Protein Alignment faf and USP7

DIOPT Version :10

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: NP_003461.2
• Gene: USP7 / 7874
• HGNCID: 12630
• Length: 1102
• Species: Homo sapiens
• Alignment Length: 934
• Identity: 193/934 - (20%)
• Similarity: 296/934 - (31%)
• Gaps: 342/934 - (36%)

  Fly  1642 FVCTDTDPLREWDYLPPVGARPTKGFCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTD 1706
            ||..|......||      ::...|:.||||.||||||||:||.|:....:|    :|.....|:
Human   194 FVQADAPHGVAWD------SKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLR----KAVYMMPTE 248

  Fly  1707 GEDFSGDSDLTGGGLGSALFSGPASALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGH 1771
            |:|.|                      .|:|.:                      :|.:|..|.|
Human   249 GDDSS----------------------KSVPLA----------------------LQRVFYELQH 269

  Fly  1772 SALQYYVPRGLWTHFKLLG-EPVNLREQQDAVEFFMSLLESLDEGLKALGQPQLMNATLGGSFSD 1835
            |.    .|.|.....|..| |.::...|.|..|....||::::..:|.    ..:..|:...|..
Human   270 SD----KPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKG----TCVEGTIPKLFRG 326

  Fly  1836 QKI----CQECPHRYSKEEPFSVFSVDIRNHSSLTESLEQYVKGELLEGADAYHCDKCDKKVVTV 1896
            :.:    |:|..:|..:.|.:....:.|:...::.||...||..|.|:|.:.|...:...:...
Human   327 KMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAE- 390

  Fly  1897 KRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDYFEFPRILDMEPYTVSGLAKLEGEVVEVGDNC 1961
            |.|....|||||.:||.||.||.:....||.||.||||..|.::.:    |.|.:.:
Human   391 KGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEF----LQKTDPK-------- 443

  Fly  1962 QTNVETTKYELTGIVVHSGQASGGHYFSYILSKNPANGKCQWYKFDDGEVTECKMHEDEEMKAEC 2026
                :...|.|..::||||...||||..|:   || .|..:|.||||..|:.|...|..|..
Human   444 ----DPANYILHAVLVHSGDNHGGHYVVYL---NP-KGDGKWCKFDDDVVSRCTKEEAIEHN--- 497

  Fly  2027 FGGEYMGETYDNNLKRMQYRRQKRWWNAYMLFYTRCDQTPVQYEPSVEQLSLAESRNMVLPLPKP 2091
            :||      :|::|.      .:...|||||.|.|             :..|:|....|
Human   498 YGG------HDDDLS------VRHCTNAYMLVYIR-------------ESKLSEVLQAV------ 531

  Fly  2092 IERSVRHQNIRFLHSRSIFSVEFFNFIKKLVSCNLLSARSNKITPAAEELSLLGVQLASQFLFHT 2156
            .:..:..|                 .:::|.....:.|:..|....|.....:.:....||..|.
Human   532 TDHDIPQQ-----------------LVERLQEEKRIEAQKRKERQEAHLYMQVQIVAEDQFCGHQ 579

  Fly  2157 GFRTKKSLRGPVMEWYDALSHHIRSSALVRKWFANHALLSPPSRLGEYILMAPSPDVRTVFVKLV 2221
            |
Human   580 G---------------------------------------------------------------- 580

  Fly  2222 VFFCHFAINDEPLTGYDGANLCEQVLISVLRLLKSEAADYGKHLPHYFSLFSMYVGLGTREKQQL 2286
                    ||.    ||.    |:|..:|.::||:.:      |..:....|..:|.    .|..
Human   581 --------NDM----YDE----EKVKYTVFKVLKNSS------LAEFVQSLSQTMGF----PQDQ 619

  Fly  2287 LRLNVPLQF-------------------IQVALDDGPGP-------------AIKYQYPEFSKLH 2319
            :|| .|:|.                   ..:.|.|...|             |.....|:|.|.|
Human   620 IRL-WPMQARSNGTKRPAMLDNEADGNKTMIELSDNENPWTIFLETVDPELAASGATLPKFDKDH 683

  Fly  2320 QVVSHLIRCSDVSEKCQSSNQNARPLSNPFKDPNVAHEELTPLSTECMDLL---FNRTGYIKKV- 2380
            .|:..|          :..:...|.|       |......||:|.:..|||   .:|.|:|:..
Human   684 DVMLFL----------KMYDPKTRSL-------NYCGHIYTPISCKIRDLLPVMCDRAGFIQDTS 731

  Fly  2381 --------------IEDTNVG---------DEGLKLLQYCSWENPHFSRAVLTELLWQCGFAYCH 2422
                          |:|.:|.         |..:.:.|....||.:.......|        |..
Human   732 LILYEEVKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSELPTAKE--------YFR 788

  Fly  2423 DMRHHTDLLLNILLIDDSWQHHRIHNALNGVAEEREGLLETIQRAKTHYQKRAYQIIKCLTQLFH 2487
            |:.|..|::.....|.:.                 .|.:.|:.....:     :|:.|.:.|..:
Human   789 DLYHRVDVIFCDKTIPND-----------------PGFVVTLSNRMNY-----FQVAKTVAQRLN 831

  Fly  2488 KSPIALQMLHTN------SNITRH 2505
            ..|:.||...:.      .|..||
Human   832 TDPMLLQFFKSQGYRDGPGNPLRH 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	Ubl1_cv_Nsp3_N-like	<994..1060	CDD:475130
		peptidase_C19C	1666..2064	CDD:239124	113/402 (28%)
		DUF3517	2198..2566	CDD:463438	63/373 (17%)
USP7	NP_003461.2	Interaction with TSPYL5. /evidence=ECO:0000269|PubMed:21170034	1..208		5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38
		Interaction with p53/TP53, MDM2 and EBNA1. /evidence=ECO:0000269|PubMed:14506283	53..208		5/19 (26%)
		Peptidase_C19	55..1100	CDD:470612	193/934 (21%)
		Necessary for nuclear localization	70..205		3/10 (30%)
		Interaction with ICP0/VMW110. /evidence=ECO:0000269|PubMed:16160161	622..801		37/204 (18%)