Protein Alignment faf and USP9X

DIOPT Version :9

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: XP_005272732.1
• Gene: USP9X / 8239
• HGNCID: 12632
• Length: 2575
• Species: Homo sapiens
• Alignment Length: 2668
• Identity: 1260/2668 - (47%)
• Similarity: 1699/2668 - (63%)
• Gaps: 259/2668 - (9%)

  Fly    27 TTTTTTSPAQSAGSGSGIGTGTGTVANSSLPGGGSGSLDGNQDQQPAT--DSQSSDDVAASLSAN 89
            |.||..||   .|.....|......:...|....:.|.|.:.:..|||  |.|...|
Human     2 TATTRGSP---VGGNDNQGQAPDGQSQPPLQQNQTSSPDSSNENSPATPPDEQGQGD-------- 55

  Fly    90 SVDSTITIVPP--EKLISSFPTTKLRSLTQKISNPRWVVPVLPEQELEVLLNAAIELTQAGVDHD 152
                    .||  |....:||.|.|..|...|:.|||||||||:.||||||.|||:|::.|:|..
Human    56 --------APPQLEDEEPAFPHTDLAKLDDMINRPRWVVPVLPKGELEVLLEAAIDLSKKGLDVK 112

  Fly   153 CEPCVEFYRNGLSTSFAKILTDEAVNSWKNNIHHCILVSCGKLLHLIAIHMQRDNPYLLDLLAIV 217
            .|.|..|:|:||:.||.||||||||:.||..||.||:.:..:|:.|....:.:|...||:|||:.
Human   113 SEACQRFFRDGLTISFTKILTDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDWFPLLELLAMA 177

  Fly   218 FDPENKFNTFNAGRQPECFAAPDYIWGQLDSNKMYARPPPEPKNARGWLVDLINRFGQLGGFDNL 282
            .:|..||:.:| |.:| |.:....:  ||..::::|| .|:|::.:||||||:|:||.|.||..|
Human   178 LNPHCKFHIYN-GTRP-CESVSSSV--QLPEDELFAR-SPDPRSPKGWLVDLLNKFGTLNGFQIL 237

  Fly   283 LERFNIGLELLKRNQNKCTGKNISVEGRVENGAQDNRLTLALIHSLLRPFGQCYELLMPATIAKY 347
            .:||..|                            :.|.:.:|.:|::|||||||.|...|:.||
Human   238 HDRFING----------------------------SALNVQIIAALIKPFGQCYEFLTLHTVKKY 274

  Fly   348 FMPTWNVVLDLLDSFTDEELKREVKPEGRNDYINGIVKSARLLASRLTGQEELIRDLEMFRLKMI 412
            |:|...:|...|::.||||||:|.|.|.:||.::.|:||.:.||||:.||||.:::||:||||||
Human   275 FLPIIEMVPQFLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMI 339

  Fly   413 LRLLQVSSFNGKMNALNEINKVLSSVAYFSHRSQPLPHCMPEDEMDWLTADRMAQWIKSSDVLGV 477
            |||||:||||||||||||:|||:|||:|::||     |..||:| :||||:|||:||:.:::|.:
Human   340 LRLLQISSFNGKMNALNEVNKVISSVSYYTHR-----HGNPEEE-EWLTAERMAEWIQQNNILSI 398

  Fly   478 VLKDSLHQPQYVEKLEKIIRFLIKEQALTLDDLDAVWRAQAGKHEAIVKNVHDLLAKLAWDFTPE 542
            ||:|||||||||||||||:||:|||:||||.|||.:|.||||||||||||||||||||||||:||
Human   399 VLRDSLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPE 463

  Fly   543 QLDHLFEAFQASMTTANKRQRERLLELIRRLAEDDKNGVMAQKVLKLFWTLAHSQEVPPEVLDQA 607
            ||||||:.|:||.|.|:|:|||:|||||||||||||:||||.|||.|.|.||||.:||.:::|.|
Human   464 QLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPVDIMDLA 528

  Fly   608 LGAHVKILDYSCSQERDAQKTIWLDKCVDELKSGDGWVLPALRLIRDICCLY-----DTTTNHAQ 667
            |.||:|||||||||:||.||..|:|:.::||::.|.||:|||:.||:||.|:     :.:::...
Human   529 LSAHIKILDYSCSQDRDTQKIQWIDRFIEELRTNDKWVIPALKQIREICSLFGEAPQNLSSSRFS 593

