169

  Fly  1787 KLLGEPVNLREQQDAVEF---FMSLLESLDEGLKALGQPQLMNAT---LGGSFSDQKICQECPHR 1845
            |.||  ::..:||||.||   ||||||   :.|.....|.:.|..   ..|.::...:|.:|...
Human   170 KALG--LDTGQQQDAQEFSKLFMSLLE---DTLSKQKNPDVRNIVQQQFCGEYAYVTVCNQCGRE 229

  Fly  1846 YSKEEPFSVFSVDIRNHSSLTESLEQYVKGELLEGADAYHCDKCDKKVVTVKRVCVKKLPPVLAI 1910
            ......|....::|:.|..||:.:.:::|.|.|||.:.|.|:.|..|....:::.:..||..|.:
Human   230 SKLLSKFYELELNIQGHKQLTDCISEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNL 294

  Fly  1911 QLKRFEYDYERVCAIKFNDYFEFPRILDMEPYTVSGLAKLEGEVVEVGDNCQTNVETTKYELTGI 1975
            ||.||.:|.:.....|.|.|..|..|||||||    :....|..|              |||:.:
Human   295 QLMRFVFDRQTGHKKKLNTYIGFSEILDMEPY----VEHKGGSYV--------------YELSAV 341

  Fly  1976 VVHSG-QASGGHYFSYILSKNPANGKCQWYKFDD-------GEVTECKMHED-------EEMKAE 2025
            ::|.| .|..|||.:::  |:|.:|  :||||:|       |:..:..:.||       :..|.:
Human   342 LIHRGVSAYSGHYIAHV--KDPQSG--EWYKFNDEDIEKMEGKKLQLGIEEDLAEPSKSQTRKPK 402

  Fly  2026 CFGGEYMGETYDNNLKRMQYRRQKRWWNAYMLFYTRCDQ----TPVQYEPSVEQL---------- 2076
            |..|.:...                  |||||.|....|    |.||....:::|
Human   403 CGKGTHCSR------------------NAYMLVYRLQTQEKPNTTVQVPAFLQELVDRDNSKFEE 449

  Fly  2077 ---SLAESRNMVLPLPKPIERSVRHQNIRFLHSRSIFSVEFFNFIKKLVSCNLLSARSNKITPAA 2138
               .:||.|...:...|     .:|:.::.|:.|.....|.:.|:.
Human   450 WCIEMAEMRKQSVDKGK-----AKHEEVKELYQRLPAGAEPYEFVS------------------- 490

  Fly  2139 EELSLLGVQLASQFLFHTGFRTKKSLRGPVMEWYDALSHHIRSSALVRKW---------FANHAL 2194
                                          :||             ::||         ..|||.
Human   491 ------------------------------LEW-------------LQKWLDESTPTKPIDNHAC 512

  Fly  2195 LSPPSRLGEYILMAPSPDVRTVFVKLV-----VFFCHFAINDEPLTGYDGA------NLCEQVLI 2248
            |....:|        .||..::..::.     :|:          :.|.|.      .||::.::
Human   513 LCSHDKL--------HPDKISIMKRISEYAADIFY----------SRYGGGPRLTVKALCKECVV 559

  Fly  2249 S---VLRLLKSEAADY 2261
            .   :|||......||
Human   560 ERCRILRLKNQLNEDY 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	114/418 (27%)
faf	NP_524612.2	UCH	1668..2059	CDD:278850	112/411 (27%)
USP48	NP_115612.4	UCH	89..418	CDD:278850	112/411 (27%)
		Peptidase_C19L	90..419	CDD:239133	112/411 (27%)
		DUSP	484..554	CDD:283896	16/149 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	612..640
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..919
		USP48_C	929..1035	CDD:176390
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810