  Fly   668 RTQTSTN---RQQVIERLQNDYSLVILVTNSLTAYMEKVRQMVTDSPGLDATRILIDGRFPHHVQ 729
            :||.|.:   |..:|.:||::::||.||..:|..|||.:|....|....|...:.:..|:.|..:
Human   594 QTQRSPHVFYRHDLINQLQHNHALVTLVAENLATYMESMRLYARDHEDYDPQTVRLGSRYSHVQE 658

  Fly   730 IAERLEFLKFLLKDGQLWLCADQAKQIWHCLAVNAVFPADREECFRWFGKLMGEEPDLDPGINKD 794
            :.|||.||:||||||||||||.||||||.|||.|||:..|||.||:|:.||||:||||||.||||
Human   659 VQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKD 723

  Fly   795 FFENNILQLDPHLLTESGIKCFERFFKAVNSKEDKLKAIHRGYMLDNEDLIGKDYLWRVITTGGE 859
            |||:|:|||||.||||:|:|||||||||||.:|.||.|..|.||:|:.:|||.||||||:....:
Human   724 FFESNVLQLDPSLLTENGMKCFERFFKAVNCREGKLVAKRRAYMMDDLELIGLDYLWRVVIQSND 788

  Fly   860 EIASKAIDLLKEVSTALGPRLQENIAEFHEMFIGECCSRLRTHYGNIVILGKTQLQEELDAPDQS 924
            :|||:|||||||:.|.||||||.|....||.||..|..||:..|..:.:|
Human   789 DIASRAIDLLKEIYTNLGPRLQVNQVVIHEDFIQSCFDRLKASYDTLCVL--------------- 838

  Fly   925 DNTNDESKDS-KMRFIEAEKMCRILKVLQEYVKECDRSFSGDRVHLPLSRVTRGKNTILYIRFQN 988
                |..||| .....||.:|.|:|.||:||:.|||..:..:|..||:||..|||:....:||.|
Human   839 ----DGDKDSVNCARQEAVRMVRVLTVLREYINECDSDYHEERTILPMSRAFRGKHLSFVVRFPN 899

  Fly   989 PGRSIDDMEIVTHSNETMAAFKRNLLKRIKGTSTANIKVDLFYANDEMIGVSDEINPLYQYTIRD 1053
            .||.:||:|:.:|:|:|:.:.:|.:|.||| .:.|:.|::|| ...|:|..:|:...:.|..::|
Human   900 QGRQVDDLEVWSHTNDTIGSVRRCILNRIK-ANVAHTKIELF-VGGELIDPADDRKLIGQLNLKD 962

  Fly  1054 KMNLTAKLTPVGTGLASSPDSSSDSSTGSP----------PRPCPDMQRVESESTLPGVIISQNY 1108
            |..:|||||.:.:.:.||||||||||||||          |.|       |.||.|||||:|.:.
Human   963 KSLITAKLTQISSNMPSSPDSSSDSSTGSPGNHGNHYSDGPNP-------EVESCLPGVIMSLHP 1020

  Fly  1109 QYTEFFLKLYQLGSDLEHGRLRDSAKVLLHLLPCDRQTIRQLKIMCKVPKAAVTVAVTGDKIAKD 1173
            :|..|..::..|||.|....|||.|:||:.|:|.|..||.:|:.:|.             ..||.
Human  1021 RYISFLWQVADLGSSLNMPPLRDGARVLMKLMPPDSTTIEKLRAICL-------------DHAKL 1072

  Fly  1174 EEEKLYPTEQAGIEDEEEHCTPEQMFLHPTPAQVLYNLSVLHGLLIPALDPLGESALLVQSAWMH 1238
            .|..|.|             :.:.:|..|:.:||||...|::.||:||..||.:.:...|..::.
Human  1073 GESSLSP-------------SLDSLFFGPSASQVLYLTEVVYALLMPAGAPLADDSSDFQFHFLK 1124

  Fly  1239 SGCAHFVLELLTKNNFLPSADMHTKRASFQCVLRLAKLFLYIVGSVLSRV----------GDEPM 1293
            ||....||.:||:|||||:|||.|:|.::...|::|||.|..:|....|.          |..||
Human  1125 SGGLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPGVEGVNPM 1189

  Fly  1294 ICDLDNGSRSQVDILKQNFSTMPS-SSQGTLRAISAKLAVILAREMLSASPEGDRCRTLFSSTLQ 1357
             ..::..:..|..:|:....::|: ||:..||.:|.:||       ...|.|..|
Human  1190 -TQINQVTHDQAVVLQSALQSIPNPSSECMLRNVSVRLA-------QQISDEASR---------- 1236

  Fly  1358 WSCPDISTIKAVVQLAWASSCGNLQAL----------------GNSSGDFEDEVIVPDGQDFSMC 1406
             ..|||..|:|:.::.|||.||:||.:                ||.          ||.:|..:|
Human  1237 -YMPDICVIRAIQKIIWASGCGSLQLVFSPNEEITKIYEKTNAGNE----------PDLEDEQVC 1290

  Fly  1407 KEALEVLTISFILNPSANEALTSDPNWPKFITSIVLKNPLRHVRQVASEQLFLASTYCAGDRRPF 1471
            .|||||:|:.|.|.|:|.:||:.:..|..||..::|....:.|||||.||.||..|.|....||.
Human  1291 CEALEVMTLCFALIPTALDALSKEKAWQTFIIDLLLHCHSKTVRQVAQEQFFLMCTRCCMGHRPL 1355

  Fly  1472 VYMVNLLVGALKTLVPQYESTCAEFFSVLCRTLSYGCIYNWPLQI--SEGLLGDEIKWLQRIREN 1534
            ::.:.||...|.:...:......::|::|...|:|.  ||..:.:  :|.||.:||.||:|||::
Human  1356 LFFITLLFTVLGSTARERAKHSGDYFTLLRHLLNYA--YNSNINVPNAEVLLNNEIDWLKRIRDD 1418

  Fly  1535 VHATGDTQVHEELLEGHLCLAKELMFFLGADSKAQLN------ELIHELIDDFLFTASREFLHLR 1593
            |..||:|.:.|.:|||||.:.|||:.|..::.|..:.      .||.||||||:|.||..:|...
Human  1419 VKRTGETGIEETILEGHLGVTKELLAFQTSEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYM 1483

  Fly  1594 RHGSLRQDTVPPPVCRSPHTIAAACDLLIALCQLCVPNMKLLTNTL-----IDFVCTDTDPLREW 1653
            |:|.|..:.. .|||.||.||.|..:||:||...||.|:|.:.::|     |....|..:.|.||
Human  1484 RNGELPAEQA-IPVCGSPPTINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEW 1547

  Fly  1654 DYLPPVGARPTKGFCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGEDFSGD---SD 1715
            :||||||.||.|||.||||||||||||||:|||||:|::|.|||...|..:...:|.|||   .:
Human  1548 EYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDN 1612

  Fly  1716 LTGGGLGSALFSGPASALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGHSALQYYVPR 1780
            .:.......:|..| ......|:.|.| ||     ||.|::.:|:|:|.||.||..|.|||||||
Human  1613 ESNVDPRDDVFGYP-QQFEDKPALSKT-ED-----RKEYNIGVLRHLQVIFGHLAASRLQYYVPR 1670

  Fly  1781 GLWTHFKLLGEPVNLREQQDAVEFFMSLLESLDEGLKALGQPQLMNATLGGSFSDQKICQECPHR 1845
            |.|..|:|.|||||||||.||:|||.||::||||.|||||.|.:::..|||||:||||||.||||
Human  1671 GFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHR 1735

  Fly  1846 YSKEEPFSVFSVDIRNHSSLTESLEQYVKGELLEGADAYHCDKCDKKVVTVKRVCVKKLPPVLAI 1910
            |..||.|:..:||||||.:|.:||||||||:|||||:||||:||:|||.||||:.:|||||||||
Human  1736 YECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAI 1800

  Fly  1911 QLKRFEYDYERVCAIKFNDYFEFPRILDMEPYTVSGLAKLEGEVVE-----VGDNCQTNVET--- 1967
            |||||:||:||.|||||||||||||.||||||||:|:|||||:.|.     :..:.|:..||
Human  1801 QLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDNVNPESQLIQQSEQSESETAGS 1865

  Fly  1968 TKYELTGIVVHSGQASGGHYFSYILSKNPANG-KCQWYKFDDGEVTECKMHEDEEMKAECFGGEY 2031
            |||.|.|::|||||||||||:|||:.:|..:| :.:|||||||:||||||.:|||||.:||||||
Human  1866 TKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGERNRWYKFDDGDVTECKMDDDEEMKNQCFGGEY 1930

  Fly  2032 MGETYDNNLKRMQYRRQKRWWNAYMLFYTRCDQTP-----VQYEPSVEQLSLAESRNMVLPLPKP 2091
            |||.:|:.:|||.|||||||||||:|||.|.|...     ::|   :.:|::....:.:: :|..
Human  1931 MGEVFDHMMKRMSYRRQKRWWNAYILFYERMDTIDQDDELIRY---ISELAITTRPHQII-MPSA 1991

  Fly  2092 IERSVRHQNIRFLHSRSIFSVEFFNFIKKLVSCNLLSAR----SNKITPAAEELSLLGVQLASQF 2152
            ||||||.||::|:|:|..:|:|:|.|:|||::||.:...    .:.:.|.|||::::.:|||::|
Human  1992 IERSVRKQNVQFMHNRMQYSMEYFQFMKKLLTCNGVYLNPPPGQDHLLPEAEEITMISIQLAARF 2056

  Fly  2153 LFHTGFRTKKSLRGPVMEWYDALSHHIRSSALVRKWFANHALLSPPSRLGEYILMAPSPDVRTVF 2217
            ||.|||.|||.:||...:|||||...:|.|..||.|||::.|.:..:|..||:|..||.:||..|
Human  2057 LFTTGFHTKKVVRGSASDWYDALCILLRHSKNVRFWFAHNVLFNVSNRFSEYLLECPSAEVRGAF 2121

  Fly  2218 VKLVVFFCHFAINDEPL-----------TGYDGANLCEQVLISVLRLLKSEAADYGKHLPHYFSL 2271
            .||:||..||::.|.|.           ..||..:|.:.:|.:||.||:.|.:::|:||..||:|
Human  2122 AKLIVFIAHFSLQDGPCPSPFASPGPSSQAYDNLSLSDHLLRAVLNLLRREVSEHGRHLQQYFNL 2186

  Fly  2272 FSMYVGLGTREKQQLLRLNVPLQFIQVALDDGPGPAIKYQYPEFSKLHQVVSHLIRCSDVSEKCQ 2336
            |.||..||..||.|||:|:||..|:.|:||:||||.|||||.|..||:.|||.||||.:||.:.|
Human  2187 FVMYANLGVAEKTQLLKLSVPATFMLVSLDEGPGPPIKYQYAELGKLYSVVSQLIRCCNVSSRMQ 2251

  Fly  2337 SSNQNARPLSNPFKDPNVAHEELTPLSTECMDLLFNRTGYIKKVIEDTNVGDEGLKLLQYCSWEN 2401
            ||.....||.|||.|||:: :.:.|:.....|:||.||.|:||:|||.:..:|.:|||::|.|||
Human  2252 SSINGNPPLPNPFGDPNLS-QPIMPIQQNVADILFVRTSYVKKIIEDCSNSEETVKLLRFCCWEN 2315

  Fly  2402 PHFSRAVLTELLWQCGFAYCHDMRHHTDLLLNILLIDDSWQHHRIHNALNGVAEEREGLLETIQR 2466
            |.||..||:|||||..::|.:::|.:.||||.||||:||||.|||||||.|:.::|:||.:||||
Human  2316 PQFSSTVLSELLWQVAYSYTYELRPYLDLLLQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQR 2380

  Fly  2467 AKTHYQKRAYQIIKCLTQLFHKSPIALQMLHTNSNITRHWSIAVEWLQGELDRQRGIG-CQYNSY 2530
            :|.||||||||.|||:..||...|:|.|:|..|.::.|.|:.|||||..||:|:...| .||...
Human  2381 SKNHYQKRAYQCIKCMVALFSNCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNPQYTYN 2445

  Fly  2531 SWSPPAQSNDNTNGYMLERSQSAKNTWSMAFELCPDEVSEKT-------DENNEPNLETNMDENK 2588
            :||||.|||:.:|||.||||.||:.|.:.|.||||:||.:.|       :|:.||:.:...||::
Human  2446 NWSPPVQSNETSNGYFLERSHSARMTLAKACELCPEEVKKATSVQQIEMEESKEPDDQDAPDEHE 2510

  Fly  2589 SEP 2591
            |.|
Human  2511 SPP 2513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	254/409 (62%)
		UCH	1668..2059	CDD:278850	249/402 (62%)
USP9X	XP_005272732.1	peptidase_C19C	1560..1963	CDD:239124	254/409 (62%)
		UCH	1562..1958	CDD:278850	249/402 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1238	1.000	Domainoid score	I10
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3418
Inparanoid	1	1.050	2268	1.000	Inparanoid score	I39
Isobase	1	0.950	-	0	Normalized mean entropy	S4546
OMA	1	1.010	-	-		QHG58606
OrthoDB	1	1.010	-	-		D22076at33208
OrthoFinder	1	1.000	-	-		FOG0002455
OrthoInspector	1	1.000	-	-		otm42054
orthoMCL	1	0.900	-	-		OOG6_102574
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4564
SonicParanoid	1	1.000	-	-		X1635
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820